Protein Alignment slpr and abl-1

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_509778.2
• Gene: abl-1 / 181261
• WormBaseID: WBGene00000018
• Length: 1224
• Species: Caenorhabditis elegans
• Alignment Length: 1152
• Identity: 245/1152 - (21%)
• Similarity: 402/1152 - (34%)
• Gaps: 366/1152 - (31%)

  Fly    32 IPDLEQVETQVGDGS-LWTALYDYDAQGEDELTLRRGEIVVVL--------------------ST 75
            :.|:..|.:.....: |:.||||:...||::|:||:|:.|.:|                    ::
 Worm   103 VHDMNTVSSSSSSSAPLFVALYDFHGVGEEQLSLRKGDQVRILGYNKNNEWCEARLYSTRKNDAS 167

  Fly    76 DSEVSGDVG-----------------WWTGKIG----------------------DKVGVF---- 97
            :....|::|                 |:.|||.                      ..:|.:
 Worm   168 NQRRLGEIGWVPSNFIAPYNSLDKYTWYHGKISRSDSEAILGSGITGSFLVRESETSIGQYTISV 232

  Fly    98 ----------------PKDFVTDE-----------------DPL---------QLNVSSAIGDIQ 120
                            .|.|:|.|                 |.|         :.:....:..:.
 Worm   233 RHDGRVFHYRINVDNTEKMFITQEVKFRTLGELVHHHSVHADGLICLLMYPASKKDKGRGLFSLS 297

  Fly   121 PHEIEYNELDIKEVI-----GSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLF 180
            |:..:..|||..|:|     |.|.:..|:.||:...:..|.:  :..::|...:.: .|.||.:.
 Worm   298 PNAPDEWELDRSEIIMHNKLGGGQYGDVYEGYWKRHDCTIAV--KALKEDAMPLHE-FLAEAAIM 359

  Fly   181 WALKHENIAALRGVCLN-TKLCLVMEYARGGS----LNRILAGKIPPDVLVNWAIQIARGMNYLH 240
            ..|.|:|:..|.|||.: ....::.|:...|:    |.|.....:||.:||..|.|||.||:||
 Worm   360 KDLHHKNLVRLLGVCTHEAPFYIITEFMCNGNLLEYLRRTDKSLLPPIILVQMASQIASGMSYL- 423

  Fly   241 NEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGT---YAWMPPE 302
             || ...|||||.:.|.|:.|        ...:||.||||||.|......:.||.   ..|..||
 Worm   424 -EA-RHFIHRDLAARNCLVSE--------HNIVKIADFGLARFMKEDTYTAHAGAKFPIKWTAPE 478

  Fly   303 VISVSTYSKFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMK 366
            .::.:|:|..||||::||||||:.| |..||.|.: ||..||:..|...:..|:.||.:...||.
 Worm   479 GLAFNTFSSKSDVWAFGVLLWEIATYGMAPYPGVE-LSNVYGLLENGFRMDGPQGCPPSVYRLML 542

  Fly   367 SCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIE 431
            .||...|..||.|::|...||::..|
 Worm   543 QCWNWSPSDRPRFRDIHFNLENLISS--------------------------------------- 568

  Fly   432 EELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQ 496
            ..|.::.::.|:..|:::.:::.   |..|:|||.              .||.:|.........:
 Worm   569 NSLNDEVQKQLKKNNDKKLESDK---RRSNVRERS--------------DSKSRHSSHHDRDRDR 616

  Fly   497 ISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQP 561
            .||           ..:...|..|:.|.:|    || .....:.|||     .|.:.|..:.|.|
 Worm   617 ESL-----------HSRNSNPEIPNRSFIR----TD-DSVSFFNPST-----TSKVTSFRAQGPP 660

  Fly   562 -EWPAQTSTHSSFSKSAPNLD----KKQQQQNQQQ----VASLTPPPGLGILGGSGGAGGTPATP 617
             ..|.|.:|.....||..|.:    .::.::|:|.    :|.......:..|||
 Worm   661 FPPPPQQNTKPKLLKSVLNSNARHASEEFERNEQDDVVPLAEKNVRKAVTRLGG----------- 714

  Fly   618 LLYPGIPIILTRPNNNNI-GNCKAITTTITTTTTTTTNNNNNNNNSISAN-NNNQLNNISTINSN 680
                      |.|....| ....::....:...:|..:|....::|:|.. :|:.|:.:...:|.
 Worm   715 ----------TMPKGQRIDAYLDSMRRVDSWKESTDADNEGAGSSSLSRTVSNDSLDTLPLPDSM 769

  Fly   681 NNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDD 745
            |::....:.......:.|:            |..:|:..|:.:.|  |||          :.:|.
 Worm   770 NSSTYVKMHPASGENVFLR------------QIRSKLKKRSETPE--LDH----------IDSDT 810

  Fly   746 SSE-TDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPANGSN 809
            :.| |.:..||.|      |.|.|:....:.         |:|... :.||..|....||:..::
 Worm   811 ADETTKSEKSPFG------SLNKSSIKYPIK---------NAPEFS-ENHSRVSPVPVPPSRNAS 859

  Fly   810 SFALPNQLTLPSEDNNTYD-------HAFYRDV------------------IKKMSMASSERVNS 849
            ....|:.....|.|..|.|       ||..|.:                  |:.:.....|..|:
 Worm   860 VSVRPDSKAEDSSDETTKDVGMWGPKHAVTRKIEIVKNDSYPNVEGELKAKIRNLRHVPKEESNT 924

  Fly   850 KSSGDLTMYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEAEDEDAVAAE 914
            .|..||       ||.|.|             ..|.|....||              ||.|...:
 Worm   925 SSQEDL-------PLDATD-------------NTNDSIIVIPR--------------DEKAKVRQ 955

  Fly   915 VDTADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFA 979
            :.|.........:..:.|...|||:|        ::|..|  ...:..|::.|.:|.
 Worm   956 LVTQKVSPLQHHRPFSLQCPNNSTSS--------AISHSE--HADSSETSSLSGVYE-------- 1002

  Fly   980 TYRSASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDV 1026
              ....|.|....:... :..:..|..:|| ..:.|.:..|:.::|:
 Worm  1003 --ERMKPELPRKRSNGD-TKVVPVTWIING-EKEPNGMARTKSLRDI 1045

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	22/135 (16%)
		STKc_MLK	134..389	CDD:270963	94/268 (35%)
abl-1	NP_509778.2	SH3_Abl	119..185	CDD:212784	15/65 (23%)
		SH2_ABL	190..283	CDD:198189	11/92 (12%)
		PTKc_Abl	304..566	CDD:270645	98/276 (36%)
		FABD	1091..1224	CDD:197885