Protein Alignment slpr and Fgfr1

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: NP_034336.2
• Gene: Fgfr1 / 14182
• MGIID: 95522
• Length: 822
• Species: Mus musculus
• Alignment Length: 376
• Identity: 108/376 - (28%)
• Similarity: 167/376 - (44%)
• Gaps: 65/376 - (17%)

  Fly    62 LTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVTDEDPLQLNVSSAIGDIQPH-EIE 125
            :.|||   .|.:|.||..|.:.|        .:.|.|....:...|:...||.......|. |:.
Mouse   421 IPLRR---QVTVSADSSASMNSG--------VLLVRPSRLSSSGTPMLAGVSEYELPEDPRWELP 474

  Fly   126 YNELDIKEVIGSGGFCKVHRGYYDG---------EEVAIKIAHQTGEDDMQRMRDNVLQEAKLFW 181
            .:.|.:.:.:|.|.|.:|......|         .:||:|:..   .|..::...:::.|.::..
Mouse   475 RDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLK---SDATEKDLSDLISEMEMMK 536

  Fly   182 AL-KHENIAALRGVCL-NTKLCLVMEYARGGSLNRILAGKIPPDV------------------LV 226
            .: ||:||..|.|.|. :..|.:::|||..|:|...|..:.||.:                  ||
Mouse   537 MIGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLV 601

  Fly   227 NWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREM----YNT 287
            :.|.|:||||.||   |....|||||.:.|||:.|        ...:||.||||||::    |..
Mouse   602 SCAYQVARGMEYL---ASKKCIHRDLAARNVLVTE--------DNVMKIADFGLARDIHHIDYYK 655

  Fly   288 QRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTL 351
            :..:......||.||.:....|:..|||||:||||||:.| |.:||.|. |:...:.:......:
Mouse   656 KTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGV-PVEELFKLLKEGHRM 719

  Fly   352 PIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESF 402
            ..|..|......:|:.||...|.:||.||::::.|:.|.    .||..:.:
Mouse   720 DKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRIV----ALTSNQEY 766

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	11/41 (27%)
		STKc_MLK	134..389	CDD:270963	88/288 (31%)
Fgfr1	NP_034336.2	IgI_1_FGFR	25..118	CDD:409362
		Ig strand A	25..28	CDD:409362
		Ig strand A'	40..46	CDD:409362
		Ig strand B	49..59	CDD:409362
		Ig strand C	63..68	CDD:409362
		Ig strand C'	71..73	CDD:409362
		Ig strand D	78..82	CDD:409362
		Ig strand E	85..90	CDD:409362
		Ig strand F	96..105	CDD:409362
		Ig strand G	108..118	CDD:409362
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..162
		IgI_2_FGFR	153..247	CDD:409443
		Ig strand A	153..156	CDD:409443
		Heparin-binding	160..177
		Ig strand A'	164..169	CDD:409443
		Ig strand B	173..181	CDD:409443
		Ig strand C	187..192	CDD:409443
		Ig strand C'	195..197	CDD:409443
		Ig strand D	206..209	CDD:409443
		Ig strand E	213..218	CDD:409443
		Ig strand F	227..234	CDD:409443
		Ig strand G	237..247	CDD:409443
		Ig	255..359	CDD:472250
		Ig strand B	273..277	CDD:409353
		Ig strand C	286..290	CDD:409353
		Ig strand E	324..328	CDD:409353
		Ig strand F	338..343	CDD:409353
		Ig strand G	351..354	CDD:409353
		PTKc_FGFR1	464..765	CDD:270678	94/319 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	782..822