DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and Map3k13

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001014000.2	Gene:	Map3k13 / 303823	RGDID:	1561227	Length:	958	Species:	Rattus norvegicus

Alignment Length:	1058	Identity:	276/1058 - (26%)
Similarity:	411/1058 - (38%)	Gaps:	267/1058 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 LPISEEQQLQQQQQQQQLEQLHHPQIPE------IPI----------PDLEQVETQVGDGS---L 47
            ||::|.:....:.:...:.....|:.||      :.|          |....|.|.|.:.|   .
  Rat    16 LPLTENKISGGRNELAAMGNHPSPKFPEDSQERVVAIQSELTEITGSPVSTTVLTSVSEDSRSQF 80

  Fly    48 WTALYDYDAQGEDELTLRRG--------------EIVVVLSTDSEVSGDVGWWTGKIG---DKVG 95
            ..::.....|.|.|:|:..|              :|.:..|...  ||..|:..|..|   ....
  Rat    81 ENSVLQLREQDESEVTVSPGNSNTVDGENTNGPEDIKIQFSRSG--SGSGGFLEGLFGCLRPVWN 143

  Fly    96 VFPKDFVTDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQ 160
            :..|.:.||....|.:.         .|:.:.|:...:.:|||....|..|.:..||||||...:
  Rat   144 IIGKAYSTDYKLQQQDT---------WEVPFEEISELQWLGSGAQGAVFLGKFRAEEVAIKKVRE 199

  Fly   161 TGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTK-LCLVMEYARGGSLNRIL-AG-KIPP 222
            ..|.|::.:|           .|||.||.|.:|||.... .|::|||...|.|..:| || ||.|
  Rat   200 QNETDIKHLR-----------KLKHPNIIAFKGVCTQAPCYCIIMEYCAHGQLYEVLRAGRKITP 253

  Fly   223 DVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYN- 286
            .:||:|:..||.||||||..   .||||||||.|||:      .|..  .:||:|||.::|:.:
  Rat   254 RLLVDWSTGIASGMNYLHLH---KIIHRDLKSPNVLV------THTD--AVKISDFGTSKELSDK 307

  Fly   287 TQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTL 351
            :.:||.|||.|||.||||.....|:..|:||:||:||||:|||.|||..|..::.:||..|:|.|
  Rat   308 STKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHL 372

  Fly   352 PIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGV 416
            |:|.|||:.:..|||..||:.|..||.|::.|..|: ||.:....||||::...|..||:|:
  Rat   373 PVPSTCPDGFKILMKQTWQSKPRNRPSFRQTLMHLD-IASADVLATPQETYFKSQAEWREEV--- 433

  Fly   417 LHDLREKEKRFQTIEEE---LRNKEEQLLRVQNEQREKANLLKIREQ------------------ 460
                   :|.|:.|:.|   :...:|:|:|.:.|:...|  |.|||.
  Rat   434 -------KKHFEKIKSEGTCIHRLDEELIRRRREELRHA--LDIREHYERKLERANNLYMELSAI 489

  Fly   461 --NLRERERVLIERELVMLQPVPS--------------------KRK---HKKGKKNKPLQISLP 500
              .|..||:.|::||..:.:..|.                    |||   ||.|.:.|...:...
  Rat   490 MLQLEMREKELLKREQAVEKKYPGTYKRHPVRPIIHPNAMEKLMKRKVVSHKAGVQTKRPDLLRS 554

  Fly   501 TGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERS---------LLPSQL 556
            .|...| .||...:...|||..|        .|.....:.....|:|..|         :|.:|
  Rat   555 EGIPST-EAVPTASPLSGSPKMS--------TGSSRSRYRSKPRHRRGNSRGSHSDFAAILKTQ- 609

  Fly   557 SGGQPEWPAQ-TSTHSSFSKSAPNLDKKQQQQN--QQQVASLTPPPGLGILGGSGGAGGTPATPL 618
                   ||| .|.|.::.:..........|.|  ||||....|......|...|....|.|..|
  Rat   610 -------PAQENSPHPTYLQHTQAQCPSAYQHNLPQQQVPPPLPQSRHPRLNAHGQDIATCANNL 667

  Fly   619 LYPGIPIILTRPNNNNI-----GNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTIN 678
            .|.|....|..|.:|:.     |:...:.:  |........|:..:.:.:......|........
  Rat   668 RYFGPAAALRSPLSNHAQRQMPGSSPDLIS--TAMAADCWRNSELDQDQVGPWGCCQAEPYDPCF 730

  Fly   679 SNNNNNQTNL---TSQPNTIIVLQNGRNNSNSSTTSQSP----AKIYHRARSQEY-----GLDH- 730
            .....:..:|   |::|       .||:...||:.:.:|    |:...|..:..:     |:.|
  Rat   731 QCRPEHSGSLDVPTTEP-------VGRSPDPSSSPAHNPLSGNAQGSERTEANGFNGCQSGISHQ 788

  Fly   731 ---PLAYQPP-PLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGR 791
               ||..|.| ||....|||||.:                              |.:.:.....|
  Rat   789 FTPPLLPQKPRPLQKSGDDSSEEE------------------------------GEVDSEVEFPR 823

  Fly   792 KK--HSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGD 854
            ::  |...||........|.:|::.:     .|:.||.||:...|       .|:.|...:.:..
  Rat   824 RQRPHRCISSYQSYSTFSSENFSVSD-----GEEGNTSDHSNSPD-------ESANRRQDRLAET 876

  Fly   855 LTMYNSSTP------------LTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEG---- 903
            |....|.||            |:.::|          ..:|..:.....:.|    .||.|
  Rat   877 LDDLLSQTPEAPIEISSHSDGLSDKEC----------AVRRVKTQMSLGKLC----AEERGYENP 927

  Fly   904 -EAEDEDAVAAEVDTADA 920
             :..|.|..::|.|.:||
  Rat   928 VQFADSDRDSSEGDCSDA 945

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	13/73 (18%)
		TyrKc	129..386	CDD:197581	113/260 (43%)
		STKc_MLK	134..389	CDD:270963	114/258 (44%)
Map3k13	NP_001014000.2	STYKc	168..402	CDD:214568	112/255 (44%)
Map3k13	NP_001014000.2	STKc_MAP3K12_13	174..410	CDD:270961	114/258 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010