Protein Alignment slpr and map3k12

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_004912001.1
• Gene: map3k12 / 100488307
• XenbaseID: XB-GENE-482768
• Length: 814
• Species: Xenopus tropicalis
• Alignment Length: 901
• Identity: 244/901 - (27%)
• Similarity: 367/901 - (40%)
• Gaps: 231/901 - (25%)

  Fly    34 DLEQVETQVGDGSLWTALYDYD--AQGEDELTLRRGEIVVVLSTDSEVSGDVGWWTGKIGDKVGV 96
            |.::.|.:.|.|:....|.|..  |.||..:..:.|               ||:..|..|....|
 Frog    74 DPQKAEDRGGGGAADCPLEDRPCRALGEGRMQCQAG---------------VGFLGGLFGCLRPV 123

  Fly    97 FP---KDFVTD----EDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVA 154
            :.   |.:.|:    ||              |.|:.:.|:...:.:|||....|..|.:.|:|||
 Frog   124 WAMIGKTYSTEHKQGED--------------PWEVPFEEIQDLQWVGSGAQGAVFLGKFHGDEVA 174

  Fly   155 IKIAHQTGEDDMQRMRDNVLQEAKLFWALKHENIAALRGVCLNTK-LCLVMEYARGGSLNRIL-A 217
            :|......|.|::.:|           .|||.||...:|||.... .|::||:...|.|..:| |
 Frog   175 VKKVRDIKETDIKHLR-----------KLKHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLRA 228

  Fly   218 G-KIPPDVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLI-YEAIEGNHLQQKTLKITDFGL 280
            | ||.|.:||:|::.||.||||||..   .||||||||.|:|| |:.:         :||:|||.
 Frog   229 GRKITPSLLVDWSMGIAGGMNYLHLH---KIIHRDLKSPNMLITYDDL---------VKISDFGT 281

  Fly   281 AREMYN-TQRMSAAGTYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGV 344
            ::|:.: :.:||.|||.|||.||||.....|:..|:||:||:||||:|||.|||..|..::.:||
 Frog   282 SKELSDKSTKMSFAGTVAWMAPEVIRNEPVSEKVDIWSFGVVLWELLTGEIPYKDVDSSAIIWGV 346

  Fly   345 AVNTLTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECW 409
            ..|:|.||:|.:||:.:..|::.||.:.|..||.|::||..|: ||.:....||||::...|..|
 Frog   347 GSNSLHLPVPSSCPDGFKLLLRQCWDSKPRNRPSFRQILCHLD-IASADVLSTPQETYFKSQVEW 410

  Fly   410 RKEIAGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQRE-------KANL-----------LK 456
            |.|:......::.:....|.:||||..:..:.||...:.||       :||.           |:
 Frog   411 RDEVRLHFEKIKSEGTCLQRLEEELITRRREELRHALDIREHYERKLQRANTLYVELNSLMLQLE 475

  Fly   457 IREQNLRERERVLIERELVML--QPVPSKRKHKKGKK-NKPLQISLPTGFRHTITAVR------D 512
            ::|:.|..||::|.::...:|  ||.||....|..|| |.|.::| |.|.|..|....      |
 Frog   476 LKEKELLRREQILEKKYPAILRQQPRPSSTVEKLIKKRNVPQKLS-PHGKRPDILKSEVLLPKVD 539

  Fly   513 KAEQPGSPSFSGLRIVALTDGHKGKTWGP-----STMHQRERSLLPSQLSGGQPEWPAQTSTHSS 572
            ....|.:|  :|.:.:..:.| :|:...|     ..|.....::.|......||  ||: ..| .
 Frog   540 SVLSPSTP--TGCQKLPPSPG-RGRRGKPRYRKAKDMVNLRAAVTPEPTPQSQP--PAR-DPH-P 597

  Fly   573 FSKSAPNL---------DKKQQQQNQQQVASLTPPPG----LGILGGSGGA-GGTPATPLLYPGI 623
            .|.|:|:|         .:..|......|.||..||.    .|...||..| ||...||
 Frog   598 LSSSSPDLLCTPLEAEARRGSQSAESSPVRSLPGPPSPDSPSGRAAGSRAARGGQHLTP------ 656

  Fly   624 PIILTRPNNNNIGNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTINSNNNNNQTNL 688
                         :.:.....:|                     .:|...:|     :...:..:
 Frog   657 -------------SARLYRAAVT---------------------RSQKRGLS-----SEEEEGEV 682

  Fly   689 TSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLDHPLAYQPPPLYLVTDDSSETDTVA 753
            .|:      |:..|..|...|.........:::.|.|...|........|.:.||.|...|:|..
 Frog   683 DSE------LEMERRQSGGVTCRWPTGMSQNQSPSSENLSDGEEGNTTDPSHSVTPDVLSTNTDE 741

  Fly   754 SPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGRKKHSLDSSSHHPPANGSNSFALPNQLT 818
            .|..                                  :...|.|.|..||.:           .
 Frog   742 RPDD----------------------------------RSEDLVSQSSEPPLD-----------L 761

  Fly   819 LPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGD-LTMYNSSTPLTARDCDDAE 873
            |...|..:...|    ||:|:....|   |.:::|: :.:|:.|      |||.||
 Frog   762 LTQSDGLSEKEA----VIQKVKTQLS---NEQTAGENVVLYDDS------DCDSAE 804

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	12/61 (20%)
		STKc_MLK	134..389	CDD:270963	109/259 (42%)
map3k12	XP_004912001.1	STKc_MAP3K12_13	155..391	CDD:270961	109/259 (42%)