Protein Alignment slpr and ABL1

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_009297.2
• Gene: ABL1 / 25
• HGNCID: 76
• Length: 1149
• Species: Homo sapiens
• Alignment Length: 1234
• Identity: 271/1234 - (21%)
• Similarity: 420/1234 - (34%)
• Gaps: 409/1234 - (33%)

  Fly    44 DGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVT----- 103
            |.:|:.||||:.|.|::.|::.:||.:.||..:.  :|:  |...:..:..|..|.:::|
Human    81 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNH--NGE--WCEAQTKNGQGWVPSNYITPVNSL 141

  Fly   104 --------------------------------DEDPLQLNVS----------------------- 113
                                            :..|.|.::|
Human   142 EKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVS 206

  Fly   114 ---------------SAIGD--------------------IQPH----EIEYNELDIKEVIGSGG 139
                           |.:.|                    :.|:    |:|..::.:|..:|.|.
Human   207 SESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQ 271

  Fly   140 FCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLV 203
            :.:|:.|.:  ::.::.:|.:|.::|...: :..|:||.:...:||.|:..|.|||. .....::
Human   272 YGEVYEGVW--KKYSLTVAVKTLKEDTMEV-EEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYII 333

  Fly   204 MEYARGGSL-------NRILAGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYE 261
            .|:...|:|       ||   .::...||:..|.||:..|.||..:   :.|||||.:.|.|:.|
Human   334 TEFMTYGNLLDYLRECNR---QEVNAVVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGE 392

  Fly   262 AIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGT---YAWMPPEVISVSTYSKFSDVWSYGVLLW 323
                |||    :|:.||||:|.|......:.||.   ..|..||.::.:.:|..||||::|||||
Human   393 ----NHL----VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLW 449

  Fly   324 ELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLE 387
            |:.| |.:||.|.| ||..|.:......:..|:.|||....||::|||.:|..||.|.||.:..|
Human   450 EIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFE 513

  Fly   388 SIACSKFTLTPQESF---HYMQECWRKEIAGVLHDL--------------REKEKRFQT-IEEEL 434
            ::.        |||.   ...:|..::.:.|.:..|              |..|.|..| :.|..
Human   514 TMF--------QESSISDEVEKELGKQGVRGAVSTLLQAPELPTKTRTSRRAAEHRDTTDVPEMP 570

  Fly   435 RNKEEQLLRVQNEQREKANLLKIREQ-----NLRERERVLIERELVMLQPVPSKRKH-------K 487
            .:|.:......:.:...:.||..:|:     .|.|.||:|           |..:|.       |
Human   571 HSKGQGESDPLDHEPAVSPLLPRKERGPPEGGLNEDERLL-----------PKDKKTNLFSALIK 624

  Fly   488 KGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGK-TWGPSTMHQRERSL 551
            |.||..|......:.||          |..|.|...|.......|...|. .:.|.......:|.
Human   625 KKKKTAPTPPKRSSSFR----------EMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSP 679

  Fly   552 LPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPAT 616
            .||. ..|.|....:.|..|.|  .:|:|.||.......::|:           |....||:.:.
Human   680 KPSN-GAGVPNGALRESGGSGF--RSPHLWKKSSTLTSSRLAT-----------GEEEGGGSSSK 730

  Fly   617 PLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNN 681
            ..|                .:|.|                                  |.:....
Human   731 RFL----------------RSCSA----------------------------------SCVPHGA 745

  Fly   682 NNNQTNLTSQPNTIIVLQNGRNNSNSST----TSQSPAKIYHRARSQEYGLDHPL--AYQPPPLY 740
            .:.:....:.|..   ||:.....:|||    .|:.||  ..|.|:.|...|...  ...||| .
Human   746 KDTEWRSVTLPRD---LQSTGRQFDSSTFGGHKSEKPA--LPRKRAGENRSDQVTRGTVTPPP-R 804

  Fly   741 LVTDDSSETDTV------ASPTGCFHFLKSGNS---------------SAASGAVHLHRFG-GSL 783
            ||..:....|.|      :||         |:|               :.|||..|....| ||.
Human   805 LVKKNEEAADEVFKDIMESSP---------GSSPPNLTPKPLRRQVTVAPASGLPHKEEAGKGSA 860

  Fly   784 GNSPAVGRKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVN 848
            ..:||..........:....|...|..         |:|::....|        |.|..|..|..
Human   861 LGTPAAAEPVTPTSKAGSGAPGGTSKG---------PAEESRVRRH--------KHSSESPGRDK 908

  Fly   849 SKSSGDLTMYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEA--EDEDAV 911
            .|.|   .:..:..|..|.....|     ||:      .||.|      .||..|||  ..:...
Human   909 GKLS---RLKPAPPPPPAASAGKA-----GGK------PSQSP------SQEAAGEAVLGAKTKA 953

  Fly   912 AAEVDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASI 976
            .:.||..::||....| |...::                   :|...|||:..:..   .|...|
Human   954 TSLVDAVNSDAAKPSQ-PGEGLK-------------------KPVLPATPKPQSAK---PSGTPI 995

  Fly   977 SFATYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHPDVIKLRAQEQR 1041
            |.|...|..|  |:||..|...||  ||..:        .:::||           :.||
Human   996 SPAPVPSTLP--SASSALAGDQPS--STAFI--------PLISTR-----------VSLR----- 1032

  Fly  1042 QQTKNQKKQRPKHITKSKSVEAPVEGQHHEHDD-------HNDPQHQHHSAGSSKIRALFNLFT 1098
                 :.:|.|:.|...    |..:|...:..:       .|..|...|||   .:.|..||:|
Human  1033 -----KTRQPPERIASG----AITKGVVLDSTEALCLAISRNSEQMASHSA---VLEAGKNLYT 1084

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	17/93 (18%)
		STKc_MLK	134..389	CDD:270963	89/266 (33%)
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784	16/56 (29%)
		SH2_ABL	142..235	CDD:198189	5/92 (5%)
		PTKc_Abl	254..516	CDD:270645	92/279 (33%)
		FABD	1025..1149	CDD:197885	18/88 (20%)