DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and Raf

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001096867.3	Gene:	Raf / 31221	FlyBaseID:	FBgn0003079	Length:	739	Species:	Drosophila melanogaster

Alignment Length:	312	Identity:	89/312 - (28%)
Similarity:	144/312 - (46%)	Gaps:	40/312 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PKDFVTDEDPLQLNVSSAIGDIQPHEIEYN----ELDIKEVIGSGGFCKVHRGYYDGEEVAIKIA 158
            |:....||.    |.:..:.|.:..|..:|    |:.|...||||.|..|:|.::.| .||:|..
  Fly   398 PRARSADES----NKNLLLRDAKSSEENWNILAEEILIGPRIGSGSFGTVYRAHWHG-PVAVKTL 457

  Fly   159 H--QTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNR---ILAG 218
            :  ......:|..::.|....|    .:|.||....|......|.:|.::..|.||.:   :...
  Fly   458 NVKTPSPAQLQAFKNEVAMLKK----TRHCNILLFMGCVSKPSLAIVTQWCEGSSLYKHVHVSET 518

  Fly   219 KIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLA-- 281
            |...:.|::...|:|:||:|||.:   :||||||||:|:.::|.:        ::||.|||||
  Fly   519 KFKLNTLIDIGRQVAQGMDYLHAK---NIIHRDLKSNNIFLHEDL--------SVKIGDFGLATA 572

  Fly   282 --REMYNTQRMSAAGTYAWMPPEVI---SVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVA 341
              |.....|.....|:..||.||||   .::.||..|||:::|::::||:....||.........
  Fly   573 KTRWSGEKQANQPTGSILWMAPEVIRMQELNPYSFQSDVYAFGIVMYELLAECLPYGHISNKDQI 637

  Fly   342 YGVAVNTLTLP----IPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESI 389
            ..:....|..|    :....|:....|.:.|.:..|..||.|:.:|..||::
  Fly   638 LFMVGRGLLRPDMSQVRSDAPQALKRLAEDCIKYTPKDRPLFRPLLNMLENM 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	1/5 (20%)
		TyrKc	129..386	CDD:197581	79/272 (29%)
		STKc_MLK	134..389	CDD:270963	80/270 (30%)
Raf	NP_001096867.3	RBD_RAF	142..212	CDD:340514
		C1_Raf	221..269	CDD:410361
		STKc_Raf	435..687	CDD:270964	78/267 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445242
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940