DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment slpr and map3k7

DIOPT Version :9

Sequence 1:	NP_001188558.1	Gene:	slpr / 44111	FlyBaseID:	FBgn0030018	Length:	1155	Species:	Drosophila melanogaster
Sequence 2:	XP_012818037.1	Gene:	map3k7 / 100101764	XenbaseID:	XB-GENE-481530	Length:	617	Species:	Xenopus tropicalis

Alignment Length:	565	Identity:	157/565 - (27%)
Similarity:	233/565 - (41%)	Gaps:	112/565 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 EDPLQLNVSSAIGDIQPHEIEYNELDIKEVIGSGGFCKVHRGYYDGEEVAIKIAHQTGEDDMQRM 169
            |.|..||.         .||:|.|::::||:|.|.|..|.:..:.|::||||......|
Frog    10 ETPPVLNF---------EEIDYKEIEVEEVVGRGTFGVVCKAKWRGKDVAIKQIESESE------ 59

  Fly   170 RDNVLQEAKLFWALKHENIAALRGVCLNTKLCLVMEYARGGSLNRILAGKIPPDV-----LVNWA 229
            |...:.|.:....:.|.||..|.|.||| .:|||||||.||||..:|.|..|...     .::|.
Frog    60 RKAFIVELRQLSRVNHPNIVKLYGACLN-PVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWC 123

  Fly   230 IQIARGMNYLHNEAPMSIIHRDLKSSNVLIYEAIEGNHLQQKTLKITDFGLAREMYNTQRMSAAG 294
            :|.|:|:.|||:..|.::||||||..|:|:   :.|.    ..|||.|||.|.:: .|...:..|
Frog   124 LQCAQGVAYLHSMKPKALIHRDLKPPNLLL---VAGG----TVLKICDFGTACDI-QTHMTNNKG 180

  Fly   295 TYAWMPPEVISVSTYSKFSDVWSYGVLLWELITGETPYK--GFDPLSVAYGVAVNTLTLPIPKTC 357
            :.|||.|||...|.||:..||:|:|::|||:||...|:.  |.....:.:.|. |....|:.|..
Frog   181 SAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVH-NGTRPPLIKNL 244

  Fly   358 PETWGALMKSCWQTDPHKRPGFKEILKQLESIACSKFTLTPQESFHYMQECWRKEIAGVLHDLRE 422
            |:...:||..||..||.:||..:||:|    |........|.........|...: .|..:....
Frog   245 PKPIESLMTRCWSKDPPQRPSMEEIVK----IMTHLMQYFPGADVSLQYPCQYSD-EGQSNSATS 304

  Fly   423 KEKRFQTIEEELRNKEEQLLRVQNEQREKANLLKIREQNLRERERVLIERELVMLQPVPSKRKHK 487
            .............||.:..:...:.|...:|      ..::.     ||.:|.......||:..:
Frog   305 TGSCIDITSTNTSNKSDINIEAGDFQASASN------DTIKR-----IESKLAQHLKNQSKQSGE 358

  Fly   488 KGKKNKPLQISLPTGFRHTITAVRDKAEQPGSPSFSG---------------LRIVALT------ 531
            .|:      :|||.....::.::.:...:|  ||..|               .||.|.|
Frog   359 TGR------LSLPPSRGSSVESLSEIRGRP--PSTLGTSEGKRMSADMSELEARISASTAAYAKP 415

  Fly   532 -DGH-KGKTWG-----PSTM------HQRERSLLPSQLSGGQPEWPAQTSTHSS------FSKSA 577
             .|| |..::|     |..:      .||.||:....:.|.:....::.|:.||      .:.|.
Frog   416 KRGHRKTASFGNILDVPEIIITAGNGQQRRRSVQDLTIVGTESSQESRNSSRSSSPSVRMITTSG 480

  Fly   578 PNLDKKQQQQNQQQVASLTPPPGL--GILGGSGGAGGTPATPLLY 620
            |..||              ||.||  |....|...|...:.|:.|
Frog   481 PTPDK--------------PPRGLPWGPDESSDTNGSDNSIPMAY 511

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
slpr	NP_001188558.1	SH3_MLK	47..104	CDD:212809
		TyrKc	129..386	CDD:197581	98/263 (37%)
		STKc_MLK	134..389	CDD:270963	97/261 (37%)
map3k7	XP_012818037.1	STKc_TAK1	31..281	CDD:270960	97/269 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D346131at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920