DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and Lrrk1

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001178553.1	Gene:	Lrrk1 / 308703	RGDID:	1308000	Length:	2013	Species:	Rattus norvegicus

Alignment Length:	394	Identity:	109/394 - (27%)
Similarity:	178/394 - (45%)	Gaps:	84/394 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PKDFVTDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGF-CKVHRGYYDGEEVAIK----- 156
            |:.|:|| .|.:|.:.::       ::|:.|.: ..::|.||. ..:::..|.|:.||:|
  Rat  1220 PELFMTD-FPARLFLENS-------KLEHTEGE-NSILGQGGSGTVIYQAQYQGQPVAVKRFHIK 1275

  Fly   157 -------------IAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYAR 208
                         :.|....|.|:...| ..|||.:..||:|..|.:|.|:.:: .||..:|.|.
  Rat  1276 KFKNSANAPADTMLRHLRAMDAMKNFSD-FRQEASMLHALQHPCIVSLIGISIH-PLCFALELAP 1338

  Fly   209 GGSLNRILAGKIPPDVLV--------NWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEG 265
            .||||.:|:........:        ..|.|||.|:.|||.:   :||..||||.|:|::.
  Rat  1339 LGSLNTVLSENAKDSSFMPLGHMLTQKIAYQIASGLAYLHKK---NIIFCDLKSDNILVWS---- 1396

  Fly   266 NHLQQKTL---KITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELIT 327
              |..|.|   |::|:|::|:.::...:...||..:..||:.....|.:..|::|||::|:||::
  Rat  1397 --LSVKELINIKLSDYGISRQSFHEGALGVEGTPGYQAPEIRPRIVYDEKVDMFSYGMVLYELLS 1459

  Fly   328 GETPYKGFDPLSVAYGVAVNTLTLPIPKTC--PE-----TWGALMKSCWQTDPHKRPGFKEILKQ 385
            |:.|..|...|.:     |..|:..|....  ||     ...|||..||.|.|.|||....::.|
  Rat  1460 GQRPALGHHQLQI-----VKKLSKGIRPVLGQPEEVQFYRLQALMMECWDTKPEKRPLALSVVSQ 1519

  Fly   386 LES---------IACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKEEQL 441
            ::.         :.|.|     |.||...|.   :|...|..|.:|:.:.:..:     |.|:.|
  Rat  1520 MKDPTFATFMYMLPCGK-----QSSFFSSQS---QEYTVVFWDGKEESRNYTVV-----NTEKGL 1571

  Fly   442 LRVQ 445
            |.||
  Rat  1572 LEVQ 1575

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	2/5 (40%)
		TyrKc	129..386	CDD:197581	84/293 (29%)
		STKc_MLK	134..389	CDD:270963	85/300 (28%)
Lrrk1	NP_001178553.1	ANK	91..214	CDD:238125
		ANK repeat	91..119	CDD:293786
		Ank_2	126..221	CDD:289560
		ANK repeat	156..186	CDD:293786
		ANK repeat	188..218	CDD:293786
		LRR_RI	<273..464	CDD:238064
		LRR	<279..513	CDD:227223
		leucine-rich repeat	281..303	CDD:275380
		leucine-rich repeat	304..330	CDD:275380
		leucine-rich repeat	331..381	CDD:275380
		leucine-rich repeat	382..405	CDD:275380
		leucine-rich repeat	406..451	CDD:275380
		leucine-rich repeat	452..474	CDD:275380
		leucine-rich repeat	475..498	CDD:275380
		leucine-rich repeat	499..549	CDD:275380
		leucine-rich repeat	550..572	CDD:275380
		Gem1	635..>781	CDD:224025
		P-loop_NTPase	639..821	CDD:304359
		COR	844..1036	CDD:292713
		S_TKc	1247..1511	CDD:214567	82/279 (29%)
		STKc_LRRK1	1248..1523	CDD:270969	85/290 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810