DRSC/TRiP Functional Genomics Resources

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Protein Alignment slpr and Map3k10

DIOPT Version :10

Sequence 1:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001382027.1 Gene:Map3k10 / 308463 RGDID:1308381 Length:940 Species:Rattus norvegicus


Alignment Length:645 Identity:308/645 - (47%)
Similarity:382/645 - (59%) Gaps:93/645 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    45 GSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKI-GDKVGVFPKDFVTDEDPL 108
            |.:|||::||:|.|::|||||||:.|.|||.|..||||.|||||:: ..:|||||.::|....| 
  Rat    18 GPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPAAP- 81

  Fly   109 QLNVSSAIGDIQ-PHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDN 172
                 :|..|:| |.||.::||.::|:||.|||.||:|..:.|||||:|.|....|.|.....:.
  Rat    82 -----AAPTDLQLPQEIPFHELQLEEIIGVGGFGKVYRALWRGEEVAVKAARLDPERDPAVTAEQ 141

  Fly   173 VLQEAKLFWALKHENIAALRGVCLN-TKLCLVMEYARGGSLNRILAG-KIPPDVLVNWAIQIARG 235
            |.|||:||.||:|.||.||||.||: ..|||||||||||:|:|:||| ::||.||||||:|:|||
  Rat   142 VRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARG 206

  Fly   236 MNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMP 300
            ||||||:||:.||||||||.|:||.||||.::|....|||||||||||.:.|.:||||||||||.
  Rat   207 MNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMA 271

  Fly   301 PEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALM 365
            ||||.:|.:||.|||||:|||||||:|||.||:..|.|:||||||:|.||||||.||||.:..|:
  Rat   272 PEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLL 336

  Fly   366 KSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTI 430
            :.||..|||.||.|..||||||.|..|.....|.||||.:||.|:.||..:..|||.|||     
  Rat   337 EECWDPDPHGRPDFGSILKQLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRTKEK----- 396

  Fly   431 EEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVML-----QPVPSKRKHKKGK 490
              |||::||:|||...|||.:...|:.|||.|.|||..::||||.:|     |..|..||.|...
  Rat   397 --ELRSREEELLRAAQEQRFQEEQLRRREQELAEREMDIVERELHLLMSQLSQEKPRVRKRKGNF 459

  Fly   491 KNKPL--------QISLPTGFRHTITAV----------RDKAEQPGSPS-FSGLRIVALT----- 531
            |...|        .||||:||.|.||..          .|.|..|.||| ...||.:.||     
  Rat   460 KRSRLLKLREGSSHISLPSGFEHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPVDCG 524

  Fly   532 ---------------------DGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSK 575
                                 ...||:|||||:..|:||       :||:....|.......:|.
  Rat   525 SSGGSGTWSRSGPPKKEELVGGKKKGRTWGPSSTLQKER-------AGGEERLKALGEGSKQWSS 582

  Fly   576 SAPNLDKKQQQQNQQQVASLTP-PPGLGIL------GGSGGAGGTPATPLLYPG---IPI 625
            |||||.|..:.         || .||...|      ..:......|.:|...|.   :|:
  Rat   583 SAPNLGKSPKH---------TPMAPGFASLNEMEEFAEADEGNNVPPSPYSTPSYLKVPL 633

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809 34/57 (60%)
STKc_MLK 134..389 CDD:270963 166/256 (65%)
Map3k10NP_001382027.1 SH3_MLK1-3 20..76 CDD:212992 33/55 (60%)
Protein Kinases, catalytic domain 103..360 CDD:473864 166/256 (65%)
Leucine-zipper 1 384..405 12/27 (44%)
Leucine-zipper 2 419..440 12/20 (60%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 490..599 32/124 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..658
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 687..732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 748..916
Blue background indicates that the domain is not in the aligned region.

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