DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and MLKL

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_689862.1	Gene:	MLKL / 197259	HGNCID:	26617	Length:	471	Species:	Homo sapiens

Alignment Length:	267	Identity:	76/267 - (28%)
Similarity:	128/267 - (47%)	Gaps:	32/267 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 VHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLN-----TKLCL 202
            :::|.|....||||:..:.....:..:|....:|.|.....:..||..:.|:|::     .:..:
Human   217 LYKGEYHRAPVAIKVFKKLQAGSIAIVRQTFNKEIKTMKKFESPNILRIFGICIDETVTPPQFSI 281

  Fly   203 VMEYARGGSLNRIL-------AGKIPPDVLVNWAIQIARGMNYL-HNEAPMSIIHRDLKSSNVLI 259
            ||||...|:|..:|       .||  ..|||   :..|||:..| |:|||.  :|..::|||.|:
Human   282 VMEYCELGTLRELLDREKDLTLGK--RMVLV---LGAARGLYRLHHSEAPE--LHGKIRSSNFLV 339

  Fly   260 YEA----IEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVIS--VSTYSKFSDVWSY 318
            .:.    :.|..| :||......|..||  .|.|:.:.   |::.|:.:.  ...|...|:::|:
Human   340 TQGYQVKLAGFEL-RKTQTSMSLGTTRE--KTDRVKST---AYLSPQELEDVFYQYDVKSEIYSF 398

  Fly   319 GVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEIL 383
            |::|||:.||:.|::|.:...:...|||.....|:.:.||.....::..|...||..||...|||
Human   399 GIVLWEIATGDIPFQGCNSEKIRKLVAVKRQQEPLGEDCPSELREIIDECRAHDPSVRPSVDEIL 463

  Fly   384 KQLESIA 390
            |:|.:.:
Human   464 KKLSTFS 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	75/261 (29%)
		STKc_MLK	134..389	CDD:270963	76/264 (29%)
MLKL	NP_689862.1	N-terminal bundle and brace (NBB), mediates INSP6 binding. /evidence=ECO:0000269\|PubMed:29883610	1..149
		PHA02988	177..469	CDD:165291	76/264 (29%)
		PKc_like	215..466	CDD:304357	75/261 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.900