Protein Alignment slpr and EGFR

DIOPT Version :9

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_005219.2
• Gene: EGFR / 1956
• HGNCID: 3236
• Length: 1210
• Species: Homo sapiens
• Alignment Length: 509
• Identity: 128/509 - (25%)
• Similarity: 204/509 - (40%)
• Gaps: 119/509 - (23%)

  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYY--DGEEVAIKIA-HQTGEDDMQRMRDNVLQEAKLFWALK 184
            |.|:.::   :|:|||.|..|::|.:  :||:|.|.:| .:..|....:....:|.||.:..::.
Human   709 ETEFKKI---KVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVD 770

  Fly   185 HENIAALRGVCLNTKLCLV---------MEYARGGSLNRILAGKIPPDVLVNWAIQIARGMNYLH 240
            :.::..|.|:||.:.:.|:         ::|.|....|      |....|:||.:|||:|||||.
Human   771 NPHVCRLLGICLTSTVQLITQLMPFGCLLDYVREHKDN------IGSQYLLNWCVQIAKGMNYLE 829

  Fly   241 NEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKT---LKITDFGLAREM-YNTQRMSAAG---TYAW 298
            :.   .::||||.:.|||:           ||   :||||||||:.: ...:...|.|   ...|
Human   830 DR---RLVHRDLAARNVLV-----------KTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKW 880

  Fly   299 MPPEVISVSTYSKFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWG 362
            |..|.|....|:..||||||||.:|||:| |..||.|. |.|....:......||.|..|.....
Human   881 MALESILHRIYTHQSDVWSYGVTVWELMTFGSKPYDGI-PASEISSILEKGERLPQPPICTIDVY 944

  Fly   363 ALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRF 427
            .:|..||..|...||.|:|::     |..||....||                          |:
Human   945 MIMVKCWMIDADSRPKFRELI-----IEFSKMARDPQ--------------------------RY 978

  Fly   428 QTIEEELR-----NKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHK 487
            ..|:.:.|     ..:....|...::.:..:::        :.:..||.::.....|..|:
Human   979 LVIQGDERMHLPSPTDSNFYRALMDEEDMDDVV--------DADEYLIPQQGFFSSPSTSR---- 1031

  Fly   488 KGKKNKPLQISLPTGFRHTITAVRDKAEQPGSP--------SFSGLRIVALTDGHKGKTWGPSTM 544
                 .||..||.....::..|..|:......|        .:|.....|||:.....|:.|
Human  1032 -----TPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFLP--- 1088

  Fly   545 HQRERSLLPSQLSGGQPEWPAQTST----HSSFSKSAPNLDKKQQQQNQQQVAS 594
                   :|..::...|:.||.:..    |:.....||:.|...|..:...|.:
Human  1089 -------VPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGN 1135

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	90/276 (33%)
		STKc_MLK	134..389	CDD:270963	90/274 (33%)
EGFR	NP_005219.2	Recep_L_domain	57..168	CDD:279382
		Approximate	75..300
		Furin-like	185..335	CDD:279142
		FU	231..274	CDD:238021
		Recep_L_domain	361..481	CDD:279382
		Approximate	390..600
		GF_recep_IV	505..637	CDD:291509
		FU	506..559	CDD:238021
		FU	552..598	CDD:214589
		TM_ErbB1	634..677	CDD:213054
		Important for dimerization, phosphorylation and activation	688..704
		PTKc_EGFR	704..1016	CDD:270683	101/369 (27%)
		TyrKc	713..968	CDD:197581	91/283 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1097..1137		9/39 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000