DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and Map3k10

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_017177776.1	Gene:	Map3k10 / 269881	MGIID:	1346879	Length:	991	Species:	Mus musculus

Alignment Length:	689	Identity:	310/689 - (44%)
Similarity:	386/689 - (56%)	Gaps:	130/689 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 GSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKI-GDKVGVFPKDFVTDEDPL 108
            |.:|||::||:|.|::|||||||:.|.|||.|..||||.|||||:: ..:|||||.::|....|
Mouse    18 GPVWTAVFDYEAVGDEELTLRRGDRVQVLSQDCAVSGDEGWWTGQLPSGRVGVFPSNYVAPAAP- 81

  Fly   109 QLNVSSAIGDIQ-PHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDN 172
                 :|..|:| |.||.::||.::|:||.|||.||:|..:.|||||:|.|....|.|.....:.
Mouse    82 -----AAPSDLQLPQEIPFHELQLEEIIGVGGFGKVYRAVWRGEEVAVKAARLDPERDPAVTAEQ 141

  Fly   173 VLQEAKLFWALKHENIAALRGVCLN-TKLCLVMEYARGGSLNRILAG-KIPPDVLVNWAIQIARG 235
            |.|||:||.||:|.||.||||.||: ..|||||||||||:|:|:||| ::||.||||||:|:|||
Mouse   142 VRQEARLFGALQHPNIIALRGACLSPPNLCLVMEYARGGALSRVLAGRRVPPHVLVNWAVQVARG 206

  Fly   236 MNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMP 300
            ||||||:||:.||||||||.|:||.||||.::|....|||||||||||.:.|.:||||||||||.
Mouse   207 MNYLHNDAPVPIIHRDLKSINILILEAIENHNLADTVLKITDFGLAREWHKTTKMSAAGTYAWMA 271

  Fly   301 PEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALM 365
            ||||.:|.:||.|||||:|||||||:|||.||:..|.|:||||||:|.||||||.||||.:..|:
Mouse   272 PEVIRLSLFSKSSDVWSFGVLLWELLTGEVPYREIDALAVAYGVAMNKLTLPIPSTCPEPFARLL 336

  Fly   366 --------KSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLRE 422
                    :.||..|||.||.|..||||||.|..|.....|.||||.:||.|:.||..:..|||.
Mouse   337 EGEPGPCGEECWDPDPHGRPDFGSILKQLEVIEQSALFQMPLESFHSLQEDWKLEIQHMFDDLRT 401

  Fly   423 KEK----RFQTIE--------------------------------EELRNKEEQLLRVQNEQREK 451
            |||    |.:..|                                :|||::||:|||...|||.:
Mouse   402 KEKLVMSRLEGCELRADAHKTHLSWDPGPAPAAKPYLWACLPPSHQELRSREEELLRAAQEQRFQ 466

  Fly   452 ANLLKIREQNLRERERVLIERELVML-----QPVPSKRKHKKGKKNKPL--------QISLPTGF 503
            ...|:.|||.|.|||..::||||.:|     |..|..||.|...|...|        .||||:||
Mouse   467 EEQLRRREQELAEREMDIVERELHLLMSQLSQEKPRVRKRKGNFKRSRLLKLREGSSHISLPSGF 531

  Fly   504 RHTITAV----------RDKAEQPGSPS-FSGLRIVALT-------------------------- 531
            .|.||..          .|.|..|.||| ...||.:.||
Mouse   532 EHKITVQASPTLDKRKGSDGASPPASPSIIPRLRAIRLTPMDCGGSSGSGTWSRSGPPKKEELVG 596

  Fly   532 DGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLT 596
            ...||:|||||:..|:||       :||:....|.......:|.|||||.|..:.         |
Mouse   597 GKKKGRTWGPSSTLQKER-------AGGEERLKALGEGSKQWSSSAPNLGKSPKH---------T 645

  Fly   597 P-PPGLGIL------GGSGGAGGTPATPLLYPG---IPI 625
            | .||...|      ..:......|.:|...|.   :|:
Mouse   646 PMAPGFASLNEMEEFAEADEGNNVPPSPYSTPSYLKVPL 684

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	34/57 (60%)
		TyrKc	129..386	CDD:197581	165/266 (62%)
		STKc_MLK	134..389	CDD:270963	166/264 (63%)
Map3k10	XP_017177776.1	SH3_MLK1-3	20..76	CDD:212992	33/55 (60%)
Map3k10	XP_017177776.1	PKc_like	103..368	CDD:389743	166/264 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	340	1.000	Domainoid score	I1088
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		otm44249
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4635
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.940