DRSC/TRiP Functional Genomics Resources

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Protein Alignment slpr and Lrrk2

DIOPT Version :9

Sequence 1:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001178718.1 Gene:Lrrk2 / 300160 RGDID:1561168 Length:2526 Species:Rattus norvegicus


Alignment Length:572 Identity:134/572 - (23%)
Similarity:231/572 - (40%) Gaps:143/572 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    23 HHPQIPEIPIPDLEQVETQVGDGSL----WTALYDYDAQGE-------DELTLRRGEIVVVLSTD 76
            |...:.|...|.|.:::. .|:|..    | |||.:: .||       |||..:..|..::::.|
  Rat  1782 HIDSLMEEWFPGLLEIDI-CGEGETLLKKW-ALYSFN-DGEEHQKILLDELMKKAEEGDLLINPD 1843

  Fly    77 --------SEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQLNVSSAIGDIQPHEIEYNELDIKE 133
                    |:::.|:     .:.|    .|::.:.:.|                |:|:.|.. :.
  Rat  1844 QPRLTIPISQIAPDL-----ILAD----LPRNIMLNND----------------ELEFEEAP-EF 1882

  Fly   134 VIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNT 198
            ::|.|.|..|:|..|:|||||:||.::  ...::.:|    ||..:...|.|.::.:|....:..
  Rat  1883 LLGDGSFGSVYRAAYEGEEVAVKIFNK--HTSLRLLR----QELVVLCHLHHPSLISLLAAGIRP 1941

  Fly   199 KLCLVMEYARGGSLNRIL---AGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIY 260
            :: ||||.|..|||:|:|   ...:...:....|:.:|.|:.|||:   ..||:||||..|||::
  Rat  1942 RM-LVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHS---AMIIYRDLKPHNVLLF 2002

  Fly   261 EAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVST-YSKFSDVWSYGVLLWE 324
            .......:   ..||.|:|:|:........::.||..:..|||...:. |::.:||:|:|:||.:
  Rat  2003 TLYPNAAI---IAKIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLHD 2064

  Fly   325 L-ITGETPYKG------FDPLSV---------AYGVAVNTLTLPIPKTCPETWGALMKSCWQTDP 373
            : .||....:|      ||.|::         .||.|      |.|..     ..|:..|.:.:|
  Rat  2065 IWTTGNRIMEGLRFPNEFDELAIQGKLPDPVKEYGCA------PWPMV-----EKLITKCLKENP 2118

  Fly   374 HKRPGFK---EILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELR 435
            .:||...   :||...|.|...:....|::   ...||    ||..                .|.
  Rat  2119 QERPTSAQVFDILNSAELICLMRHIFIPKD---ITVEC----IAAT----------------NLN 2160

  Fly   436 NKEEQL-LRVQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQISL 499
            :|...| |...|.::.:.:||.:..:.....|  :.:..::.|..|     |...:|...:....
  Rat  2161 SKRATLWLGCGNTEKGQLSLLDLNTERYSYEE--VTDSRILCLALV-----HLAAEKESWVVCGT 2218

  Fly   500 PTGF-----------RHTITAVRDKAEQPGSPSF------SGLRIVALTDGH 534
            .:|.           |||:..:.|........||      |...:|...||:
  Rat  2219 QSGALLVINAEDETRRHTLDKMTDSVTCLYCNSFAKQSKQSHFLLVGTADGN 2270

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809 15/75 (20%)
TyrKc 129..386 CDD:197581 79/279 (28%)
STKc_MLK 134..389 CDD:270963 80/277 (29%)
Lrrk2NP_001178718.1 leucine-rich repeat 984..1011 CDD:275380
leucine-rich repeat 1012..1035 CDD:275380
leucine-rich repeat 1036..1058 CDD:275380
leucine-rich repeat 1059..1083 CDD:275380
leucine-rich repeat 1084..1107 CDD:275380
leucine-rich repeat 1108..1129 CDD:275380
leucine-rich repeat 1130..1173 CDD:275380
leucine-rich repeat 1174..1196 CDD:275380
leucine-rich repeat 1197..1220 CDD:275380
leucine-rich repeat 1221..1245 CDD:275380
Gem1 1332..1550 CDD:224025
RocCOR 1333..1506 CDD:206741
COR 1526..1739 CDD:292713
S_TKc 1883..2145 CDD:214567 81/285 (28%)
STKc_LRRK2 1883..2134 CDD:270970 79/274 (29%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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