Protein Alignment slpr and abl2

DIOPT Version :10

• Sequence 1: NP_001188558.1
• Gene: slpr / 44111
• FlyBaseID: FBgn0030018
• Length: 1155
• Species: Drosophila melanogaster
• Sequence 2: XP_002937405.1
• Gene: abl2 / 100487790
• XenbaseID: XB-GENE-6459814
• Length: 1100
• Species: Xenopus tropicalis
• Alignment Length: 995
• Identity: 229/995 - (23%)
• Similarity: 347/995 - (34%)
• Gaps: 355/995 - (35%)

  Fly    18 QLEQLHHPQIPEIPIPDLEQV------ETQVG----DGSLWTALYDYDAQGEDELTLRRGEIVVV 72
            |.|.||.|...:.....|...      |..:|    |.:|:.||||:.|.|::.|::.:||.:.|
 Frog    61 QHEALHRPYGSDSEPQALTDAIRWSSKENLLGATESDPNLFLALYDFVASGDNTLSITKGEKLRV 125

  Fly    73 LSTDSEVSGDVGWW---TGKIGDKVGVFPKDFVT------------------------------- 103
            |..:..     |.|   ..|.|.  |..|.:::|
 Frog   126 LCYNQN-----GEWCEVLSKNGQ--GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGS 183

  Fly   104 ------DEDPLQLNVS--------------------------------------SAIGD------ 118
                  :..|.||::|                                      |.:.|
 Frog   184 FLVRESESSPGQLSISLRYEGRVYHYRINTASDGKVYVTAESRFNTLAELVHHHSTVADGLVTIL 248

  Fly   119 --------------IQP-H---EIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDD 165
                          :.| |   |:|..::.:|..:|.|.:.:|:.|.:  ::..:.:|.:|.::|
 Frog   249 HYPAPKCNKPTVYGVSPIHDKWEMERTDITMKHKLGGGQYGEVYVGVW--KKYNLTVAVKTLKED 311

  Fly   166 MQRMRDNVLQEAKLFWALKHENIAALRGVC-LNTKLCLVMEYARGGSL-------NRILAGKIPP 222
            ...: :..|:||.:...:||.|:..|.||| |.....:|.||...|:|       ||   .::..
 Frog   312 TMEV-EEFLKEAAVMKEIKHPNLVQLLGVCTLEPPFYIVTEYMHYGNLLDYLRECNR---EEVTA 372

  Fly   223 DVLVNWAIQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNT 287
            .||:..|.||:..|.||..:   :.|||||.:.|.|:.|    ||:    :|:.||||:|.|...
 Frog   373 VVLLYMATQISSAMEYLERK---NFIHRDLAARNCLVGE----NHV----VKVADFGLSRLMTGD 426

  Fly   288 QRMSAAGT---YAWMPPEVISVSTYSKFSDVWSYGVLLWELIT-GETPYKGFDPLSVAYGVAVNT 348
            ...:.||.   ..|..||.::.:|:|..||||::||||||:.| |.:||.|.| ||..|.:....
 Frog   427 TYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLLWEIATYGMSPYPGID-LSQVYDLLEKG 490

  Fly   349 LTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEI 413
            ..:..|:.||.....||::|||.:|..||.|.|..:..|:
 Frog   491 YRMEQPEGCPPKVYELMRACWQWNPSDRPSFSETHQAFET------------------------- 530

  Fly   414 AGVLHDLREKEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQ 478
              :.||....|:    :.|||.........|..:.|                           |.
 Frog   531 --MFHDSNINEE----VAEELGRTAVTSSSVSYQCR---------------------------LP 562

  Fly   479 PVPSK-RKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGLRIVALTDGHKGKTWGPS 542
            .:||| |..||..:||           ..|....|.::...|.|..|     |..|....:..|:
 Frog   563 MLPSKSRTLKKKAENK-----------ENIEGTGDSSDNSTSSSTPG-----LLHGSPVASGSPA 611

  Fly   543 TMHQRERSLLPSQLSGGQPEWPAQTSTH-------SSF--SKSAPNLDKK----QQQQNQ----- 589
             :.:::|...||.|.|...|   .|.|.       |||  .||||...|:    ::.:||
 Frog   612 -LPRKQRDKSPSSLLGDTKE---TTFTRDRKGGFFSSFMKKKSAPQPPKRSSSFREMENQPHKRP 672

  Fly   590 ---------QQVASLTPPPGLG-----------------ILGGSGGAGGTPATPLLYPGIPIILT 628
                     ||:.||..|...|                 ::||.|| |.|..:....|
 Frog   673 ELTGELPSFQQLDSLDSPASPGSHKCYGGGSQRSFPPEDVIGGIGG-GWTGISGFFTP------- 729

  Fly   629 RPNNNNIGNCKAITTTITTTTTTTTNN--------NNNNNNSISANNNNQLNNISTINSNNNNNQ 685
                      :.|..|....|..:.::        .:|:.:|:|.....|.....|:..|.:..:
 Frog   730 ----------RLIKKTFGLRTGKSGSSGEEPKPFPRSNSTSSMSPAVPEQDRLSMTLPRNCHRTK 784

  Fly   686 TNLTSQPNTIIVLQNGRNNSNSSTTSQSPAKIYHRARSQEYGLD-HPLAYQPPPLYLVTDDSSE- 748
            ..|                ..:::.|..|.:..|..  |..||: .|:..:..|..|.....||
 Frog   785 VQL----------------DRTTSISSQPEESQHDL--QRSGLEIQPVRDRVKPKMLPRTGVSER 831

  Fly   749 -------TDTVASP---TGCFHFLKSGNSSAASGAVHLHRFGGSLGNSP--------AVGRKKHS 795
                   .|..:||   ||       |.:||.|.|.|.|:....:..||        .||
 Frog   832 NGGLRTGADEKSSPNKHTG-------GATSAFSTAAHNHKVPVLISPSPRNASTEVQLVG----- 884

  Fly   796 LDSSSH-------HPPANGS 808
            :||..|       |.|..||
 Frog   885 MDSLGHTFKLLQEHVPPTGS 904

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809	19/96 (20%)
		STKc_MLK	134..389	CDD:270963	90/266 (34%)
abl2	XP_002937405.1	SH3_Abl	100..153	CDD:212784	18/59 (31%)
		SH2_ABL	158..251	CDD:198189	6/92 (7%)
		PTKc_Abl	270..532	CDD:270645	93/306 (30%)
		F_actin_bind	984..1100	CDD:471692