DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and mlk-1

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001300151.1	Gene:	mlk-1 / 178895	WormBaseID:	WBGene00003374	Length:	1059	Species:	Caenorhabditis elegans

Alignment Length:	970	Identity:	227/970 - (23%)
Similarity:	379/970 - (39%)	Gaps:	295/970 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 IPEIPI-PDLEQVETQ---VGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWT 87
            :||:.| .:..||..:   :.....:.|.|:|:||.:|||.|..|.|:.:::.:   :.:.||:.
Worm    49 VPEVRIRSESSQVSRESPPIRASKAFVASYEYEAQKDDELNLPLGAIITLVTVE---TNEDGWYR 110

  Fly    88 GKIGDKVGVFPKDF---VTDEDPL------QLNVSSAIGDIQPHEIEYN--------ELDIKEVI 135
            |::..|||:||.::   ||.:|.|      ::.:..|:..:...:|.:.        ::.||:.:
Worm   111 GELNGKVGLFPSNYAREVTYKDNLVEFKQDEIMLPVAVRTLSDCQIGHGATATVFKMDIKIKKEL 175

  Fly   136 GSGGFCKVHRGYYDGEEVAIKIAHQ----------TGEDDMQRMRDNVLQEAKLFWALKHENIAA 190
            .:|   ::.....|..:.|:|..::          :.::.:::::    :||.|...|.|.||..
Worm   176 QNG---RMGEAVGDQMKAALKRFNRHASNFRADVVSTDEQLEQLK----REANLVNGLSHNNIVR 233

  Fly   191 LRGVCL-NTKLCLVMEYARGGSLNRILA-----GKIPPDVLVNWAIQIARGMNYLHNEAPMSIIH 249
            |.|:|| :....|::|...|.||..:..     ..||..||::||.|:|.||.||..:   ..:|
Worm   234 LLGICLEDPYFGLLLELCEGSSLRNVCRNLNSDAAIPLGVLIDWATQVAEGMEYLTKQ---GYVH 295

  Fly   250 RDLKSSNVLIYEAI--------------------EGNHLQQKTLKITDFGLAREM-YNTQRMSAA 293
            ||||:.|||:.|.:                    ..:.||   |||||||:.|:| .:..|.|.|
Worm   296 RDLKADNVLVKEEVCLCMDEEMFQYAYCLKCGKRPFDKLQ---LKITDFGVTRKMTADANRFSTA 357

  Fly   294 GTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCP 358
            |||||:.||.....|:|:.||||||||:||||:|.|.||:|..|.::|:.:|.....|.|..:||
Worm   358 GTYAWLAPEAFKEGTWSEASDVWSYGVVLWELLTREEPYQGHIPATIAFQIANKGQNLSIGDSCP 422

  Fly   359 ETWGALMKSCWQTDPHKRP-------GFKEILKQLESI----ACSKFTLTPQESFHYMQECWRKE 412
            :.|..||:.||..:|:.||       .||:..|:.:..    |.||..:....|     ||:..:
Worm   423 DRWKKLMQDCWNLEPNFRPKFSTLAISFKQYAKEFKDTHLQRAPSKMAVKELYS-----ECFADK 482

  Fly   413 IAGVLHDLREKEKRFQTI---EEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIEREL 474
            ..      .|.||||..:   ..::..|....:..:.:.|
Worm   483 TK------EEFEKRFHDLYAGSGDINRKNRHSIAPETKAR------------------------- 516

  Fly   475 VMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTW 539
                    :.||.|.||   ..|:.||..:|.::..:|.         ...|:         ||:
Worm   517 --------RLKHHKPKK---ADITGPTEVKHILSVQKDD---------KNFRV---------KTY 552

  Fly   540 GPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGIL 604
            ..|:             :||  ..|......|:.|.|:|:|         ..:::|        :
Worm   553 DQSS-------------TGG--TLPRLNERQSTLSLSSPDL---------FHISNL--------I 585

  Fly   605 GGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNN 669
            .||...|.:.                  :.|....||        ....|.:....:.:.:...:
Worm   586 SGSNTVGHSA------------------HRISRKNAI--------RHKKNQHRMFESPVVSPTMD 624

  Fly   670 QLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKI-YHRARSQEYGLDHPLA 733
            ..|..|||   :|.::.:    ||      :.:.:....|.|::.||: :::..|:|   ||
Worm   625 DSNTFSTI---DNADEVD----PN------HSKESKKGGTLSRAWAKLPWNKRDSKE---DH--- 670

  Fly   734 YQPPPLYLVTDDSSETDTV---ASPTGCFHFLKSGNSSAASGAVHLHRFGG-SLGNSPAVG---- 790
                      |:.:...::   :|.|...:.|.:|.::..:.|..|...|. |...|.|.|
Worm   671 ----------DERAVAGSISSRSSSTTSSNRLITGQTTRGASAAGLLEIGARSRAQSTADGWEDP 725

  Fly   791 --RKKHSLDSSSHHP--PANGSNSFA---------LPNQL-----------TLPSEDNNTYDHAF 831
              .|||.:..|...|  ..|.:..:.         .|.||           |:|:..|:.
Worm   726 NTTKKHKVSPSDKRPVKTTNQTERYVKDLEKDTPLRPAQLPPTHRKSALDQTIPASPNSP----- 785

  Fly   832 YRDVIKKM--SMASSERVNSKSSGDLTMYNSSTPLTARDCDDA--EEAFEGGRFQRNFSG 887
              |.|...  ...||.|..:.||.|           ...|.||  ..::..|...:|..|
Worm   786 --DSINNFHPMPLSSRRTTANSSSD-----------GAPCYDALVSHSYGAGHGHKNHFG 832

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	20/59 (34%)
		TyrKc	129..386	CDD:197581	101/300 (34%)
		STKc_MLK	134..389	CDD:270963	99/298 (33%)
mlk-1	NP_001300151.1	SH3	75..124	CDD:302595	19/51 (37%)
		STYKc	153..450	CDD:214568	99/309 (32%)
		PKc_like	156..446	CDD:304357	99/302 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159046
Domainoid	1	1.000	164	1.000	Domainoid score	I2387
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		oto19411
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.740