DRSC/TRiP Functional Genomics Resources

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Protein Alignment slpr and Map3k21

DIOPT Version :9

Sequence 1:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_663583.2 Gene:Map3k21 / 234878 MGIID:2385307 Length:1002 Species:Mus musculus


Alignment Length:1033 Identity:348/1033 - (33%)
Similarity:488/1033 - (47%) Gaps:180/1033 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    47 LWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQLN 111
            :|.|||||:|:|||||:||||::|.|||.|:.||||.|||.|::..::|:||..:|....|:...
Mouse    28 MWAALYDYEARGEDELSLRRGQLVEVLSQDAAVSGDEGWWAGQVQRRLGIFPASYVAPCGPVPPP 92

  Fly   112 VSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQE 176
            .........|..:::..|::||:||:|||.:|:|..:.|:|||:|.|.:..|.|.....::|.:|
Mouse    93 APPPPRPCSPVHVDFERLELKELIGAGGFGQVYRATWQGQEVAVKAARRDPEQDAAAAAESVRRE 157

  Fly   177 AKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAG--------------KIPPDVLV 226
            |:||..|:|.||..|||||| ...||||:|:||||:|||.||.              :|||.|||
Mouse   158 ARLFAMLRHPNIIQLRGVCLRQPHLCLVLEFARGGALNRALAAAASDPRAPGPRRARRIPPQVLV 222

  Fly   227 NWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMS 291
            |||:||||||.|||.||.:.|:||||||||:|:.|.||.:.:..|||||||||||||.:.|.|||
Mouse   223 NWAVQIARGMLYLHEEAVVPILHRDLKSSNILLLEKIEHDDICNKTLKITDFGLAREWHRTTRMS 287

  Fly   292 AAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKT 356
            ||||||||.||||..|.:||.||:||||||||||:|||.||:|.|.|:||||||||.||||||.|
Mouse   288 AAGTYAWMAPEVIRSSLFSKGSDIWSYGVLLWELLTGEVPYRGIDGLAVAYGVAVNKLTLPIPST 352

  Fly   357 CPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLR 421
            |||.:..|||.||:.|||.||.|..||:||.:|..:..|..||||||.|||.|:.||..:..:||
Mouse   353 CPEPFAKLMKECWEQDPHIRPSFALILQQLTAIEEAVLTNMPQESFHSMQEDWKLEIQQMFSELR 417

  Fly   422 EKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVML-----QPVP 481
            .|||       |||::||:|.|...:|:.:..||:.|||.|.|||..::||||.:|     |..|
Mouse   418 TKEK-------ELRSREEELSRAALQQKSQELLLRRREQQLAEREIDVLERELNVLIFQLSQEAP 475

  Fly   482 SKRKHKKGKKNKPL------QISLPTGFRHTITA----VRDK--------AEQPGSP-SFSGLRI 527
            ..:|.|...:...|      :||||:.|:|.||.    ..||        ...|||| ....||.
Mouse   476 HVKKRKGRFRRGRLRLKDGHRISLPSDFQHKITVQASPTLDKRRSSDSGLCSPPGSPLMLPRLRA 540

  Fly   528 VALTDGH-------------------------KGKTWGPSTMHQRERSLLPS------QLSGGQP 561
            :.||...                         ||.|||||::..:||   |.      .||.|..
Mouse   541 IQLTSDENNKTRGRNMVFRQEDFEDVKRSFKKKGCTWGPSSVQTKER---PEGRERVRPLSDGNS 602

  Fly   562 EWPA------QTSTHSSFSKSAPNLDKKQQ---QQNQQQVASLTPPPGLGILG------------ 605
            .|.:      :|:..:|.....|...::|:   :..:.:....|..||...:|            
Mouse   603 PWSSLLIKSQKTTPLASLFVDQPGSCEEQKLVPEGLEHRKPKQTKFPGQAHVGLPLCKDSQREDS 667

  Fly   606 ---GSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANN 667
               .|...|....:|:...|.| :|.:...:.:..|..:..::.........:........|...
Mouse   668 SEAESREEGSPKGSPVNNVGAP-MLRKKTESALCECGMLLASMALGLDVRKLHGAQAPAKPSPKM 731

  Fly   668 NNQLNNISTINSNNNNNQTNLTSQPN--------TIIVLQNGRNNSNSSTTSQSPAKIYHRARSQ 724
            ..:........|...::.::|..||:        :.::|.:..::|:.|:.|.   |...:|..:
Mouse   732 EKKEEGALQPASRCQSSPSSLLRQPSAGRAPSGGSTLLLPSAPSHSSKSSLSM---KCLLQAGKE 793

  Fly   725 EYGLDH------PLAYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSL 783
            |..|.:      |....|.|.....:...|......|...:..|:|...:.      |.:.|..|
Mouse   794 ESSLGNARDLCGPTTLTPDPGSAAPESGCELIPGLRPKTDYGVLRSMPHAI------LEQTGERL 852

  Fly   784 GNSPAVGRKK-HSLDSSSHHPP---ANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASS 844
            .....||.|. |.:...|...|   .:......||:.   ||....       ||:..:.|:...
Mouse   853 PGCAIVGDKGCHHMQMGSEETPLWLQSAPEDSGLPHS---PSPGPQ-------RDLASQASLVKP 907

  Fly   845 ERVNSKSSG---------DLTMYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQE 900
            |.|..:...         ..::..:|.|....|.|                 .|.|........:
Mouse   908 EGVLGECQACPALPQRPHTASVRTTSPPTWVCDKD-----------------HQVPALACLLGAQ 955

  Fly   901 EEGEAEDEDAVAAEVDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFV 958
            |....:....:.|.::....|    |.:|..::        ||.:...|:...|.||:
Mouse   956 ERSRCQTPSLLDASIEGQKKD----CAMPLCRV--------KSVMCQPSIYALEKDFL 1001

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809 33/56 (59%)
TyrKc 129..386 CDD:197581 163/271 (60%)
STKc_MLK 134..389 CDD:270963 162/269 (60%)
Map3k21NP_663583.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..26
SH3 28..82 CDD:302595 32/53 (60%)
TyrKc 110..382 CDD:197581 163/271 (60%)
PKc_like 115..385 CDD:304357 162/269 (60%)
Leucine-zipper 1 409..430 11/27 (41%)
Leucine-zipper 2 444..466 12/21 (57%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 508..531 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 574..604 12/32 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 640..689 8/48 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 721..778 6/56 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 797..823 4/25 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 878..899 6/30 (20%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 340 1.000 Domainoid score I1088
eggNOG 1 0.900 - - E2759_KOG0192
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0001334
OrthoInspector 1 1.000 - - otm44249
orthoMCL 1 0.900 - - OOG6_100013
Panther 1 1.100 - - LDO PTHR44329
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X88
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
98.770

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