Protein Alignment slpr and ABL2

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_009298.1
• Gene: ABL2 / 27
• HGNCID: 77
• Length: 1182
• Species: Homo sapiens
• Alignment Length: 1182
• Identity: 249/1182 - (21%)
• Similarity: 406/1182 - (34%)
• Gaps: 445/1182 - (37%)

  Fly    20 EQLHHPQIPEIPIPDLEQV------ETQVG----DGSLWTALYDYDAQGEDELTLRRGEIVVVLS 74
            |.||.|...::....|.:.      |..:|    |.:|:.||||:.|.|::.|::.:||.:.||.
Human    74 EALHRPYGCDVEPQALNEAIRWSSKENLLGATESDPNLFVALYDFVASGDNTLSITKGEKLRVLG 138

  Fly    75 TDSEVSGDVGWWT---GKIGDKVGVFPKDFVT--------------------------------- 103
            .:..     |.|:   .|.|.  |..|.:::|
Human   139 YNQN-----GEWSEVRSKNGQ--GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFL 196

  Fly   104 ----DEDPLQLNVS----------------------------SAIGDIQPH-------------- 122
                :..|.||::|                            |.:.::..|
Human   197 VRESESSPGQLSISLRYEGRVYHYRINTTADGKVYVTAESRFSTLAELVHHHSTVADGLVTTLHY 261

  Fly   123 --------------------EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQ 167
                                |:|..::.:|..:|.|.:.:|:.|.:  ::.::.:|.:|.::|..
Human   262 PAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW--KKYSLTVAVKTLKEDTM 324

  Fly   168 RMRDNVLQEAKLFWALKHENIAALRGVC-LNTKLCLVMEYARGGSL-------NRILAGKIPPDV 224
            .: :..|:||.:...:||.|:..|.||| |.....:|.||...|:|       ||   .::...|
Human   325 EV-EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNR---EEVTAVV 385

  Fly   225 LVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQR 289
            |:..|.||:..|.||..:   :.|||||.:.|.|:.|    ||:    :|:.||||:|.|.....
Human   386 LLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGE----NHV----VKVADFGLSRLMTGDTY 439

  Fly   290 MSAAGT---YAWMPPEVISVSTYSKFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLT 350
            .:.||.   ..|..||.::.:|:|..||||::||||||:.| |.:||.|.| ||..|.:......
Human   440 TAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKGYR 503

  Fly   351 LPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFH-------YMQEC 408
            :..|:.||.....||::||:..|..||.|.|..:..|::            ||       ..:|.
Human   504 MEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFETM------------FHDSSISEEVAEEL 556

  Fly   409 WR----KEIAGVLHDLREKEKRFQTIEEELRNKEE-----------------QLLR--------- 443
            .|    ..:...|..|.....:.:|:::::.|||.                 ..:|
Human   557 GRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSASSLAPGFIRGAQASSGSP 621

  Fly   444 -VQNEQREK--ANLLKIREQNLRERER-------VLIERELVMLQPVPSKRK----------HKK 488
             :..:||:|  ::||:..::....|:|       .:.:|.    .|.|.||.          |||
Human   622 ALPRKQRDKSPSSLLEDAKETCFTRDRKGGFFSSFMKKRN----APTPPKRSSSFREMENQPHKK 682

  Fly   489 ----GKKNKPLQISLPTGFRHTIT----------------AVRDKAEQPG---------SPSFSG 524
                |..:....:....||..|..                |.|:.....|         ...:||
Human   683 YELTGNFSSVASLQHADGFSFTPAQQEANLVPPKCYGGSFAQRNLCNDDGGGGGGSGTAGGGWSG 747

  Fly   525 L------RIVALTDG-HKGK-TWGPSTMHQRERSLLPSQLSGGQPEWP--AQT------------ 567
            :      |::..|.| ..|| |....|.....||...|.:|.|.||..  |.|
Human   748 ITGFFTPRLIKKTLGLRAGKPTASDDTSKPFPRSNSTSSMSSGLPEQDRMAMTLPRNCQRSKLQL 812

  Fly   568 -STHSSFSKSAPNLD-------KKQQQ----QNQQQVASLTP---------------------PP 599
             .|.|:.|:...|:|       ||.::    ..::..|.|.|                     ||
Human   813 ERTVSTSSQPEENVDRANDMLPKKSEESAAPSRERPKAKLLPRGATALPLRTPSGDLAITEKDPP 877

  Fly   600 GLGILG---------GSGGA----------GGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTI 645
            |:|:.|         .:|||          |..|..|......|::.|..|:.       :...|
Human   878 GVGVAGVAAAPKGKEKNGGARLGMAGVPEDGEQPGWPSPAKAAPVLPTTHNHK-------VPVLI 935

  Fly   646 TTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTT 710
            :.|...|.                  .::..|.:::..|:..|.|:           :...||..
Human   936 SPTLKHTP------------------ADVQLIGTDSQGNKFKLLSE-----------HQVTSSGD 971

  Fly   711 SQSPAKIYHRARSQEYGLDHPLAYQPPP--LYLVTDDSSETDTVASPTGCFHFLKSGNSS----- 768
            ...|.::            .|....|||  :.|:...|..:|....||.    |.:|.|:
Human   972 KDRPRRV------------KPKCAPPPPPVMRLLQHPSICSDPTEEPTA----LTAGQSTSETQE 1020

  Fly   769 ----AASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPP--ANGSN------------------ 809
                ||.|||.:   .|..|. |.:...:..|.:||..|.  |||:.
Human  1021 GGKKAALGAVPI---SGKAGR-PVMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISA 1081

  Fly   810 -----------SFALPNQLTLPSEDNNTYD--HAF-------------------YRDVIKKMSMA 842
                       :..|.:.||.|..::...|  |..                   :|:.:.|:.::
Human  1082 DKISKEALLECADLLSSALTEPVPNSQLVDTGHQLLDYCSGYVDCIPQTRNKFAFREAVSKLELS 1146

  Fly   843 SSE-RVNSKSSG 853
            ..| :|:|.::|
Human  1147 LQELQVSSAAAG 1158

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	19/96 (20%)
		STKc_MLK	134..389	CDD:270963	89/266 (33%)
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..47
		CAP	2..106		7/31 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	60..80		3/5 (60%)
		SH3_Abl	111..164	CDD:212784	18/59 (31%)
		SH2_ABL	169..262	CDD:198189	6/92 (7%)
		PTKc_Abl	281..543	CDD:270645	92/291 (32%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		8/23 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	611..641		6/29 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..674		5/23 (22%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		0/1 (0%)
		F-actin-binding. /evidence=ECO:0000250	694..930		48/235 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	763..794		10/30 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	807..851		7/43 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	964..1024		15/75 (20%)
		F-actin-binding. /evidence=ECO:0000250	1020..1182		27/143 (19%)
		FABD	1063..1182	CDD:197885	12/96 (13%)