DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and Abl1

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001106174.1	Gene:	Abl1 / 11350	MGIID:	87859	Length:	1142	Species:	Mus musculus

Alignment Length:	1063	Identity:	227/1063 - (21%)
Similarity:	377/1063 - (35%)	Gaps:	353/1063 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 DGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKDFVT----- 103
            |.:|:.||||:.|.|::.|::.:||.:.||..:.  :|:  |...:..:..|..|.:::|
Mouse    81 DPNLFVALYDFVASGDNTLSITKGEKLRVLGYNH--NGE--WCEAQTKNGQGWVPSNYITPVNSL 141

  Fly   104 --------------------------------DEDPLQLNVS----------------------- 113
                                            :..|.|.::|
Mouse   142 EKHSWYHGPVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVS 206

  Fly   114 ---------------SAIGD--------------------IQPH----EIEYNELDIKEVIGSGG 139
                           |.:.|                    :.|:    |:|..::.:|..:|.|.
Mouse   207 SESRFNTLAELVHHHSTVADGLITTLHYPAPKRNKPTIYGVSPNYDKWEMERTDITMKHKLGGGQ 271

  Fly   140 FCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLV 203
            :.:|:.|.:  ::.::.:|.:|.::|...: :..|:||.:...:||.|:..|.|||. .....::
Mouse   272 YGEVYEGVW--KKYSLTVAVKTLKEDTMEV-EEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYII 333

  Fly   204 MEYARGGSL-------NRILAGKIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYE 261
            .|:...|:|       ||   .::...||:..|.||:..|.||..:   :.|||||.:.|.|:.|
Mouse   334 TEFMTYGNLLDYLRECNR---QEVSAVVLLYMATQISSAMEYLEKK---NFIHRDLAARNCLVGE 392

  Fly   262 AIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGT---YAWMPPEVISVSTYSKFSDVWSYGVLLW 323
                |||    :|:.||||:|.|......:.||.   ..|..||.::.:.:|..||||::|||||
Mouse   393 ----NHL----VKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLW 449

  Fly   324 ELIT-GETPYKGFDPLSVAYGVAVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLE 387
            |:.| |.:||.|.| ||..|.:......:..|:.|||....||::|||.:|..||.|.||.:..|
Mouse   450 EIATYGMSPYPGID-LSQVYELLEKDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFE 513

  Fly   388 SIACSKFTLTPQESFHYMQECWRKEI--------AGVLHDLREKEKRFQTIEEELRNKE----EQ 440
            ::.        |||  .:.:...||:        ||.:....|...:.:|.......|:    .:
Mouse   514 TMF--------QES--SISDEVEKELGKRGTRGGAGSMLQAPELPTKTRTCRRAAEQKDAPDTPE 568

  Fly   441 LLRVQ--------NEQREKANLLKIREQ-----NLRERERVLIERELVMLQPVPSKRKH------ 486
            ||..:        :.:...:.||..:|:     :|.|.||:|           |..||.
Mouse   569 LLHTKGLGESDALDSEPAVSPLLPRKERGPPDGSLNEDERLL-----------PRDRKTNLFSAL 622

  Fly   487 -KKGKKNKPLQISLPTGFRH-----------------------TITAVRDKAE------------ 515
             ||.||..|......:.||.                       .:|:  |.||
Mouse   623 IKKKKKMAPTPPKRSSSFREMDGQPDRRGASEDDSRELCNGPPALTS--DAAEPTKSPKASNGAG 685

  Fly   516 -------QPGSPSF------------SGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGG-- 559
                   :||:..|            :|.|:.|..:..     |.|:..:..||...|.:..|
Mouse   686 VPNGAFREPGNSGFRSPHMWKKSSTLTGSRLAAAEEES-----GMSSSKRFLRSCSASCMPHGAR 745

  Fly   560 QPEWPAQT--------------STHSSFSKSAPNLDKKQQQQNQ-QQVASLT--PPPGL------ 601
            ..||.:.|              ||........|.|.:|:..::: :|||..|  |||.|
Mouse   746 DTEWRSVTLPRDLPSAGKQFDSSTFGGHKSEKPALPRKRTSESRSEQVAKSTAMPPPRLVKKNEE 810

  Fly   602 ----GILGGSGGAGGTPATPLLYPGIPIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNS 662
                |........|.:|  |.|.|.:                     :....|.:.::..::...
Mouse   811 AAEEGFKDTESSPGSSP--PSLTPKL---------------------LRRQVTASPSSGLSHKEE 852

  Fly   663 ISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYG 727
            .:..:.:.:...:|......:|:..|                  |..:|:......|:..|:..|
Mouse   853 ATKGSASGMGTPATAEPAPPSNKVGL------------------SKASSEEMRVRRHKHSSESPG 899

  Fly   728 LDH----PLAYQPPPLYLVT--------DDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFG 780
            .|.    .|...|||....|        ..|.|......||      |:..:|.|..||:.   .
Mouse   900 RDKGRLAKLKPAPPPPPACTGKAGKPAQSPSQEAGEAGGPT------KTKCTSLAMDAVNT---D 955

  Fly   781 GSLGNSPAVGRKKHSLDS-----SSHHPPANGSNSFALPNQLTLPSE---DNNTYDHAFYRDVIK 837
            .:....|..|.:|....|     |:..||...::..:.|:....||.   |......||...:..
Mouse   956 PTKAGPPGEGLRKPVPPSVPKPQSTAKPPGTPTSPVSTPSTAPAPSPLAGDQQPSSAAFIPLIST 1020

  Fly   838 KMSMASS----ERVNSKSSGDLT 856
            ::|:..:    ||:   :||.:|
Mouse  1021 RVSLRKTRQPPERI---ASGTIT 1040

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	17/93 (18%)
		TyrKc	129..386	CDD:197581	89/268 (33%)
		STKc_MLK	134..389	CDD:270963	89/266 (33%)
Abl1	NP_001106174.1	SH3_Abl	84..137	CDD:212784	16/56 (29%)
		SH2_ABL	142..235	CDD:198189	5/92 (5%)
		PTKc_Abl	254..516	CDD:270645	92/279 (33%)
		Pkinase_Tyr	261..512	CDD:285015	89/268 (33%)
		FABD	1018..1142	CDD:197885	6/26 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810