DRSC/TRiP Functional Genomics Resources

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Protein Alignment slpr and Ripk3

DIOPT Version :9

Sequence 1:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_647558.2 Gene:Ripk3 / 246240 RGDID:628899 Length:478 Species:Rattus norvegicus


Alignment Length:518 Identity:128/518 - (24%)
Similarity:200/518 - (38%) Gaps:137/518 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 LQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYD--GEEVAIKIAHQTGEDDMQRMR 170
            |.||.:|:|..:...|:|  .|..   :|.|||..|.|..:.  ..:||:||.:.          
  Rat     6 LWLNGASSISLVGSEELE--NLGF---VGKGGFGAVFRARHTAWNLDVAVKIVNS---------- 55

  Fly   171 DNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSL------NRILAGKIPPDVLVNWA 229
            ..:.:|.|....|:|||:..|.||..|    |..:|..|.:|      |..|:|.:.|.....|.
  Rat    56 KKISREVKAMVNLRHENVLLLLGVTEN----LEWDYVYGPALVTGFMENGSLSGLLQPSCPRPWP 116

  Fly   230 I------QIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQ 288
            :      ::..||.|||:..| |::|||||.||||:...:..        |:.||||:.....:|
  Rat   117 LLCRLLEEVVLGMCYLHSLNP-SLLHRDLKPSNVLLDPELHA--------KLADFGLSTFQGGSQ 172

  Fly   289 RMS------AAGTYAWMPPEVI-SVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAV 346
            ..|      :.||.|::.||:: :....||.|||:|:|||:|.::.|... :..|..|:..|...
  Rat   173 SGSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVWTVLAGREA-EVVDKTSLIRGAVC 236

  Fly   347 NTLTLP----IPKTCPETWG-----ALMKSCWQTDPHKRPGFKEILKQLESI----------ACS 392
            |....|    :|...|||.|     .||..||.::|..||.|::...:..::          |.|
  Rat   237 NRQRRPPLTELPPDSPETPGLEGLKELMTHCWSSEPKDRPSFQDCESKTNNVYILVQDKVDAAVS 301

  Fly   393 KFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKI 457
            |..       ||:.:            .|..:.:....|...:..|....| :....|..:.|.:
  Rat   302 KVK-------HYLSQ------------YRSSDTKLSARESSQKGTEVDCPR-ETIVYEMLDRLHL 346

  Fly   458 REQ--NLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSP 520
            .|.  ::.||...|.||               :||:         ..|.|...|........|:|
  Rat   347 EEPSGSVPERLTSLTER---------------RGKE---------ASFGHATPAGTSSDTLAGTP 387

  Fly   521 SFSGLRIVALTDGHKGKTWGPSTMHQRERSLLP--SQLSGGQPEWPAQTSTHSS--FSKSAPN 579
            ..                  |.|:..|..:..|  ::..|..|:.......:|:  ::.:|||
  Rat   388 QI------------------PHTLPSRGTTPRPAFTETPGPDPQRNQGDGRNSNPWYTWNAPN 432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809
TyrKc 129..386 CDD:197581 87/286 (30%)
STKc_MLK 134..389 CDD:270963 86/284 (30%)
Ripk3NP_647558.2 PKc_like 28..285 CDD:419665 86/280 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 311..330 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 362..429 16/108 (15%)
RHIM 408..458 CDD:403811 6/25 (24%)
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000250|UniProtKB:Q9Y572 437..461
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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