DRSC/TRiP Functional Genomics Resources

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Protein Alignment slpr and Map3k12

DIOPT Version :9

Sequence 1:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_001157115.1 Gene:Map3k12 / 26404 MGIID:1346881 Length:888 Species:Mus musculus


Alignment Length:1022 Identity:249/1022 - (24%)
Similarity:376/1022 - (36%) Gaps:356/1022 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHEN 187
            |:.:.|:...:.:|||....|..|.:.|||||:|......|.|::.:|           .|||.|
Mouse   152 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLR-----------KLKHPN 205

  Fly   188 IAALRGVCLNTK-LCLVMEYARGGSLNRIL-AGK-IPPDVLVNWAIQIARGMNYLHNEAPMSIIH 249
            |...:|||.... .|::||:...|.|..:| ||: :.|.:||:|::.||.||||||..   .|||
Mouse   206 IITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLH---KIIH 267

  Fly   250 RDLKSSNVLI-YEAIEGNHLQQKTLKITDFGLAREMYN-TQRMSAAGTYAWMPPEVISVSTYSKF 312
            |||||.|:|| |:.:         :||:|||.::|:.: :.:||.|||.|||.||||.....|:.
Mouse   268 RDLKSPNMLITYDDV---------VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 323

  Fly   313 SDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRP 377
            .|:||:||:||||:|||.|||..|..::.:||..|:|.||:|.:||:.:..|::.||.:.|..||
Mouse   324 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRP 388

  Fly   378 GFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEEL--RNKEEQ 440
            .|::||..|: ||.:....||||::...|..||:|:......::.:......:||||  |.:||.
Mouse   389 SFRQILLHLD-IASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREEL 452

  Fly   441 L----LRVQNEQR-EKAN-----------LLKIREQNLRERERVLIERELVMLQPVPSK------ 483
            .    :|...|:: |:||           .|:::|:.|..||:.|..|...:|:..||:      
Mouse   453 RHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALERRCPGLLKSHPSRGLLHGN 517

  Fly   484 --RKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQ 546
              .|..| |:|.|.::| |...|..|.                                      
Mouse   518 TMEKLIK-KRNVPQKLS-PHSKRPDIL-------------------------------------- 542

  Fly   547 RERSLLP---SQLSG-GQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPP----PGLGI 603
            :..||||   :.||| |.|..|          |..|:..:.::.:.:.:.||....    |||..
Mouse   543 KTESLLPKLDAALSGVGLPGCP----------KGPPSPGRSRRGKTRHRKASAKGSCGDLPGLRA 597

  Fly   604 L------GGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNS 662
            .      ||.|..||....|..:...|..|.                                  
Mouse   598 ALPPHEPGGLGSPGGLGVGPSAWDACPPALR---------------------------------- 628

  Fly   663 ISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVL--QNGRNNSNSSTTSQSPAKIYHRARSQE 725
             ..:::..|..:|             :|.|:.:...  ..||..:..:....||           
Mouse   629 -GLHHDLLLRKMS-------------SSSPDLLSAALGARGRGATGGARDPGSP----------- 668

  Fly   726 YGLDHPLAYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVG 790
                      |||         :.||..|            ..:|.|:......||:.|..|   
Mouse   669 ----------PPP---------QGDTPPS------------EGSAPGSTSPDSPGGAKGEPP--- 699

  Fly   791 RKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDL 855
                        ||........|..                                        
Mouse   700 ------------PPVGPGEGVGLLG---------------------------------------- 712

  Fly   856 TMYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQF--PRHCFF----TRQEEEGEAEDEDAVAAE 914
                     |.|:    ..|..||    |.:|||.  |....:    ||.::.|.:.:|:     
Mouse   713 ---------TGRE----GTAGRGG----NRAGSQHLTPAALLYRAAVTRSQKRGISSEEE----- 755

  Fly   915 VDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFA 979
                :.:.|.|.::|.||........|:|..||.|   |.|           ||:...:||    
Mouse   756 ----EGEVDSEVELPPSQRWPQGPNMRQSLSTFSS---ENP-----------SDVEEGTAS---- 798

  Fly   980 TYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQRQQT 1044
                 .||       .|.:|.:.||              ||    |.:|         .|:....
Mouse   799 -----EPS-------PSGTPEVGST--------------NT----DERP---------DERSDDM 824

  Fly  1045 KNQKKQRPKHITKSKSV-EAPVEGQHHEHDDHNDPQHQHHSAGSSKI 1090
            .:|..:.|..:..|:.| |........:|.|...|..:.....|:::
Mouse   825 CSQGSEIPLDLPTSEVVPEREASSLPMQHQDGQGPNPEDSDCDSTEL 871

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809
TyrKc 129..386 CDD:197581 107/261 (41%)
STKc_MLK 134..389 CDD:270963 108/259 (42%)
Map3k12NP_001157115.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..104
STKc_MAP3K12_13 164..400 CDD:270961 108/259 (42%)
Leucine-zipper 1 423..444 2/20 (10%)
Leucine-zipper 2 476..497 5/20 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 557..612 14/64 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 654..888 69/398 (17%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR44329
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X88
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
33.010

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