Protein Alignment slpr and ANKK1

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_011541038.1
• Gene: ANKK1 / 255239
• HGNCID: 21027
• Length: 776
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 131/558 - (23%)
• Similarity: 229/558 - (41%)
• Gaps: 119/558 - (21%)

  Fly   106 DPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKV----HRGYYDGEEVAIKIAHQTGEDDM 166
            ||.:|.    :|.:.....:..|.|.: ::.||||.:|    ||.:  ..|.|||.|.....|..
Human     4 DPTELR----LGSLPVFTRDDFEGDWR-LVASGGFSQVFQARHRRW--RTEYAIKCAPCLPPDAA 61

  Fly   167 QRMRDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAGKIPPDVLVNWAI- 230
            ....:.:::||.....:|.::|.::.||| ...|.:|||:...|||.::|:..     .:.|.:
Human    62 SSDVNYLIEEAAKMKKIKFQHIVSIYGVC-KQPLGIVMEFMANGSLEKVLSTH-----SLCWKLR 120

  Fly   231 -----QIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGN-HLQQKTLKITDFGLAREMYNTQR 289
                 :.:..||:||:..| .::|.|||..|:|    ::.| |     :||:||||::.|..:.|
Human   121 FRIIHETSLAMNFLHSIKP-PLLHLDLKPGNIL----LDSNMH-----VKISDFGLSKWMEQSTR 175

  Fly   290 M------SAAGTYAWMPPEVISVSTYS---KFSDVWSYGVLLWELITGETPY----------KGF 335
            |      :..|..:::|||:...|..:   |: ||:|:.:::|||:|.:.||          |||
Human   176 MQYIERSALRGMLSYIPPEMFLESNKAPGPKY-DVYSFAIVIWELLTQKKPYSELTSQLKERKGF 239

  Fly   336 DPLSVAYGVAVNTLTLPIPKTCPETWGA-------LMKSCWQTDPHKRPGFKEILKQ---LESIA 390
            :.:.:...||..  ..|..:...:.|.:       |||.||..||.|||.|.:|..:   |.|:.
Human   240 NMMMIIIRVAAG--MRPSLQPVSDQWPSEAQQMVDLMKRCWDQDPKKRPCFLDITIETDILLSLL 302

  Fly   391 CSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKEE--QLLRVQNEQREKAN 453
            .|:..:...::......|        ...||:..:..:.|.:||.:..:  ..|:...:..::.|
Human   303 QSRVAVPESKALARKVSC--------KLSLRQPGEVNEDISQELMDSADSGNYLKRALQLSDRKN 359

  Fly   454 LLKIREQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQISL------------PTGFRHT 506
            |:.      |:.|..:.|.::..|        |....:....|:.|            .:|:...
Human   360 LVP------RDEELCIYENKVTPL--------HFLVAQGSVEQVRLLLAHEVDVDCQTASGYTPL 410

  Fly   507 ITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMH--------QRERSLLPSQLSGGQPE- 562
            :.|.:|:     .|....|.:....|.::....|.:.:|        ...|.||.........|
Human   411 LIAAQDQ-----QPDLCALLLAHGADANRVDEDGWAPLHFAAQNGDDGTARLLLDHGACVDAQER 470

  Fly   563 --W-PAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTP 597
              | |...:..::|...|..|..:|...|..:....||
Human   471 EGWTPLHLAAQNNFENVARLLVSRQADPNLHEAEGKTP 508

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		STKc_MLK	134..389	CDD:270963	86/294 (29%)
ANKK1	XP_011541038.1	STKc_RIP4_like	25..303	CDD:270927	87/299 (29%)
		ANKYR	364..629	CDD:440430	27/158 (17%)
		ANK repeat	375..403	CDD:293786	4/35 (11%)
		ANK repeat	405..436	CDD:293786	6/35 (17%)
		ANK repeat	438..469	CDD:293786	5/30 (17%)
		ANK repeat	471..502	CDD:293786	7/30 (23%)
		ANK repeat	504..534	CDD:293786	2/5 (40%)
		ANKYR	518..758	CDD:440430
		ANK repeat	537..568	CDD:293786
		ANK repeat	570..601	CDD:293786
		ANK repeat	603..634	CDD:293786
		ANK repeat	638..667	CDD:293786
		ANK repeat	669..700	CDD:293786
		ANK repeat	702..733	CDD:293786