DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and Map3k12

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_037187.1	Gene:	Map3k12 / 25579	RGDID:	3988	Length:	888	Species:	Rattus norvegicus

Alignment Length:	983	Identity:	242/983 - (24%)
Similarity:	367/983 - (37%)	Gaps:	297/983 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHEN 187
            |:.:.|:...:.:|||....|..|.:.|||||:|......|.|::.:|           .|||.|
  Rat   152 EVPFEEILDLQWVGSGAQGAVFLGRFHGEEVAVKKVRDLKETDIKHLR-----------KLKHPN 205

  Fly   188 IAALRGVCLNTK-LCLVMEYARGGSLNRIL-AGK-IPPDVLVNWAIQIARGMNYLHNEAPMSIIH 249
            |...:|||.... .|::||:...|.|..:| ||: :.|.:||:|::.||.||||||..   .|||
  Rat   206 IITFKGVCTQAPCYCILMEFCAQGQLYEVLRAGRPVTPSLLVDWSMGIAGGMNYLHLH---KIIH 267

  Fly   250 RDLKSSNVLI-YEAIEGNHLQQKTLKITDFGLAREMYN-TQRMSAAGTYAWMPPEVISVSTYSKF 312
            |||||.|:|| |:.:         :||:|||.::|:.: :.:||.|||.|||.||||.....|:.
  Rat   268 RDLKSPNMLITYDDV---------VKISDFGTSKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEK 323

  Fly   313 SDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRP 377
            .|:||:||:||||:|||.|||..|..::.:||..|:|.||:|.:||:.:..|::.||...|..||
  Rat   324 VDIWSFGVVLWELLTGEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNRKPRNRP 388

  Fly   378 GFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEEL--RNKEEQ 440
            .|::||..|: ||.:....||||::...|..||:|:......::.:......:||||  |.:||.
  Rat   389 SFRQILLHLD-IASADVLSTPQETYFKSQAEWREEVKLHFEKIKSEGTCLHRLEEELVMRRREEL 452

  Fly   441 L----LRVQNEQR-EKANLLKIREQN-----LRERERVLIERELVMLQPVPSKRKHKKGKKNKPL 495
            .    :|...|:: |:||.|.: |.|     |..:||.|:.||..:.:..|...|....:
  Rat   453 RHALDIREHYERKLERANNLYM-ELNALMLQLELKERELLRREQALERRCPGLLKSHTSR----- 511

  Fly   496 QISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLP---SQLS 557
              ||..|  :|:..:..|...|...|....|              |..:  :..||||   :.||
  Rat   512 --SLLHG--NTMEKLIKKRNVPQKLSPHSKR--------------PDIL--KTESLLPKLDAALS 556

  Fly   558 G-GQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVAS-------------LTPPPGLGILGGSG 608
            | |.|..|          |:.|:..:.::.:.:.:.||             ..||...|.||..|
  Rat   557 GVGLPGCP----------KAPPSPGRSRRGKTRHRKASAKGSCGDLPGLRAALPPHEPGGLGSPG 611

  Fly   609 GAGGTP----ATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNN 669
            |.|..|    |:|....|:                                          :::.
  Rat   612 GLGVGPTAWDASPPALRGL------------------------------------------HHDL 634

  Fly   670 QLNNISTINSNNNNNQTNLTSQPNTIIVL--QNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPL 732
            .|..:|             :|.|:.:...  ..||..:..:....||
  Rat   635 LLRKMS-------------SSSPDLLSAALGARGRGATGGARDPGSP------------------ 668

  Fly   733 AYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLD 797
               |||         :.||..|            ..:|.|:......||:.|..|
  Rat   669 ---PPP---------QGDTPPS------------EGSAPGSTSPDSPGGAKGEPP---------- 699

  Fly   798 SSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSST 862
                 ||........|                           :.:.....:...|....|...|
  Rat   700 -----PPVGPGEGVGL---------------------------LGTGREGTTGRGGSRAGYQHLT 732

  Fly   863 PLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEAEDEDAVAAEVDTADADADDECQ 927
            |                        :........||.::.|.:.:|:         :.:.|.|.:
  Rat   733 P------------------------AALLYRAAVTRSQKRGISSEEE---------EGEVDSEVE 764

  Fly   928 VPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFATYRSASPSLSSSS 992
            :|.||........|:|..||.|   |.|           ||:...:||         .||.|.:.
  Rat   765 LPPSQRWPQGPNMRQSLSTFSS---ENP-----------SDVEEGTAS---------EPSPSGTP 806

  Fly   993 TTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQRQQTKNQKKQ--RPKHI 1055
            ...|.:......|..:....|.:.|.......:|.|..:...|..|.|..|..|.:..  ....:
  Rat   807 EVGSTNTDERPDERSDDMCSQGSEIPLDLPTSEVVPERETSSLPMQHQDDQGPNPEDSDCDSTEL 871

  Fly  1056 TKSKSVEA 1063
            ..|.|::|
  Rat   872 DNSNSIDA 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	107/261 (41%)
		STKc_MLK	134..389	CDD:270963	108/259 (42%)
Map3k12	NP_037187.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..104
		STKc_MAP3K12_13	164..400	CDD:270961	108/259 (42%)
		TyrKc	165..397	CDD:197581	107/254 (42%)
		Leucine-zipper 1	423..444		2/20 (10%)
		Leucine-zipper 2	476..497		7/20 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..620		17/72 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..731		21/160 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	743..888		37/169 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	4.010