DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and Ripk1

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001346926.1	Gene:	Ripk1 / 19766	MGIID:	108212	Length:	656	Species:	Mus musculus

Alignment Length:	655	Identity:	153/655 - (23%)
Similarity:	247/655 - (37%)	Gaps:	170/655 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 NVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQ 175
            |:..|..|:    :|..:||      ||||.||...|:......|.....||.:..: ..:.:|:
Mouse     9 NIKMASSDL----LEKTDLD------SGGFGKVSLCYHRSHGFVILKKVYTGPNRAE-YNEVLLE 62

  Fly   176 EAKLFWALKHENIAALRGVCLNT-KLCLVMEYARGGSLNRILAGKI--PPDVLVNWAIQIARGMN 237
            |.|:...|:|..:..|.|:.:.. ...|||||...|:|..:|..:|  |..:.....::...||.
Mouse    63 EGKMMHRLRHSRVVKLLGIIIEEGNYSLVMEYMEKGNLMHVLKTQIDVPLSLKGRIIVEAIEGMC 127

  Fly   238 YLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLA----------------REMYN 286
            |||::   .:||:|||..|:|:.....        :||.|.|:|                :|:.:
Mouse   128 YLHDK---GVIHKDLKPENILVDRDFH--------IKIADLGVASFKTWSKLTKEKDNKQKEVSS 181

  Fly   287 TQRMSAAGTYAWMPPE---VISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNT 348
            |.:.:..||..:|.||   .|:.....| |||:|:|::||.:...:.||:.. ..:..:.:.:.:
Mouse   182 TTKKNNGGTLYYMAPEHLNDINAKPTEK-SDVYSFGIVLWAIFAKKEPYENV-ICTEQFVICIKS 244

  Fly   349 LTLP----IPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKF--------------- 394
            ...|    |.:.||....:||:.|||..|..||.|..|.::......|.|
Mouse   245 GNRPNVEEILEYCPREIISLMERCWQAIPEDRPTFLGIEEEFRPFYLSHFEEYVEEDVASLKKEY 309

  Fly   395 -TLTP--QESFHYMQEC-------WRKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQR 449
             ..:|  |..|....:|       ...|..|.||.  .:..:...:||...:...:..:.:|::.
Mouse   310 PDQSPVLQRMFSLQHDCVPLPPSRSNSEQPGSLHS--SQGLQMGPVEESWFSSSPEYPQDENDRS 372

  Fly   450 EKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKA 514
            .:|   |::|:.......:..|::   .:|.|.:.:....::.:..::|      |...|.:...
Mouse   373 VQA---KLQEEASYHAFGIFAEKQ---TKPQPRQNEAYNREEERKRRVS------HDPFAQQRAR 425

  Fly   515 EQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPA-QTSTHSSFSKS-- 576
            |...|   :|.|      ||.    .|||   ..|.:...|||     ||| ||..::.....
Mouse   426 ENIKS---AGAR------GHS----DPST---TSRGIAVQQLS-----WPATQTVWNNGLYNQHG 469

  Fly   577 ----------APNLDKKQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATP----------LLY- 620
                      .|||       :|......||.|...|      .|.||..|          :.|
Mouse   470 FGTTGTGVWYPPNL-------SQMYSTYKTPVPETNI------PGSTPTMPYFSGPVADDLIKYT 521

  Fly   621 ----PGIPI---------ILTRPNNNNIGNCKAITTT----ITTTTTTTTNNNNNNNNSISANNN 668
                .||.|         :.::|.||   .||..:|:    |...||:.|   :.:.|.|..|..
Mouse   522 IFNSSGIQIGNHNYMDVGLNSQPPNN---TCKEESTSRHQAIFDNTTSLT---DEHLNPIRENLG 580

  Fly   669 NQLNN 673
            .|..|
Mouse   581 RQWKN 585

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	78/282 (28%)
		STKc_MLK	134..389	CDD:270963	76/280 (27%)
Ripk1	NP_001346926.1	PKc_like	23..291	CDD:419665	78/287 (27%)
		Interaction with SQSTM1. /evidence=ECO:0000250\|UniProtKB:Q13546	291..567		65/326 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..373		7/47 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..423		6/43 (14%)
		RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269\|PubMed:18442983, ECO:0000269\|PubMed:27819681, ECO:0000269\|PubMed:27819682	520..536		4/15 (27%)
		Death_RIP1	568..653	CDD:260048	6/21 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.810