DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment slpr and ankk1

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	NP_001124137.1	Gene:	ankk1 / 100170831	ZFINID:	ZDB-GENE-071015-4	Length:	733	Species:	Danio rerio

Alignment Length:	864	Identity:	180/864 - (20%)
Similarity:	317/864 - (36%)	Gaps:	264/864 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 DIKEVIGSG---GFCKVHRGYYDGE-------------EVAIKI-----AHQTGEDDMQRMRDNV 173
            |:|:....|   ||....:..::.:             :|.:|:     |.:|..:|.:    |:
Zfish     7 DVKDSFKDGSLEGFSYFKKDEFESDWEKLVERKFGRVYKVKLKVLRETCALKTTTNDYR----NI 67

  Fly   174 LQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAGKIPPDVLVNW------AIQI 232
            ::.:|: ..:|...:.::.|:|.:.. .|||||.|.|||:.:|:..     |:.|      ..::
Zfish    68 MEISKI-GRMKFNYLISIYGICKDPP-ALVMEYMRKGSLDNLLSNH-----LLMWPKKFQMIHEM 125

  Fly   233 ARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNT-----QRMSA 292
            ..|||:||:..| .|:|.:||.:|:|:     .:||.   :||:|||..:..:::     :.:.|
Zfish   126 TMGMNFLHSMKP-PILHLNLKPANILL-----DDHLH---VKISDFGFIKWEFSSKTEFIEHLMA 181

  Fly   293 AGTYAWMPPEVISVSTY---SKFSDVWSYGVLLWELITGETPYKGFDPLSVAYGVA------VNT 348
            .|...::|||.:|.:..   :|: ||:|:.:::||::|.:..|.|.....:...|:      |..
Zfish   182 RGNINYVPPETLSQNPEPPGTKY-DVYSFSIIMWEILTQKRSYAGLSMTEILIRVSSGKRPGVEK 245

  Fly   349 LTLPIPKTCPETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEI 413
            :....|..|.:..| :|:.||..|...||.|.:.::..|.:  |:....| ::|.      |:||
Zfish   246 IPEDKPPECEDMIG-VMQQCWNQDSRSRPPFSKTVRLTEVL--SEVLKIP-DTFS------RREI 300

  Fly   414 AGVLHDLREK---------------EKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLR 463
            ...|.:..:|               .|.|.:.::.:|.:...:|...|      |.|........
Zfish   301 RKRLPEQPKKTADSSDDSSIQSLLVRKDFNSFKKVVRKEHVSMLFQDN------NSLLHHAVAGG 359

  Fly   464 ERERVLIEREL---VMLQPVPSKRKHKKGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSGL 525
            :||.|.:...|   |..|.|         |...||.:::...|....:.:.|....
Zfish   360 DRESVQMVLNLGASVNCQSV---------KGYTPLIVAVLHKFYEICSLLTDCGAD--------- 406

  Fly   526 RIVALTDGHKGKTWGPSTMH--------QRERSLLPSQLSGGQPEWPAQTSTHSSFSKSAPN--- 579
              |.|:||.:   |  :.:|        :..|.||.::......|....|..|.:......|
Zfish   407 --VNLSDGDQ---W--TALHFAVQAGDDRATRFLLDNKARADAKEKDGWTPLHLAAQNGHENIVR 464

  Fly   580 -----LDKKQQQQNQQ-----QVASLTPPPGLGILGGSGGAGGTPATPLLYPGIPII-------- 626
                 ||....|::|.     .|||                        :|..|.|:
Zfish   465 ILLRRLDSVDVQEHQSCRTALHVAS------------------------IYGHINIVKLLLNKGA 505

  Fly   627 -LTRPNNNNI---------GNCKAITTTITTTTTTTTNNNNNNNNSISANNNNQLNNISTI---- 677
             :.:.:||..         |:.:.:...:.:....    |..:..|.|:.:...||..:.|
Zfish   506 DIDKQDNNQSTALHLAAEEGHFRVVRLLVNSGADV----NKVDEQSYSSLHFAALNGYTGICRLL 566

  Fly   678 -------NSNNNNNQT-----NLTSQPNTIIVLQNGRNNSN----SSTTSQSPAKIYHRARSQEY 726
                   ||..|.|.|     .|...|..|:.|:..:.:.|    :..|
Zfish   567 LSKGIDPNSRTNKNWTAMHLAALKGHPEIILTLEEHQGSVNIQGKNGWT---------------- 615

  Fly   727 GLDHPLAYQPPPLYLVTDDSSETDTVASPTGCFHFLKSGNSSAASGAVHLHRFGGSLGNSPAVGR 791
                       ||:|......| :.|   ||........|.:..:|...||....| .:.|:|
Zfish   616 -----------PLHLACHHGQE-EVV---TGLLTAGADPNLAEDNGWTPLHLACNS-SSFPSV-- 662

  Fly   792 KKHSLDSSSHHPPANG-SNSFALPNQLTLPSEDNNTYDHAFYRDVIKKMSMASSERVNSKSSGDL 855
                |...||....|. :||.:.|  |.|.::.:|.       .:||.:.|.:::|....|.|
Zfish   663 ----LQLISHKANVNAQNNSQSTP--LHLAAQLSNI-------PIIKALLMNNAQREMQDSKG-- 712

  Fly   856 TMYNSSTPLT-ARDCDDAE 873
                 .|.|| |:.|:::|
Zfish   713 -----CTALTLAQQCNNSE 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	73/296 (25%)
		STKc_MLK	134..389	CDD:270963	72/295 (24%)
ankk1	NP_001124137.1	PKc_like	32..289	CDD:304357	70/280 (25%)
		STYKc	33..276	CDD:214568	67/264 (25%)
		ANK repeat	347..378	CDD:293786	8/36 (22%)
		Ank_2	352..443	CDD:289560	21/115 (18%)
		ANK	375..501	CDD:238125	30/174 (17%)
		ANK repeat	381..411	CDD:293786	6/40 (15%)
		ANK repeat	413..444	CDD:293786	5/35 (14%)
		Ank_2	418..511	CDD:289560	18/116 (16%)
		ANK	441..567	CDD:238125	23/153 (15%)
		ANK repeat	446..477	CDD:293786	5/30 (17%)
		ANK repeat	479..511	CDD:293786	7/55 (13%)
		Ank_2	485..576	CDD:289560	16/118 (14%)
		ANK	508..629	CDD:238125	24/152 (16%)
		ANK repeat	513..544	CDD:293786	3/34 (9%)
		ANK repeat	546..576	CDD:293786	6/29 (21%)
		Ank_2	551..641	CDD:289560	21/120 (18%)
		ANK repeat	581..610	CDD:293786	6/28 (21%)
		ANK	607..731	CDD:238125	38/174 (22%)
		ANK repeat	612..643	CDD:293786	9/61 (15%)
		Ank_2	617..709	CDD:289560	27/111 (24%)
		ANK repeat	645..676	CDD:293786	10/37 (27%)
		ANK repeat	678..709	CDD:293786	9/39 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0192
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810