DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and zak-1

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001367790.1	Gene:	zak-1 / 175954	WormBaseID:	WBGene00006971	Length:	745	Species:	Caenorhabditis elegans

Alignment Length:	856	Identity:	191/856 - (22%)
Similarity:	316/856 - (36%)	Gaps:	278/856 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 EIEYNELDIKEVIGSGGFCKVHRGYY---DGEE--VAIKIAHQTGEDDMQRMRDNVLQ-EAKLFW 181
            :|:.:::.:.:.||.|.|..|..|.:   ||.:  :|:|             :..||: ||::..
Worm    25 DIQRDDIQVGDHIGVGTFGAVFSGNWTLPDGSQRTIALK-------------KVFVLEKEAEILS 76

  Fly   182 ALKHENIAALRGVCLNT--KLCLVMEYARGGSLNRIL-----------AGKIPPDVLVNWAIQIA 233
            .::|:||....|:|..|  ...:|.|||..|||...:           :|....||:|.||.|||
Worm    77 KIRHKNIIQFYGICKATGNDFFIVTEYAEKGSLYDFIHSEESQSFASSSGGNSFDVVVKWASQIA 141

  Fly   234 RGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTL--KITDFGLAREM-YNTQRMSAAGT 295
            .|:.|||.:|..:||||||||.||::          .|.|  ||.|||.:::: ::....|..||
Worm   142 SGIQYLHYDAVDTIIHRDLKSKNVVL----------DKNLVCKICDFGTSKDLTHSCTAPSWGGT 196

  Fly   296 YAWMPPEVISVST-YSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPE 359
            .|||.||:|..|. .:..:|||||||:|||:::.|.|||.:....:...:..:.:||.||.:||.
Worm   197 AAWMSPEMILQSEGLTTATDVWSYGVVLWEILSKEVPYKDYSEFRIFTMITQSGITLAIPPSCPA 261

  Fly   360 TWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKE 424
            ....||.:||:..|..|...::|..:|..:|.::..:...|.|..::: |:.||       .::|
Worm   262 PLKQLMSNCWKMTPKDRANMRQIQGELNRLAGNQKVMDECEKFMGLED-WKTEI-------EKQE 318

  Fly   425 KRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHKKG 489
            |..:.:.::|..:.||              |:|||:.|::|.:|  |:.::.....|.:..|:..
Worm   319 KNVEKMRKDLEKRREQ--------------LEIREKALKQRMKV--EQAVLDSARHPPEDVHQWS 367

  Fly   490 KKNKPLQISLPTG----------------FRHTITAVR------DKAEQPGSPSFSGLRIV---- 528
            :.:....:....|                ||:.||..|      :..|..|.... |.||.
Worm   368 EHHTSHWVETVLGRVANDKKFLDRVNAAVFRNRITGARLLGMTQNDLEHLGVHKV-GSRIELMKM 431

  Fly   529 --ALTDGHKGKTWGPSTMHQRER---SLLPSQLSGGQ---------------------------- 560
              .|.|..|.....| |:.|.:|   :|...:.:.||
Worm   432 IRKLADTQKALHNFP-TLEQAKRIEMTLKTEKEAAGQLANDVDIVIIVGMYVRKMNATRRKFKFY 495

  Fly   561 --PEW------PAQT-STHSS-------FSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSGG 609
              .:|      ||:: |.|:|       ||.    ||:..::...:...|:           |.|
Worm   496 ADSDWIDDTDIPAKSKSKHASSLIKTVCFSV----LDENTKKPINEPACSI-----------SSG 545

  Fly   610 AGGTP---------------ATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNN 659
            ....|               ...:.|..   |:|:|.|..:  .|.:|:.
Worm   546 MTTNPDWITVDTEDDVKIRVIVSVYYAD---IVTQPRNTEV--IKVVTSL--------------- 590

  Fly   660 NNSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQ 724
                                    .::.:..:.:..:.|:...::::.||.|...|.:||.....
Worm   591 ------------------------EESKILEERHVHLRLRRSSSSASISTPSPVIAPVYHPFGHL 631

  Fly   725 EYGLDHPLAYQPPPLYLVTDDSSETDTVASP--TGCFHFLKSGNSSAASGAVHLHRFGGSLGNSP 787
            ..|..|                    |.:||  .|.:|                         ..
Worm   632 NNGFHH--------------------TTSSPQLRGFWH-------------------------RK 651

  Fly   788 AVGRKKHSLDSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSS 852
            ..|..:|.|..         :...:|..||..||.|....|......|.|......:...||:.:
Worm   652 QTGMNRHGLTE---------TELSSLQEQLRTPSPDKKVVDENVIIHVPKLTRRRRTTTTNSEDT 707

  Fly   853 GDLTMYNSSTP 863
             :.:..|:.||
Worm   708 -EKSDTNNKTP 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	95/279 (34%)
		STKc_MLK	134..389	CDD:270963	96/277 (35%)
zak-1	NP_001367790.1	PKc_like	38..291	CDD:419665	95/275 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810