Protein Alignment slpr and FRK

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_002022.1
• Gene: FRK / 2444
• HGNCID: 3955
• Length: 505
• Species: Homo sapiens
• Alignment Length: 468
• Identity: 118/468 - (25%)
• Similarity: 180/468 - (38%)
• Gaps: 148/468 - (31%)

  Fly    45 GSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDK---------VGVFPKD 100
            |..:.||:||.|:..::|:.|.|:.:.||.|..|     |||..:..:|         .|..|.:
Human    44 GHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHE-----GWWFARHLEKRRDGSSQQLQGYIPSN 103

  Fly   101 FVTDEDPLQL------------------------------------------------------- 110
            :|.::..||.
Human   104 YVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIK 168

  Fly   111 ------------NVSSAIGDIQPH-----------------------------------EIEYNE 128
                        .:.|.:.:...|                                   ||:.|.
Human   169 RLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNS 233

  Fly   129 LDIKEVIGSGGFCKVHRGYYDG-EEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALR 192
            :.:.:.:|||.|.:|..|.::. ..||:|.......|.     ::.|:||::...|:|..:..|.
Human   234 IQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDP-----NDFLREAQIMKNLRHPKLIQLY 293

  Fly   193 GVC-LNTKLCLVMEYARGGSLNRIL----AGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDL 252
            .|| |...:.::.|..|.|||...|    ..||.....|:.|.|:|.||.||.:.   :.|||||
Human   294 AVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESR---NYIHRDL 355

  Fly   253 KSSNVLIYEAIEGNHLQQKTLKITDFGLAR-------EMYNTQRMSAAGTYAWMPPEVISVSTYS 310
            .:.|||:     |.|   ...|:.||||||       ::|.: |........|..||.|..:.:|
Human   356 AARNVLV-----GEH---NIYKVADFGLARVFKVDNEDIYES-RHEIKLPVKWTAPEAIRSNKFS 411

  Fly   311 KFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPH 374
            ..|||||:|:||:|:|| |:.||.|.....|...:|.| ..||.|..||:.:..:|..||..:|.
Human   412 IKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQN-YRLPQPSNCPQQFYNIMLECWNAEPK 475

  Fly   375 KRPGFKEILKQLE 387
            :||.|:.:..:||
Human   476 ERPTFETLRWKLE 488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	19/65 (29%)
		STKc_MLK	134..389	CDD:270963	91/268 (34%)
FRK	NP_002022.1	SH3_Src_like	47..104	CDD:212779	18/61 (30%)
		SH2_Src_Frk	112..207	CDD:199831	3/94 (3%)
		PTKc_Frk_like	225..494	CDD:270653	94/282 (33%)