Protein Alignment Optix and SIX3

DIOPT Version :9

• Sequence 1: NP_001260793.1
• Gene: Optix / 44108
• FlyBaseID: FBgn0025360
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_005404.1
• Gene: SIX3 / 6496
• HGNCID: 10889
• Length: 332
• Species: Homo sapiens
• Alignment Length: 253
• Identity: 175/253 - (69%)
• Similarity: 192/253 - (75%)
• Gaps: 24/253 - (9%)

  Fly     8 GKQPPSESFSPTHHQIIAPSPILAVPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNM 72
            |.:.|.|..|           :..:|||.||..||..||:|||::||||||.||||||||| |..
Human    69 GSRAPPEELS-----------MFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVA-PGA 121

  Fly    73 HEILN-CEAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLG 136
            .|.:| .|::||||||||:|.||||:||.|:|||||||.|:||||||||||||.||||||||.||
Human   122 CEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLG 186

  Fly   137 PVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVG 201
            ||||||||||||||.||||||||||||||||||||||||||||||||:||||||:||||.|||||
Human   187 PVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVG 251

  Fly   202 NWFKNRRQRDRAAAAKNRIQHSQ-NSSGM------GC----RSRRADGAASPTPSDSS 248
            ||||||||||||||||||:||.. ..|||      ||    .:.....|||||.|.||
Human   252 NWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSS 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:293483	86/113 (76%)
		homeodomain	158..206	CDD:238039	44/47 (94%)
SIX3	NP_005404.1	Interaction with TLE5. /evidence=ECO:0000250|UniProtKB:Q62233	72..119		30/58 (52%)
		SIX1_SD	87..200	CDD:374862	86/113 (76%)
		homeodomain	208..256	CDD:238039	44/47 (94%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	232..251		15/18 (83%)
		Bind to RHO promoter. /evidence=ECO:0000250|UniProtKB:Q62233	232..234		1/1 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	258..332		27/52 (52%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158081
Domainoid	1	1.000	175	1.000	Domainoid score	I3653
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002292
OrthoInspector	1	1.000	-	-		otm41628
orthoMCL	1	0.900	-	-		OOG6_105562
Panther	1	1.100	-	-	O	PTHR10390
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2573
SonicParanoid	1	1.000	-	-		X333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.730