Protein Alignment slpr and Abl

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_061501128.1
• Gene: Abl / 1275815
• VectorBaseID: AGAMI1_014695
• Length: 1721
• Species: Anopheles gambiae
• Alignment Length: 1405
• Identity: 294/1405 - (20%)
• Similarity: 474/1405 - (33%)
• Gaps: 489/1405 - (34%)

  Fly    44 DGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDS--------EVSGDVGWWTGKIGDKVGVFPKD 100
            |..|:.||||:.|.||::|:||:||.|.:||.:.        ..||.|||           .|.:
Mosquito   120 DPQLFVALYDFKAGGENQLSLRKGEQVRILSYNKSGEWCEAHSDSGHVGW-----------VPSN 173

  Fly   101 FVT-------------------------------------DEDPLQLNVS--------------- 113
            :||                                     :..|.|.::|
Mosquito   174 YVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYDGRVYHYRISED 238

  Fly   114 -----------------------SAIGD------------------------IQPHEIEYNELDI 131
                                   ||:.:                        .:|.|.|....||
Mosquito   239 SDGKVYVTADAKFNTLAELVHHHSALHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDI 303

  Fly   132 --KEVIGSGGFCKVHRGYYD--GEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALR 192
              |..:|.|.:.:|:...:.  |..||:|    |.::|...::| .|:||.:...:||.|:..|.
Mosquito   304 VMKHKLGGGQYGEVYEAVWKRYGNTVAVK----TLKEDTMALKD-FLEEAAIMKEMKHPNLVQLI 363

  Fly   193 GVCL-NTKLCLVMEYARGGSLNRIL--AGKIPPD--VLVNWAIQIARGMNYLHNEAPMSIIHRDL 252
            |||. .....::.|:...|:|...|  ||:...|  .|:..|.|||.||:||.:.   :.|||||
Mosquito   364 GVCTREPPFYIITEFMSHGNLLDFLRTAGRETLDAVALLYMATQIASGMSYLESR---NFIHRDL 425

  Fly   253 KSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGT---YAWMPPEVISVSTYSKFSD 314
            .:.|.|:.:    |:|    :|:.||||||.|.:....:.||.   ..|..||.::.:.:|..||
Mosquito   426 AARNCLVGD----NNL----VKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSD 482

  Fly   315 VWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPG 378
            ||::||||||:.| |.:||.|.| |:..:....:...:..|..||.....||:.|||.:...||.
Mosquito   483 VWAFGVLLWEIATYGMSPYPGID-LTDVFHKLESGYRMERPPGCPPEVYDLMRKCWQWNAQDRPT 546

  Fly   379 FKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLR 443
            ||.|...||               |..||....|..         ||:.|.:     ......|.
Mosquito   547 FKSIHHDLE---------------HMFQESSITEAV---------EKQLQGV-----GVMPMQLT 582

  Fly   444 VQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTIT 508
            .|..::....:.:.::|.|::::         :|.|.||:.:.   ::.:|:|      ....||
Mosquito   583 PQMSKKPHMGMQQQQQQQLQQQQ---------LLPPPPSQTQQ---QQQQPVQ------HEPAIT 629

  Fly   509 AVRDKAEQPGS---------PSFSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSG------ 558
            .:.|...  ||         ||.:|:: :..|...:||| .|:.  .:..|||.|....
Mosquito   630 PISDSGS--GSKFSTFGNKQPSTAGVQ-MRRTTNKRGKT-APAP--PKRTSLLSSSRDSTYRDDD 688

  Fly   559 ----GQPEWPA--------QTSTHSS---------FSKSAPNL-DKKQQQQNQQQVASLTP---- 597
                |:.|..|        ::|:.||         ||:...|| ::....:|:|  ..:||
Mosquito   689 NCKLGEGEQNANGTTIPITKSSSCSSFLIDKLFRGFSRDMANLMNRATDSENEQ--TEVTPDTDT 751

  Fly   598 --PPGLG--------------ILGGSG--------------------GAGGTPATPLLYPGIPII 626
              |..:|              |:|..|                    |.||.|.||:|..|.|.|
Mosquito   752 DNPEPVGFQKTPQQSSFKRAPIMGNRGLETRGSKRLPQQARRDQLPPGPGGQPCTPVLGTGQPPI 816

