Protein Alignment slpr and src-2

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_493502.1
• Gene: src-2 / 173296
• WormBaseID: WBGene00005078
• Length: 507
• Species: Caenorhabditis elegans
• Alignment Length: 496
• Identity: 122/496 - (24%)
• Similarity: 194/496 - (39%)
• Gaps: 147/496 - (29%)

  Fly    24 HPQIPEI-PIPDLEQVET-----QVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGD 82
            ||:||.| ||.......|     .:...:.:.||:.|||:.:|:|:.::.:|:.:|   ::..||
 Worm    32 HPRIPSIGPIAASSSGNTIDKNQNISQSANFVALFQYDARTDDDLSFKKDDILEIL---NDTQGD 93

  Fly    83 VGWWTG--KIGDKVGVFPKDFVTDEDPLQ---------------------LNVSSAI----GDIQ 120
              ||..  |...:.|..|.::|..|..::                     ||...|.    .:.:
 Worm    94 --WWFARHKATGRTGYIPSNYVAREKSIESQPWYFGKMRRIDAEKCLLHTLNEHGAFLVRDSESR 156

  Fly   121 PHEIEYN---------------------------------------------------------- 127
            .|::..:
 Worm   157 QHDLSLSVRENDSVKHYRIRQLDHGGYFIARRRPFATLHDLIAHYQREADGLCVNLGAPCAKSEA 221

  Fly   128 ------------ELDIKEV-----IGSGGFCKVHRGYYD-GEEVAIKIAHQTGEDDMQRMRDNVL 174
                        |:|.:.|     ||:|.|.:|..|.:: ...||:| ..:.|..|    ..:.|
 Worm   222 PQTTTFTYDDQWEVDRRSVRLIRQIGAGQFGEVWEGRWNVNVPVAVK-KLKAGTAD----PTDFL 281

  Fly   175 QEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAGK-----IPPDVLVNWAIQIAR 234
            .||::...|:|..:.:|..||...:..|::......:|...|..:     :|.  ||..:.|:|.
 Worm   282 AEAQIMKKLRHPKLLSLYAVCTRDEPILIVTELMQENLLTFLQRRGRQCQMPQ--LVEISAQVAA 344

  Fly   235 GMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAR----EMYNTQRMSAAGT 295
            ||.||..   |:.|||||.:.|:||..::        ::||.||||||    |.....|..|...
 Worm   345 GMAYLEE---MNFIHRDLAARNILINNSL--------SVKIADFGLARILMKENEYEARTGARFP 398

  Fly   296 YAWMPPEVISVSTYSKFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPE 359
            ..|..||..:.:.::..|||||:|:||.|::| |..||.|.....|...|... ..:|.|..||.
 Worm   399 IKWTAPEAANYNRFTTKSDVWSFGILLTEIVTFGRLPYPGMTNAEVLQQVDAG-YRMPCPAGCPV 462

  Fly   360 TWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQE 400
            |...:|:.||::||.|||.|:.:..:||.:    |.|...|
 Worm   463 TLYDIMQQCWRSDPDKRPTFETLQWKLEDL----FNLDSSE 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	17/58 (29%)
		STKc_MLK	134..389	CDD:270963	87/270 (32%)
src-2	NP_493502.1	SH3_Src_like	61..112	CDD:212779	16/55 (29%)
		SH2_Src_Src42	120..215	CDD:198233	4/94 (4%)
		PTKc_Frk_like	231..496	CDD:270653	90/287 (31%)