Protein Alignment slpr and Txk

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_036020891.1
• Gene: Txk / 22165
• MGIID: 102960
• Length: 543
• Species: Mus musculus
• Alignment Length: 520
• Identity: 125/520 - (24%)
• Similarity: 198/520 - (38%)
• Gaps: 176/520 - (33%)

  Fly     2 LPISEEQQLQQQQQQQQ--------------------LEQLHHPQIPEIPIPDLEQVETQVGDGS 46
            :.:|.|::|.::..|:|                    .::...|.:|:.| || |:::.:
Mouse    60 ISLSREEELSEKHSQRQRPWFAKLMGKTQSNRGGVQPSKRKPLPPLPQEP-PD-ERIQVK----- 117

  Fly    47 LWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTG--KIGDKVGVFPKDFVTDEDPLQ 109
               ||||:..:....|.|:|.|..::|.     ..|..||..  :.|:: |:.|.::||:.....
Mouse   118 ---ALYDFLPREPGNLALKRAEEYLILE-----RCDPHWWKARDRFGNE-GLIPSNYVTENRLAN 173

  Fly   110 LNV------------------------------SSAIGD-------------------------- 118
            |.:                              |..:|.
Mouse   174 LEIYEWYHKNITRNQTERLLRQEAKEGAFIVRDSRHLGSYTISVFTRARRHTQSSIKHYQIKKND 238

  Fly   119 ------------------IQPH---------------------------------EIEYNELDIK 132
                              ||.|                                 ||:.:||...
Mouse   239 SGQWYITERHLFPSVPELIQYHQYNAAGLISRLRYPIGLLGSCLPATSGFSYEKWEIDPSELAFV 303

  Fly   133 EVIGSGGFCKVHRGYYDGE-EVAIKIAHQ--TGEDDMQRMRDNVLQEAKLFWALKHENIAALRGV 194
            :.||||.|..||.|.:... .||||..::  ..|:|.       ::|||:...|.|..:..|.||
Mouse   304 KEIGSGQFGVVHLGEWRAHIPVAIKAINEGSMSEEDF-------IEEAKVMMKLSHSRLVQLYGV 361

  Fly   195 CLNTK-LCLVMEYARGGSLNRIL---AGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSS 255
            |:..| |.:|.|:...|.|...|   .|::...:|::....|..||.||....   .|||||.:.
Mouse   362 CIQQKPLYIVTEFMENGCLLDYLRERKGQLQKALLLSMCQDICEGMAYLERSC---YIHRDLAAR 423

  Fly   256 NVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGT---YAWMPPEVISVSTYSKFSDVWS 317
            |.|:..|.        .:||:|||:||.:.:.:.:|::|.   ..|.||||...:.||..|||||
Mouse   424 NCLVSSAC--------VVKISDFGMARYVLDDEYISSSGAKFPVKWCPPEVFHFNKYSSKSDVWS 480

  Fly   318 YGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKE 381
            :|||:||:.| |:.|::....|.|...:: ....|..|...|.|...:|.|||. :..::|.|:|
Mouse   481 FGVLMWEVFTEGKMPFENKSNLQVVEAIS-QGFRLYRPHLAPMTIYRVMYSCWH-ETLQKPVFQE 543

  Fly   382  381
            Mouse   544  543

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	16/58 (28%)
		STKc_MLK	134..389	CDD:270963	87/259 (34%)
Txk	XP_036020891.1	SH3_TXK	114..168	CDD:212840	16/67 (24%)
		SH2_Tec_Txk	172..277	CDD:198261	6/104 (6%)
		Protein Kinases, catalytic domain	295..543	CDD:473864	89/267 (33%)