Protein Alignment slpr and Ripk1

DIOPT Version :9

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_001100820.1
• Gene: Ripk1 / 306886
• RGDID: 1310158
• Length: 658
• Species: Rattus norvegicus
• Alignment Length: 670
• Identity: 157/670 - (23%)
• Similarity: 253/670 - (37%)
• Gaps: 198/670 - (29%)

  Fly   111 NVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKV----HRGYYDGEEVAIKIAHQTGEDDMQRMRD 171
            |:..|..|:    :|..:||      ||||.||    ||.:  |..:..|:  .||.:..: ..:
  Rat     9 NIKMASDDL----LERKDLD------SGGFGKVSLCFHRTH--GFVILKKV--YTGPNRAE-YNE 58

  Fly   172 NVLQEAKLFWALKHENIAALRGVCLNT-KLCLVMEYARGGSLNRILAGK--IPPDVLVNWAIQIA 233
            .:|:|.|:...|:|:.:..|.|:.:.. ...|||||...|:|..:|..|  :|..|.....::|.
  Rat    59 ALLEEGKMMHRLRHDRVVKLLGIIIEEGNYSLVMEYMEQGNLMHVLKTKESVPLSVKGRIIVEII 123

  Fly   234 RGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLA---------REMYNTQR 289
            .||:|||:|   .:||:|||..|:|:.....        :||.|.|:|         :|.:|.||
  Rat   124 EGMHYLHDE---GVIHKDLKPENILVDRDFH--------IKIADLGVASFKTWSKLTKEEHNKQR 177

  Fly   290 MSAA------GTYAWMPPE-VISVSTY-SKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAV 346
            .:::      ||..:|.|| :..::|. ::.|||:|:.::||.:...:.||:.. ..:..:.|.:
  Rat   178 EASSVTKKNGGTLYYMAPEHLTDINTKPTEKSDVYSFAIVLWAIFANKEPYENV-ICTEQFLVCI 241

  Fly   347 NTLTLP----IPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQES------ 401
            |:...|    |.:.||....:||:.||||:|..||.|..|.|:.:....|:|....:|.
  Rat   242 NSGNRPNVEDILEFCPREIISLMERCWQTNPEDRPTFFGIEKEFKPFYLSQFEEYVEEDVASLKK 306

  Fly   402 ------------FHYMQEC-------WRKEIAGVLHDLR------EKEKRFQTIEEELRNKEEQL 441
                        |....:|       ...|..|.||..:      .:|..|.:..|..:.:.|:.
  Rat   307 EYPSQSPVLKRMFSLQHDCVPLPPSRSNSEQPGSLHSSQGLPMGPVEESWFSSSPEYPQEENERS 371

  Fly   442 L--RVQNE----------QREKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKP 494
            :  ::|.|          :::..:..::.|...||.||    :..|...|...:|.|:..|
  Rat   372 VQAKLQEEASYHAFGIFAEKQTKSQPRLNEAYNREEER----KRRVSHDPFAQQRVHENVK---- 428

  Fly   495 LQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGG 559
                                                :.|.||..:..:|.|..    ...||||.
  Rat   429 ------------------------------------SAGAKGLPYPSTTSHGN----AAHQLSGP 453

  Fly   560 Q-----PEWPAQTSTHSSFSKS------APNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGT 613
            .     |.|......|..|..:      .|::       :|...|..||.|...:      .|..
  Rat   454 ASQIKVPLWNNGVYNHHGFGATGTGVWYGPSV-------SQSYNAYKTPVPETNL------PGSI 505

  Fly   614 PATP---LLYPGIPIILTRPNNN--NIGN----------------CKAITTT----ITTTTTTTT 653
            |..|   |..|...|..|..|::  .|||                ||..:|:    :...||:.|
  Rat   506 PTMPYISLAPPDDSIRCTIYNSSRVQIGNYNYMDLGPSSQPPTNTCKVESTSRHQAVFANTTSLT 570

  Fly   654 NNNNNNNNSISANNNNQLNN 673
               :.:.|.|..|...|..|
  Rat   571 ---DKHLNPIRENMGKQWKN 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	87/284 (31%)
		STKc_MLK	134..389	CDD:270963	85/282 (30%)
Ripk1	NP_001100820.1	PKc_like	23..290	CDD:419665	87/289 (30%)
		Death_RIP1	570..655	CDD:260048	6/21 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810