DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and lrk-1

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_492839.4	Gene:	lrk-1 / 172995	WormBaseID:	WBGene00003068	Length:	2393	Species:	Caenorhabditis elegans

Alignment Length:	407	Identity:	107/407 - (26%)
Similarity:	169/407 - (41%)	Gaps:	88/407 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 GEIVVVLST---DSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPL-------------------Q 109
            ||:.:..|:   .|..:||:....|      ||. ..||.:|..|                   :
Worm  1616 GELPITSSSHMKGSRTTGDISKCRG------GVV-HCFVIEECMLAGREYNWVECPSHGGLHMRE 1673

  Fly   110 LNVSSAIGDIQ-PHEIEYNELDIKEVIGSGGFCKVHRGYY---DGE--EVAIKI----------- 157
            |...:...||: ...|..::|....::|.|.|..|.|...   :||  |||.|:
Worm  1674 LAPDTVFADIENALTIHPDQLKRSRMLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGR 1738

  Fly   158 -----AHQTGEDDMQRMRDNV----------LQEAKLFWALKHENIAALRGVCLNTKLCLVMEYA 207
                 |::...|..:  ||::          .||..|...:||.|:..|.||| ...|.||:|.|
Worm  1739 PSALAAYKAAADKWK--RDSMEFACRAYCTSRQELSLLSRMKHPNVIGLVGVC-TFPLSLVVELA 1800

  Fly   208 RGGSLNRIL-----AG-KIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGN 266
            ..|:||::|     || |:...|:...|:|:||.:.|||:   ..||:|||||.|||.:......
Worm  1801 PLGALNQLLGSHRKAGTKLSLGVIKESAVQVARALEYLHS---AHIIYRDLKSENVLGWRFPAPF 1862

  Fly   267 HLQQKT-LKITDFGLAREMYNTQRMSA-AGTYAWMPPEVISVS---TYSKFSDVWSYGVLLWELI 326
            ..|... ||:.|:|::|.:..:..... .||..:|.||::..:   .|::..|.:|:|:.|:||:
Worm  1863 SPQTDVLLKLGDYGISRSVLPSGGAKGFGGTEGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELL 1927

  Fly   327 TGETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIAC 391
            |.:.|::..:.:..........:.||.....|.....|:..||...|..||...:::
Worm  1928 TLKFPFESEEHVKERMLDGARPVLLPHELLLPTPMLDLLVHCWSAHPESRPSSSQLV-------- 1984

  Fly   392 SKFTLTPQESFHYMQEC 408
             .|...| |..|.:..|
Worm  1985 -GFCAAP-EFTHLLDVC 1999

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	11/39 (28%)
		TyrKc	129..386	CDD:197581	85/298 (29%)
		STKc_MLK	134..389	CDD:270963	84/296 (28%)
lrk-1	NP_492839.4	Ank_2	29..121	CDD:289560
		ANK	51..218	CDD:238125
		ANK repeat	56..88	CDD:293786
		ANK repeat	90..121	CDD:293786
		ANK	192..337	CDD:238125
		ANK repeat	197..228	CDD:293786
		Ank_2	202..286	CDD:289560
		ANK repeat	230..262	CDD:293786
		Ank_2	269..390	CDD:289560
		ANK	312..456	CDD:238125
		ANK repeat	361..390	CDD:293786
		Ank_2	366..472	CDD:289560
		ANK repeat	398..432	CDD:293786
		LRR_RI	<512..>639	CDD:238064
		leucine-rich repeat	534..555	CDD:275380
		LRR_8	554..615	CDD:290566
		leucine-rich repeat	556..580	CDD:275380
		leucine-rich repeat	581..604	CDD:275380
		leucine-rich repeat	605..627	CDD:275380
		leucine-rich repeat	628..654	CDD:275380
		leucine-rich repeat	655..684	CDD:275380
		leucine-rich repeat	687..718	CDD:275380
		LRR_8	718..776	CDD:290566
		leucine-rich repeat	719..742	CDD:275380
		leucine-rich repeat	743..765	CDD:275380
		leucine-rich repeat	803..856	CDD:275380
		LRR_8	857..915	CDD:290566
		leucine-rich repeat	857..883	CDD:275380
		leucine-rich repeat	884..906	CDD:275380
		leucine-rich repeat	907..931	CDD:275380
		P-loop_NTPase	977..1160	CDD:304359
		COR	<1239..>1336	CDD:292713
		S_TKc	1698..1983	CDD:214567	84/290 (29%)
		PKc_like	1699..1990	CDD:304357	85/305 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900