DRSC/TRiP Functional Genomics Resources

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Protein Alignment slpr and Abl2

DIOPT Version :10

Sequence 1:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_033725.2 Gene:Abl2 / 11352 MGIID:87860 Length:1182 Species:Mus musculus


Alignment Length:1040 Identity:232/1040 - (22%)
Similarity:369/1040 - (35%) Gaps:352/1040 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly    44 DGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWT---GKIGDKVGVFPKDFVT-- 103
            |.:|:.||||:.|.|::.|::.:||.:.||..:..     |.|:   .|.|.  |..|.:::|  
Mouse   108 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQN-----GEWSEVRSKNGQ--GWVPSNYITPV 165

  Fly   104 -----------------------------------DEDPLQLNVS-------------------- 113
                                               :..|.||::|                    
Mouse   166 NSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRVYHYRINTTTDSKV 230

  Fly   114 --------SAIGDIQPH----------------------------------EIEYNELDIKEVIG 136
                    |.:.::..|                                  |:|..::.:|..:|
Mouse   231 YVTAESRFSTLAELVHHHSTVADGLVTTLHYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLG 295

  Fly   137 SGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVC-LNTKL 200
            .|.:.:|:.|.:  ::.::.:|.:|.::|...: :..|:||.:...:||.|:..|.||| |....
Mouse   296 GGQYGEVYVGVW--KKYSLTVAVKTLKEDTMEV-EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPF 357

  Fly   201 CLVMEYARGGSLNRIL----AGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYE 261
            .:|.||...|:|...|    ..::...||:..|.||:..|.||..:   :.|||||.:.|.|:.|
Mouse   358 YIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGE 419

  Fly   262 AIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGT---YAWMPPEVISVSTYSKFSDVWSYGVLLW 323
                ||:    :|:.||||:|.|......:.||.   ..|..||.::.:|:|..||||::|||||
Mouse   420 ----NHV----VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLW 476

  Fly   324 ELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLE 387
            |:.| |.:||.|.| ||..|.:......:..|:.||.....||::||:..|..||.|.|..:..|
Mouse   477 EIATYGMSPYPGID-LSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540

  Fly   388 SIACSKFTLTPQESFH-------YMQECWR----KEIAGVLHDLREKEKRFQTIEEELRNKE--- 438
            ::            ||       ..:|..|    ..:...|..|.....:.:|:.::..|||   
Mouse   541 TM------------FHDSSISEEVAEELGRTASSSSVVPYLPRLPLLPSKTRTLRKQGENKENLD 593

  Fly   439 ------EQLL-------------------RVQNEQREK--ANLLKIREQNLRERERVLIERELVM 476
                  |.|.                   .:..:||:|  ::||:..::....|:|         
Mouse   594 GGLDAAESLASSSAPAGFIRSTQASSGSPALPRKQRDKSPSSLLEDAKETCFTRDR--------- 649

  Fly   477 LQPVPSKRKHKKG--------KKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDG 533
                       ||        |:|.|......:.||........|.|..|  :||.:..:...||
Mouse   650 -----------KGGFFSSFMKKRNAPTPPKRSSSFREMENQPHKKYELTG--NFSPVASLQHADG 701

  Fly   534 HKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPP 598
            .   :..||   |:|.:|:|::..||            ||:           |:|      |...
Mouse   702 F---SVAPS---QQEPNLVPAKCYGG------------SFA-----------QRN------LCAD 731

  Fly   599 PGLGILGGSGGAGGTPATPLLYPGI-----PIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNN 658
            ...|..||||.|||.      :.||     |.::.:......|...|      :..|:.....:|
Mouse   732 DDSGGGGGSGTAGGG------WSGITGFFTPRLIKKTLGLRAGKPTA------SDDTSKPFPRSN 784

  Fly   659 NNNSISANNNNQLNNISTINSNNNNNQTNL------TSQPNTIIVLQNGRNNS---NSSTTSQSP 714
            :.:|:|:....|.....|:..|...::..|      :|||...:    .|.|.   ..|....:|
Mouse   785 STSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVSTSSQPEENV----DRANDMLPKKSEEGAAP 845

  Fly   715 AKIYHRARSQEYGLDHPLAYQPPPLYLVTDDSSE----TDTVASPTGCFHFLKSGNSSAASGAVH 775
            |:...:|:....|........|.|  .:|:..|.    ....|:|.|     |..|.....|...
Mouse   846 ARERPKAKLLPRGATALPLRAPDP--AITESDSPGVGVAGVAAAPKG-----KERNGGTRLGVAG 903

  Fly   776 LHRFGGSLG-NSPAVGRKKHSLDSSSH-------------HPPAN----GSNSFALPNQLTLPSE 822
            :...|..|| :|||   |..::..::|             |.||:    |::|..  |:..|.||
Mouse   904 VPEDGEQLGWSSPA---KAVAVLPTTHNHKVPVLISPTLKHTPADVQLIGTDSQG--NKFKLLSE 963

  Fly   823 DNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLTMYNSSTPLTA-------------RDCDDAEE 874
            ...|                        ||||........|..|             ..|.|.||
Mouse   964 HQVT------------------------SSGDKDRPRRVKPKCAPPPPPVMRLLQHPSTCSDPEE 1004

  Fly   875  874
            Mouse  1005  1004

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809 19/96 (20%)
STKc_MLK 134..389 CDD:270963 88/263 (33%)
Abl2NP_033725.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..42
CAP 2..106
SH3_Abl 111..164 CDD:212784 18/59 (31%)
SH2_ABL 169..262 CDD:198189 6/92 (7%)
PTKc_Abl 281..543 CDD:270645 91/288 (32%)
Kinase activation loop. /evidence=ECO:0000250 427..451 8/23 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 612..642 5/29 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..674 3/18 (17%)
Nuclear localization signal. /evidence=ECO:0000255 659..661 0/1 (0%)
F-actin-binding 695..930 64/295 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 765..796 6/36 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 809..858 10/52 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 964..1059 11/65 (17%)
F-actin-binding 1020..1182
FABD 1063..1182 CDD:197885
Blue background indicates that the domain is not in the aligned region.

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