DRSC/TRiP Functional Genomics Resources

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Protein Alignment slpr and RIPK3

DIOPT Version :10

Sequence 1:NP_001188558.1 Gene:slpr / 44111 FlyBaseID:FBgn0030018 Length:1155 Species:Drosophila melanogaster
Sequence 2:NP_006862.2 Gene:RIPK3 / 11035 HGNCID:10021 Length:518 Species:Homo sapiens


Alignment Length:576 Identity:139/576 - (24%)
Similarity:218/576 - (37%) Gaps:161/576 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 IEYNELDIKEVIGSGGFCKVHRGYYD--GEEVAIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHE 186
            :...||:.:|::|.|||..|.|..:.  |.:||:||.:...          :.:|.|...:|.:|
Human    16 VSIEELENQELVGKGGFGTVFRAQHRKWGYDVAVKIVNSKA----------ISREVKAMASLDNE 70

  Fly   187 NIAALRGVC------LNTKLCLVMEYARGGSLNRILAGKIPPDVLVNWAI------QIARGMNYL 239
            .:..|.||.      .:.|..||.::...|||:.:|..:.|..    |.:      ::..||.||
Human    71 FVLRLEGVIEKVNWDQDPKPALVTKFMENGSLSGLLQSQCPRP----WPLLCRLLKEVVLGMFYL 131

  Fly   240 HNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAA----GTYAWMP 300
            |::.|: ::|||||.||||:...:.        :|:.||||:.....:|..:.:    ||..::.
Human   132 HDQNPV-LLHRDLKPSNVLLDPELH--------VKLADFGLSTFQGGSQSGTGSGEPGGTLGYLA 187

  Fly   301 PEV-ISVS-TYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAVNTLTLP----IPKTCPE 359
            ||: ::|: ..|..|||:|:|:|:|.::.|.......:| |:.|....|....|    :|:..||
Human   188 PELFVNVNRKASTASDVYSFGILMWAVLAGREVELPTEP-SLVYEAVCNRQNRPSLAELPQAGPE 251

  Fly   360 TWG-----ALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGV--- 416
            |.|     .||:.||.::|..||.|:|.|.:.:            |.|..::......::.|   
Human   252 TPGLEGLKELMQLCWSSEPKDRPSFQECLPKTD------------EVFQMVENNMNAAVSTVKDF 304

  Fly   417 LHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIEREL--VMLQP 479
            |..||...:||...|......|....|...|             |...|..|::...|  :.|:.
Human   305 LSQLRSSNRRFSIPESGQGGTEMDGFRRTIE-------------NQHSRNDVMVSEWLNKLNLEE 356

  Fly   480 VPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPSTM 544
            .||....|.....|                 |.:|::...|                :.|...| 
Human   357 PPSSVPKKCPSLTK-----------------RSRAQEEQVP----------------QAWTAGT- 387

  Fly   545 HQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDKKQQQQNQQQVASLTPPPGLGILGGSG- 608
                     |..|..||....:|||.                :||....:.|..|..|..|..| 
Human   388 ---------SSDSMAQPPQTPETSTF----------------RNQMPSPTSTGTPSPGPRGNQGA 427

  Fly   609 ---GAGGTPATPLLYP--GIPIILTRPNNNNIGNCKAITT------TITTTTTTTT 653
               |...:..||...|  |.|::       ||.||..:..      |:..||...|
Human   428 ERQGMNWSCRTPEPNPVTGRPLV-------NIYNCSGVQVGDNNYLTMQQTTALPT 476

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
slprNP_001188558.1 SH3_MLK 47..104 CDD:212809
STKc_MLK 134..389 CDD:270963 82/283 (29%)
RIPK3NP_006862.2 Protein Kinases, catalytic domain 27..280 CDD:473864 81/276 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 355..443 26/146 (18%)
RHIM 448..468 CDD:463679 5/26 (19%)
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000269|PubMed:29681455 450..466 4/22 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 476..518 1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

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