DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment slpr and Map3k12

DIOPT Version :10

Sequence 1:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_033608.3 Gene:Map3k12 / 26404 MGIID:1346881 Length:888 Species:Mus musculus


Alignment Length:1022 Identity:249/1022 - (24%)
Similarity:376/1022 - (36%) Gaps:356/1022 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHEN 187
            |:.:.|:...:.:|||....|..|.:.|||||:|......|.|::.:|           .|||.|
Mouse   152 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLR-----------KLKHPN 205

  Fly   188 IAALRGVCLNTK-LCLVMEYARGGSLNRIL-AGK-IPPDVLVNWAIQIARGMNYLHNEAPMSIIH 249
            |...:|||.... .|::||:...|.|..:| ||: :.|.:||:|::.||.||||||..   .|||
Mouse   206 IITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLH---KIIH 267

  Fly   250 RDLKSSNVLI-YEAIEGNHLQQKTLKITDFGLAREMYN-TQRMSAAGTYAWMPPEVISVSTYSKF 312
            |||||.|:|| |:.:         :||:|||.::|:.: :.:||.|||.|||.||||.....|:.
Mouse   268 RDLKSPNMLITYDDV---------VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 323

  Fly   313 SDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRP 377
            .|:||:||:||||:|||.|||..|..::.:||..|:|.||:|.:||:.:..|::.||.:.|..||
Mouse   324 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRP 388

  Fly   378 GFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEEL--RNKEEQ 440
            .|::||..|: ||.:....||||::...|..||:|:......::.:......:||||  |.:||.
Mouse   389 SFRQILLHLD-IASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREEL 452

  Fly   441 L----LRVQNEQR-EKAN-----------LLKIREQNLRERERVLIERELVMLQPVPSK------ 483
            .    :|...|:: |:||           .|:::|:.|..||:.|..|...:|:..||:      
Mouse   453 RHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHPSRGLLHGN 517

  Fly   484 --RKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQ 546
              .|..| |:|.|.::| |...|..|.                                      
Mouse   518 TMEKLIK-KRNVPQKLS-PHSKRPDIL-------------------------------------- 542

  Fly   547 RERSLLP---SQLSG-GQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPP----PGLGI 603
            :..||||   :.||| |.|..|          |..|:..:.::.:.:.:.||....    |||..
Mouse   543 KTESLLPKLDAALSGVGLPGCP----------KGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRA 597

  Fly   604 L------GGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNS 662
            .      ||.|..||....|..:...|..|.                                  
Mouse   598 ALPPHEPGGLGSPGGLGVGPSAWDACPPALR---------------------------------- 628

  Fly   663 ISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVL--QNGRNNSNSSTTSQSPAKIYHRARSQE 725
             ..:::..|..:|             :|.|:.:...  ..||..:..:....||           
Mouse   629 -GLHHDLLLRKMS-------------SSSPDLLSAALGARGRGATGGARDPGSP----------- 668

  Fly   726 YGLDHPLAYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVG 790
                      |||         :.||..|            ..:|.|:......||:.|..|   
Mouse   669 ----------PPP---------QGDTPPS------------EGSAPGSTSPDSPGGAKGEPP--- 699

  Fly   791 RKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDL 855
                        ||........|..                                        
Mouse   700 ------------PPVGPGEGVGLLG---------------------------------------- 712

  Fly   856 TMYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQF--PRHCFF----TRQEEEGEAEDEDAVAAE 914
                     |.|:    ..|..||    |.:|||.  |....:    ||.::.|.:.:|:     
Mouse   713 ---------TGRE----GTAGRGG----NRAGSQHLTPAALLYRAAVTRSQKRGISSEEE----- 755

  Fly   915 VDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFA 979
                :.:.|.|.::|.||........|:|..||.|   |.|           ||:...:||    
Mouse   756 ----EGEVDSEVELPPSQRWPQGPNMRQSLSTFSS---ENP-----------SDVEEGTAS---- 798

  Fly   980 TYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQRQQT 1044
                 .||       .|.:|.:.||              ||    |.:|         .|:....
Mouse   799 -----EPS-------PSGTPEVGST--------------NT----DERP---------DERSDDM 824

  Fly  1045 KNQKKQRPKHITKSKSV-EAPVEGQHHEHDDHNDPQHQHHSAGSSKI 1090
            .:|..:.|..:..|:.| |........:|.|...|..:.....|:::
Mouse   825 CSQGSEIPLDLPTSEVVPEREASSLPMQHQDGQGPNPEDSDCDSTEL 871

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809
STKc_MLK 134..389 CDD:270963 108/259 (42%)
Map3k12NP_033608.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..104
STKc_MAP3K12_13 164..400 CDD:270961 108/259 (42%)
Leucine-zipper 1 423..444 2/20 (10%)
Leucine-zipper 2 476..497 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 557..612 14/64 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..888 69/398 (17%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.