Protein Alignment Optix and SIX1

DIOPT Version :9

• Sequence 1: NP_001260793.1
• Gene: Optix / 44108
• FlyBaseID: FBgn0025360
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_005973.1
• Gene: SIX1 / 6495
• HGNCID: 10887
• Length: 284
• Species: Homo sapiens
• Alignment Length: 283
• Identity: 135/283 - (47%)
• Similarity: 183/283 - (64%)
• Gaps: 29/283 - (10%)

  Fly    32 VPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILNCEAVLRARAVVAYHVGNFR 96
            :|:..|:..||..||:.|:..|::|||.||||||| |..::|:   .|:||:|:||||:|.||||
Human     4 LPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLP-ACDHLHK---NESVLKAKAVVAFHRGNFR 64

  Fly    97 ELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTH 161
            |||.|:|:|:|:..::.|||.:||:|||:||||||||.||.|.|||||:|||||.||||||:.::
Human    65 ELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSY 129

  Fly   162 CFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNS 226
            ||||::|.:|||||..:|||:|.:|||||:||||..|||.|||||||||||||.||.|.....|:
Human   130 CFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNN 194

  Fly   227 SGMGCRSRRADGAASPTPSDSSDSDIS-LGTHSPVPSSLQLQHSPGSTSNGANDREESLSVDDDK 290
            |                 |.:..:.:| |....|:.||.:.:.||..:.    |:...|.:..:.
Human   195 S-----------------SSNKQNQLSPLEGGKPLMSSSEEEFSPPQSP----DQNSVLLLQGNM 238

  Fly   291 PRDLSGSLPLPLSLPLPLASPTH 313
            ....|.:..||   .|..:.|:|
Human   239 GHARSSNYSLP---GLTASQPSH 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:293483	66/112 (59%)
		homeodomain	158..206	CDD:238039	29/47 (62%)
SIX1	NP_005973.1	SIX1_SD	9..118	CDD:374862	66/112 (59%)
		homeodomain	129..180	CDD:238039	35/50 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	168..269		35/115 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910