  Fly   627 L----------------TRPNNNNIGNCKAITTTITTTTTTTTNNNNN--NNNSISANNNNQLNN 673
            :                |.|.:..||   |...::..:..|.......  ....:..:...|..:
Mosquito   817 VGALEVQNVKKAINRYGTLPKDARIG---AYLESLRQSDGTVIQQGQPPVQQQQLPQHQQPQQQH 878

  Fly   674 I-------STINSNNNNNQTNLTSQP------------NTIIVLQNG----------RNNSNSST 709
            :       :.:....|.|.. |.|:|            |:|:..:|.          |:||:|..
Mosquito   879 VVGPPPGAAPMQMGMNPNMA-LVSEPPPPPMAAANAISNSILAQRNAAAIKAQPQMIRSNSSSGV 942

  Fly   710 TSQSPA-----KIY-HRARSQ-----------EYGLDHP----------LAYQPPPLYLVTDDSS 747
            |..:.|     |:. ||..:.           ..|.:.|          |.:.|||:.| .....
Mosquito   943 TMSNSATASLSKLQRHRTTTDGSMMTFSSFRGSVGNNSPKRAVQPTLADLEFPPPPVDL-PPPPE 1006

  Fly   748 ETDTVASPTGCFHFLKSGNSSAASGAVHLH-------------------RFGGSLGNSPAVGRKK 793
            |.|......|       |.|..:.|.:...                   |||.||       ||:
Mosquito  1007 EFDMPLDQRG-------GGSGGSGGMLEKSIAPSNDVRNTEPSVEEASTRFGVSL-------RKR 1057

  Fly   794 H-SLDS-SSHHPPANGS-NSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKS---S 852
            . |.|| ||...||:.. |:...|:.|.:|....            .|...|..:||.:..   .
Mosquito  1058 EPSTDSCSSLGSPADAMINTVGDPSSLPIPPPPP------------AKDLKADPKRVTNVPKCLQ 1110

  Fly   853 GDLTMYNSSTPLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEGEAEDEDAVAAEVDT 917
            ||:.                    .|.|......|:..|.....:   |..|::......:.:.|
Mosquito  1111 GDVV--------------------GGKRTAGPLHGTSDPASQLVS---ELAESKHLPKAPSPLTT 1152

  Fly   918 ADADADDECQVPASQMRQNSTTSRKSSVTFQSVSFEEPDFVATPRTTARSDLYTSSASISFATYR 982
            |......:.|.|.|..:.:..:|.:..|:.                        |.::|..:|..
Mosquito  1153 AQEPQHHQQQQPISHYKSSDVSSLRKPVSM------------------------SKSTILPSTNA 1193

  Fly   983 SASPSLSSSSTTASASPSIASTEAVNGYHMQENSILNTRRMQDVQPHP------DVIKLRAQEQR 1041
            :|:.:.|:::..||..|.       ..:..|...: :|.:....||..      .:|..:::.::
Mosquito  1194 AANDNYSAATNAASGVPQ-------PPFKAQLKKV-DTAKRAPAQPAKKEESTGGIIDFKSRLRK 1250

  Fly  1042 QQTKNQKKQRPKHITKSKSVEAPVEGQHHEHDDHNDPQHQHHSAGSSKIRALFNLFTRSRKKYSK 1106
            ....|.:..........:||:.|..         |...:..|.||.:.::::.|      ..::.
Mosquito  1251 VDQNNTEVSSNGGSGGGESVDPPTS---------NVDNNNKHQAGGNSLQSIHN------NNFNT 1300

  Fly  1107 LAEHNMVGGPEFCAIDPYQTDLAMGGSSRSLKRKGKKPQT 1146
            .|..|...|.   .::......:...|.....|..||.:|
Mosquito  1301 TASSNNSNGN---ILNNNDNSASSSSSENENHRSAKKGET 1337

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	24/101 (24%)
		STKc_MLK	134..389	CDD:270963	91/265 (34%)
Abl	XP_061501128.1	None