DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and map3k9

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_002936940.2	Gene:	map3k9 / 100488949	XenbaseID:	XB-GENE-989075	Length:	1104	Species:	Xenopus tropicalis

Alignment Length:	1109	Identity:	381/1109 - (34%)
Similarity:	517/1109 - (46%)	Gaps:	262/1109 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 EQVETQVGDGSLWTALYDYDAQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGVFPKD 100
            ||..:...:...|||::||:|..|||||||.|::|.|||.||.||||.|||||||.|:||:||.:
Frog    73 EQPSSSTSNPLYWTAVFDYEASAEDELTLRLGDLVQVLSKDSSVSGDEGWWTGKIQDRVGIFPSN 137

  Fly   101 FVTDE------------DPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEV 153
            :||..            :.|....:||   :|..||:::|:.::|:||.|||.||:|..:..|||
Frog   138 YVTRTQSFSSKLQGKRVEELPCYPASA---LQLEEIDFSEMVLEEIIGIGGFGKVYRAIWGQEEV 199

  Fly   154 AIKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCL-NTKLCLVMEYARGGSLNRILA 217
            |:|.|....::|:.:..:||.||||||..|.|.||.||||||| ...||||||:||||||||:|:
Frog   200 AVKAARHDPDEDISQTIENVRQEAKLFAMLDHPNIIALRGVCLKEPNLCLVMEFARGGSLNRVLS 264

  Fly   218 G-KIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLA 281
            | |||||:|||||:|||||||||||||.:.:||||||||||||.:.:|...|.:|.|||||||||
Frog   265 GKKIPPDILVNWAVQIARGMNYLHNEAIVPVIHRDLKSSNVLILQMVENGDLSKKILKITDFGLA 329

  Fly   282 REMYNTQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVAV 346
            ||.:.|.:||||||||||.||||..|.:||.|||||||||||||:|||.|::|.|.|:||||||:
Frog   330 REWHRTTKMSAAGTYAWMAPEVIRSSMFSKGSDVWSYGVLLWELLTGEVPFRGIDGLAVAYGVAM 394

  Fly   347 NTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRK 411
            |.|:||||.||||.:..||:.||..|||.||.|..||.||.:|..|.|...|:||||.:||.|::
Frog   395 NKLSLPIPSTCPEPFARLMEDCWNPDPHCRPPFTNILFQLTTIEESGFFEMPKESFHSLQEDWKR 459

  Fly   412 EIAGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVM 476
            ||..:...||.|||       |||:.||:|.|...||:....||:.|||.|.|||..::||||.:
Frog   460 EIQEMFDQLRAKEK-------ELRSWEEELSRAALEQKNHEELLRRREQELAEREIDILERELNI 517

  Fly   477 L-----QPVPSKRKHK-KGKKNK-PLQ----ISLPTGFRHTITA------------VRDKAEQPG 518
            :     |..|..:|.| |.|||| .|:    ||||:.|:|..|.            :..|...|.
Frog   518 IIHQLCQEKPKVKKRKGKFKKNKLKLKDGNIISLPSDFQHKFTVQASPTMDKRKSLINTKFSPPA 582

  Fly   519 SPS-FSGLRIVALTDGHKGKTWGPSTMHQRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPNLDK 582
            ||: ...||.:.||.|....|...||...::.|                           ...:|
Frog   583 SPTIIPRLRAIQLTPGDSNITKNCSTAGLKDES---------------------------EEDEK 620

  Fly   583 KQQQQNQQQVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPIILTRPNNNNIGN---------- 637
            |:.::..:..||       |.||......|.........|:     :|.::|..|
Frog   621 KETKKKVRTWAS-------GALGNRDSGAGEEGLRASAEGL-----KPCSSNTSNHGKPLRTSST 673

  Fly   638 --CKAITTTITTTTTTTTNNNNNNNNSISANNNNQL-------NNISTINSNNNNNQTNLTSQPN 693
              ..|:|.|....|..|.|..::..:.....|.:.|       :::....|:.:.|.|.:
Frog   674 PGFNAVTETGVENTADTANQADSKESHTPTPNKSYLCIPFHKGDDVEGPFSDTSENPTPV----- 733

  Fly   694 TIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDDSSETDTVASPTGC 758
                      ||.:||...:|      ..|.:.|..|...    .|.|:              ||
Frog   734 ----------NSANSTPQLTP------TNSLKRGSQHKRC----SLVLL--------------GC 764

  Fly   759 ----------FHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSL----------------- 796
                      |..:::|..          :.|..........:||.||
Frog   765 GALLATVGLGFDLMEAGKC----------QLGQEEPEPKEEKKKKESLFQRAARPRRSTSPPSKK 819

  Fly   797 -----DSSSHHPPANGSNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDLT 856
                 :|.||  ||..:.|..| ..|:..||.|:|      |.:::            ..|.:|.
Frog   820 LFRKEESPSH--PAEPTTSLTL-QSLSSISECNST------RSLLR------------SDSDELI 863

  Fly   857 MYNSST------------PLTARDCDDAEEAFEGGRFQRNFSGSQFPRHCFFTRQEEEG--EAED 907
            :|...|            ||.....:         .|:|:.:.|..|.|.....:..:.  ....
Frog   864 VYEMPTSPVEEQPPVVINPLVNVHIE---------TFKRDPNQSLTPTHVTMNSRVHQAHRRTPS 919

  Fly   908 EDAVAAEVDTADADADDECQVPASQMRQNSTTSR---------KSSVTF----------QSVSFE 953
            :.|:.|....|:..:.:.|.|..:......:.||         ..::.|          |..:.|
Frog   920 DGAIKAVSVIANGTSPNNCLVSCTGTSNVPSPSRDMHDFPRLPDPNLIFPPTPRRWNMQQDSALE 984

  Fly   954 EP---DFVATPRTTARSDLYTSSASISFATYRSASPSLSSSSTTAS------ASPSIASTE---A 1006
            .|   :||..||.:.......|...:|.:..|..||:.||.:.|.|      ||.|.::.|   |
Frog   985 RPNTLEFVPRPRPSTNRQRLDSWWFVSPSRNRGESPANSSCTDTPSNMDSCFASSSGSTVEERPA 1049

  Fly  1007 VNGY 1010
            ..|:
Frog  1050 FTGF 1053

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	37/56 (66%)
		TyrKc	129..386	CDD:197581	166/258 (64%)
		STKc_MLK	134..389	CDD:270963	167/256 (65%)
map3k9	XP_002936940.2	SH3_MLK1-3	84..141	CDD:212992	37/56 (66%)
map3k9	XP_002936940.2	STKc_MLK1	168..437	CDD:271047	171/268 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	337	1.000	Domainoid score	I1119
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001334
OrthoInspector	1	1.000	-	-		otm49427
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4635
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030