DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and sel-15

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001366799.1	Gene:	sel-15 / 175225	WormBaseID:	WBGene00016030	Length:	847	Species:	Caenorhabditis elegans

Alignment Length:	388	Identity:	111/388 - (28%)
Similarity:	167/388 - (43%)	Gaps:	77/388 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LEQVETQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLS--TDSEVSGDV-------------- 83
            |:..:|.|    :|.....:||            ||.:|.  ....|.|||
Worm   433 LDDQQTPV----IWAYERGHDA------------IVALLKHYAARTVEGDVCSEYSSGESSYTPL 481

  Fly    84 ----GWWTGKIGDKVGVFPKDFVTDEDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVH 144
                |..|....||.           |.|||.  ||:.  .|..:...|::.:|.||||.|.||:
Worm   482 PSPMGRLTSLTRDKA-----------DLLQLR--SALP--APFHLCLAEIEFQESIGSGSFGKVY 531

  Fly   145 RGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLN--TKLCLVMEYA 207
            :|.|.|:.||:| .::......:...|.:.:|..:...|.|.|:.|..|..|:  ::..::.|:.
Worm   532 KGTYRGKLVAVK-RYRAMAFGCKSETDMLCREVSILSRLAHPNVVAFVGTSLDDPSQFAIITEFV 595

  Fly   208 RGGSLNRILAGK---IPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQ 269
            ..|||.|:|..:   :.|...:..::.:||||.|||..|...:|||||.|.|:||       |..
Worm   596 ENGSLFRLLHEEKRVMDPAFRLRISLDVARGMRYLHESAAKPVIHRDLNSHNILI-------HAD 653

  Fly   270 QKTLKITDFGLAREMYNTQR-----MSAAGTYAWMPPEVISVS-TYSKFSDVWSYGVLLWELITG 328
            .::: :.|||.:|  :..||     ....|...||.|||.|.| .|.:..||:|:.:::||:.|.
Worm   654 GRSV-VADFGESR--FVCQREDENLTKQPGNLRWMAPEVFSQSGKYDRKVDVFSFALVIWEIHTA 715

  Fly   329 ETPYKGFDPLSVAYGVAV--NTLTLPIPKTC--PETWGALMKSCWQTDPHKRPGFKEILKQLE 387
            |.|:....|.:.|..:..  ...|||...|.  |....:|:...|..:...||.|.||:..||
Worm   716 ELPFSHLKPAAAAAEMTYKRGRPTLPNQPTAQFPAHILSLIPQAWHPESSSRPDFVEIVALLE 778

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	14/76 (18%)
		TyrKc	129..386	CDD:197581	84/271 (31%)
		STKc_MLK	134..389	CDD:270963	85/269 (32%)
sel-15	NP_001366799.1	ANKYR	3..217	CDD:223738
		ANK repeat	115..147	CDD:293786
		PHA03095	128..>388	CDD:222980
		ANK repeat	153..180	CDD:293786
		ANK repeat	182..213	CDD:293786
		ANK repeat	215..246	CDD:293786
		ANK repeat	285..318	CDD:293786
		ANK repeat	320..353	CDD:293786
		ANKYR	<323..458	CDD:223738	9/40 (23%)
		ANK repeat	355..380	CDD:293786
		PKc_TNNI3K	522..780	CDD:270966	85/268 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910