DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and Map3k11

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001013168.1	Gene:	Map3k11 / 309168	RGDID:	1359261	Length:	850	Species:	Rattus norvegicus

Alignment Length:	675	Identity:	292/675 - (43%)
Similarity:	384/675 - (56%)	Gaps:	117/675 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    47 LWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQLN 111
            :||||:||:..|:|||.||:|:.|.|||.|:.:|||.|||.|::|.:||:||.::|
  Rat    46 VWTALFDYEPNGQDELALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYV--------- 101

  Fly   112 VSSAIGDIQPHEI-EYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQ 175
              |..|...|.|: .:.||.::||||.|||.||:||.:.||.||:|.|.|..::|:....::|.|
  Rat   102 --SRGGGPPPCEVASFQELRLEEVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQ 164

  Fly   176 EAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAG-KIPPDVLVNWAIQIARGMNY 238
            ||:||..|.|.||.||:.||| ...||||||||.||.|:|.||| ::||.||||||:||||||:|
  Rat   165 EARLFAMLAHPNIIALKAVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHY 229

  Fly   239 LHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEV 303
            ||.||.:.:|||||||:|:|:.:.|||:.::.|||||||||||||.:.|.:||||||||||.|||
  Rat   230 LHCEALVPVIHRDLKSNNILLLQPIEGDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEV 294

  Fly   304 ISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSC 368
            |..||:||.|||||:|||||||:|||.||:|.|.|:||||||||.||||||.||||.:..||..|
  Rat   295 IKASTFSKGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADC 359

  Fly   369 WQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEE 433
            |..|||:||.|..||:|||::........|::|||.|||.|::||.|:..:||.|||       |
  Rat   360 WAQDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEK-------E 417

  Fly   434 LRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIEREL-VMLQPVPSKRKH---KKG--KKN 492
            |.::||:|.|...|||.:|..|:.||..|.:.|..:.|||| ::||.|..:|.|   ::|  |::
  Rat   418 LLSREEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKRS 482

  Fly   493 K------PLQISLPTGFRHTITAVRDKAEQPG--------------SPSFSGLRIVALTDGHKGK 537
            |      ..:||:|..|:|.||.    ...||              ||:|...|.:.|.....|:
  Rat   483 KLRARDGGERISMPLDFKHRITV----QASPGLDRRRNVFEVGAGDSPTFPRFRAIQLEPAESGQ 543

  Fly   538 T----------------------WGPST------MHQRERSLL--------------------PS 554
            |                      ||||:      .:.|.||.:                    |.
  Rat   544 TWGRQSPRRLDDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPLGSPSTPP 608

  Fly   555 QLSGG------QPEWPAQTS-THSSFSKSAPNLDKKQQQQNQQQVAS------LTPPPGLGILGG 606
            .|:|.      :||.|.::. |....|...|.|.::...:....:||      |.||.||....|
  Rat   609 ALNGNPPRPSPEPEEPRRSGPTERGNSSGTPKLIQRALLRGTALLASLGLGRDLQPPGGLSRERG 673

  Fly   607 SGGAGGTPA-----TPLLYPGIPII 626
            .......||     .|...|..|:|
  Rat   674 ESPTAPPPAQMASPCPPDLPSTPLI 698

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	31/56 (55%)
		TyrKc	129..386	CDD:197581	163/258 (63%)
		STKc_MLK	134..389	CDD:270963	164/256 (64%)
Map3k11	NP_001013168.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	18..37
		SH3_MLK1-3	46..103	CDD:212992	31/67 (46%)
		STKc_MLK3	114..380	CDD:271049	167/265 (63%)
		STYKc	118..377	CDD:214568	163/258 (63%)
		Leucine-zipper 1	404..425		11/27 (41%)
		Leucine-zipper 2	439..460		9/20 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..850		34/163 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	342	1.000	Domainoid score	I1037
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		otm46347
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.770