Protein Alignment slpr and Tak1

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_003436321.2
• Gene: Tak1 / 11175763
• VectorBaseID: AGAMI1_014337
• Length: 611
• Species: Anopheles gambiae
• Alignment Length: 682
• Identity: 159/682 - (23%)
• Similarity: 248/682 - (36%)
• Gaps: 166/682 - (24%)

  Fly   124 IEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRMRDNVL-QEAKLFWALKHEN 187
            |:.||::....:|.|.:..|.:..:..:.||:|.        |:.:.:... .|......:.|.|
Mosquito    19 IDINEIEQIATVGKGSYGTVIKAKWRNKYVAVKY--------MEVLTEQAFTAEVSHLSRVAHPN 75

  Fly   188 IAALRGVCL-NTKLCLVMEYARGGSLNRILAGKIPPDV----LVNWAIQIARGMNYLHNEAPMSI 247
            |..|.|.|. ....|||||||.||||:::|..:..|..    .::||.|.|.|:.|||:..|..:
Mosquito    76 IIELYGACTEKPNFCLVMEYADGGSLHKVLHSRPRPVYTAAHAMSWARQCAEGVAYLHDMTPRPM 140

  Fly   248 IHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAGTYAWMPPEVISVSTYSKF 312
            ||||||..|:|:..       ....|||.|||...:. :|...:..|:.|||.|||...|:|::.
Mosquito   141 IHRDLKPPNLLLVN-------NGTVLKICDFGTVTDK-STLMTNNKGSAAWMAPEVFEGSSYTEK 197

  Fly   313 SDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNT---LTLPIPKTCPETWGALMKSCWQTDPH 374
            .||:|:|::|||:|..|.|:|..|   .:|.:....   ...|:...||:....||..||..||.
Mosquito   198 CDVFSWGIILWEVIAREQPFKHID---TSYAIMWRVHQGSRPPLIDHCPKPIEQLMVRCWDKDPI 259

  Fly   375 KRPGFKEILKQLESIACSKFT----------LTPQESFHYMQECWRKEIAGVLHDLREKEKRFQT 429
            .||..||::..:.:: |..||          |...|...|          |:.:.:.      ..
Mosquito   260 SRPSMKEVVNVMNAL-CKLFTGENEPIGNEFLPEDEDDSY----------GMAYPIE------SN 307

  Fly   430 IEEELRN---KEEQLLRVQNEQREKANLLKIREQNLRE-RERVLIERELVMLQPVPSKRKHKKGK 490
            :.|.:.|   .......:.|:...:..|...|:..||. ...||::...|.:.|.
Mosquito   308 VSEGMDNGIDTNSSHGTITNKNTVQRLLDMPRDSPLRNVPSNVLLQPLHVDVNPF---------- 362

  Fly   491 KNKPLQISLPTGFRHTITAVRDKAEQP-GSPSFSGLRIVALTDGHK------------GKTWGP- 541
             ::|:::.             ..|..| .|....||.:...|:...            ..|.||
Mosquito   363 -DQPMELG-------------SGALYPANSQGTEGLTVTKCTNAPMDSVSSINSSITFNSTTGPG 413

  Fly   542 -STMHQRERSLLPSQL-----SGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPG 600
             :..|...|..:|..:     .||:                  .::.:||||.:::.......
Mosquito   414 IAAHHDPARPTMPPNVPRPLADGGE------------------CIEAEQQQQEEEEDEEENRE-- 458

  Fly   601 LGILGGSG--------GAGGTPATPLLYPGIPIILTRPNN---NNIGNCKAITTT-----ITTTT 649
             ||:.|.|        .|.|.....:|.|.:..:...|||   ..|.|...:...     .|...
Mosquito   459 -GIVVGGGRSSSKQNEAALGDTLYSILDPNLRPLTPVPNNPLSEQIHNEHKLLVQKYFEFETQIV 522

  Fly   650 TTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNLTSQPNTIIVLQNGRNNSNSSTTSQSP 714
            |:........||.:.    .:|.............:..|..:.|    ||...|:.|..
Mosquito   523 TSMAQREMLQNNMLP----EELQLKKAYIKRLEEREALLKFKAN----LQKQLNDKNRQ------ 573

  Fly   715 AKIYHRARSQEYGLDHPLAYQPPPLYLVTDDS 746
                .:||.|:        ..||||:....||
Mosquito   574 ----QQARQQQ--------QHPPPLHRQESDS 593

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		STKc_MLK	134..389	CDD:270963	86/263 (33%)
Tak1	XP_003436321.2	None