Protein Alignment Optix and six2a

DIOPT Version :10

• Sequence 1: NP_001260793.1
• Gene: Optix / 44108
• FlyBaseID: FBgn0025360
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_571858.1
• Gene: six2a / 83415
• ZFINID: ZDB-GENE-010412-1
• Length: 288
• Species: Danio rerio
• Alignment Length: 320
• Identity: 145/320 - (45%)
• Similarity: 191/320 - (59%)
• Gaps: 63/320 - (19%)

  Fly    32 VPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILNCEAVLRARAVVAYHVGNFR 96
            :||..|:..||..||:.|:..|:||||.||||||| |..::|:   .|:||:|:||||:|.||||
Zfish     4 LPTFGFTQEQVACVCEVLQQGGNIERLGRFLWSLP-ACEHLHK---NESVLKAKAVVAFHRGNFR 64

  Fly    97 ELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTH 161
            |||.|:|:|:|:..::.|||.:||:||||||||||||.||.|.|||||:|||||.:|||||:.::
Zfish    65 ELYKILESHQFSPHNHPKLQQLWLKAHYIEAEKLRGRPLGAVGKYRVRRKFPLPRSIWDGEETSY 129

  Fly   162 CFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNS 226
            ||||::||:|||||..:|||:|.:|||||:||||..|||.|||||||||||||.||.| ::::||
Zfish   130 CFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKER-ENNENS 193

  Fly   227 SGMGCRSRRADGAASPTPSDSSDSDISLGTHSPVPSSLQLQHSPGSTSNGANDREESL-SVDDDK 290
                                      :..:|:|:.||:             |..:..| |.||||
Zfish   194 --------------------------NTNSHNPLTSSM-------------NGNKTILGSSDDDK 219

  Fly   291 PRDLSGSLPLPLSLPLPLASPTHT---PPQLPPGYGGGAGAGPGGPLTGPGCLPPFKLDA 347
                           .|..:|.||   |..|.....|........|..||..:|...:|:
Zfish   220 ---------------TPSGTPDHTSSSPALLLTSNSGLQSLHGLAPPPGPSAIPVPSVDS 264

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:465293	68/112 (61%)
		homeodomain	158..206	CDD:238039	30/47 (64%)
six2a	NP_571858.1	SIX1_SD	9..118	CDD:465293	68/112 (61%)
		homeodomain	129..180	CDD:238039	36/50 (72%)