DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and DSTYK

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_056190.1	Gene:	DSTYK / 25778	HGNCID:	29043	Length:	929	Species:	Homo sapiens

Alignment Length:	229	Identity:	62/229 - (27%)
Similarity:	98/229 - (42%)	Gaps:	48/229 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   184 KHENIAALRGVCLNTKLCLVMEYARGGS-----------LNRILAGKIPPDVLVNWAIQIA---- 233
            |||.:..|.|        .|::|..||.           |:|.|...:...:.:...:|||
Human   706 KHERLVDLHG--------SVIDYNYGGGSSIAVLLIMERLHRDLYTGLKAGLTLETRLQIALDVV 762

  Fly   234 RGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRM---SAAGT 295
            .|:.:||::   .::|||:|..|||:.        :|...||||.|..:    .:.|   |..||
Human   763 EGIRFLHSQ---GLVHRDIKLKNVLLD--------KQNRAKITDLGFCK----PEAMMSGSIVGT 812

  Fly   296 YAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPY-KGFDPLSVAYGVAVNTLTLPIPKTCP- 358
            ...|.||:.: ..|....||:::|:|.|.:.:|.... :.|:..:....:..|......|:..|
Human   813 PIHMAPELFT-GKYDNSVDVYAFGILFWYICSGSVKLPEAFERCASKDHLWNNVRRGARPERLPV 876

  Fly   359 ---ETWGALMKSCWQTDPHKRPGFKEILKQLESI 389
               |.| .||::||..||.|||....:...|:.|
Human   877 FDEECW-QLMEACWDGDPLKRPLLGIVQPMLQGI 909

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	60/224 (27%)
		STKc_MLK	134..389	CDD:270963	61/227 (27%)
DSTYK	NP_056190.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		PKc_Dusty	651..912	CDD:270877	62/229 (27%)
		S_TKc	653..897	CDD:214567	58/215 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900