DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and Ripk2

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_620402.1	Gene:	Ripk2 / 192656	MGIID:	1891456	Length:	539	Species:	Mus musculus

Alignment Length:	264	Identity:	84/264 - (31%)
Similarity:	135/264 - (51%)	Gaps:	41/264 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 VAIKIAH-QTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTK-LCLVMEYARGGSLNRI 215
            ||:|..| .|...|.:  |:::|:||::....:...|..:.|:|...: |.:|.||...||||.:
Mouse    44 VAVKHLHIHTPLLDSE--RNDILREAEILHKARFSYILPILGICNEPEFLGIVTEYMPNGSLNEL 106

  Fly   216 LAGKIP-PDVLVNWAI------QIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTL 273
            |..|.. ||:.  |.:      :||.|:|||||..| .::|.|||:.|:|:.....        :
Mouse   107 LHRKTEYPDIA--WPLRFRILHEIALGVNYLHNMNP-PLLHHDLKTQNILLDNEFH--------V 160

  Fly   274 KITDFGLA--REMYNTQRMS-----AAGTYAWMPPEVISVSTYSKFS---DVWSYGVLLWELITG 328
            ||.||||:  |.|..:|..|     ..||..:||||.......|:.|   |::||.|::||:::.
Mouse   161 KIADFGLSKWRMMSLSQSRSYKSAPEGGTIIYMPPENYEPGQKSRASVKHDIYSYAVIMWEVLSR 225

  Fly   329 ETPYKGF-DPLSVAYGVA----VNTLTLPIPKTCPETWG---ALMKSCWQTDPHKRPGFKEILKQ 385
            :.|::.. :||.:.|.|:    .:|....:|...|.. |   :|::|.|..:|.:||.|.:.|.:
Mouse   226 KQPFEEVTNPLQIMYSVSQGHRPDTSEENLPFDIPHR-GLMISLIQSGWAQNPDERPSFLKCLIE 289

  Fly   386 LESI 389
            ||.:
Mouse   290 LEPV 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	82/259 (32%)
		STKc_MLK	134..389	CDD:270963	84/262 (32%)
Ripk2	NP_620402.1	STKc_RIP2	20..303	CDD:270928	84/264 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..368
		CARD_RIP2_CARD3	437..522	CDD:176764
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..539
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44329
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910