DRSC/TRiP Functional Genomics Resources

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Protein Alignment Optix and SIX4

DIOPT Version :10

Sequence 1:NP_001260793.1 Gene:Optix / 44108 FlyBaseID:FBgn0025360 Length:492 Species:Drosophila melanogaster
Sequence 2:NP_059116.3 Gene:SIX4 / 51804 HGNCID:10890 Length:781 Species:Homo sapiens


Alignment Length:448 Identity:157/448 - (35%)
Similarity:227/448 - (50%) Gaps:71/448 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 SESFSPTHHQIIAPSPILAVPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEIL- 76
            ||.....||...|    .|...||||...|..||:.|:..|:::||||||||||     ..::| 
Human    88 SELLGRHHHAAAA----AAQTPLAFSPDHVACVCEALQQGGNLDRLARFLWSLP-----QSDLLR 143

  Fly    77 NCEAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKY 141
            ..|::|:|||:||:|.|.:.|||:|:|:|.|..|::..||.:|.:|.|.|||:.|||.||.||||
Human   144 GNESLLKARALVAFHQGIYPELYSILESHSFESANHPLLQQLWYKARYTEAERARGRPLGAVDKY 208

  Fly   142 RVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKN 206
            |:|:|||||.||||||:..:||||::|:.|:|.|.|:.||:|.:||.|||.|||:.|||.|||||
Human   209 RLRRKFPLPRTIWDGEETVYCFKEKSRNALKELYKQNRYPSPAEKRHLAKITGLSLTQVSNWFKN 273

  Fly   207 RRQRDRAAAAKNRIQHSQNSSGMGCRSRRADGAASPTP-SDSSD--SDISLGTH----------- 257
            ||||||..:.......|..:......|.:.....||.| |.|||  :::||.:|           
Human   274 RRQRDRNPSETQSKSESDGNPSTEDESSKGHEDLSPHPLSSSSDGITNLSLSSHMEPVYMQQIGN 338

  Fly   258 --------------SPVPSSLQ---------LQHSPGSTSNGAN-DREESLSVDDDKPRDLSGSL 298
                          |.||:|..         :|...|...||.| ...:::::  :.|:..|..:
Human   339 AKISLSSSGVLLNGSLVPASTSPVFLNGNSFIQGPSGVILNGLNVGNTQAVAL--NPPKMSSNIV 401

  Fly   299 PLPLSLPLPLASPTHTPPQLPPGYGGGAGA-----GPGGPLTGPGCLP--PFKLDAATSLFSA-G 355
            ...:|:...|.|.:....:..........|     .|..|::.||.:|  ..|.:...::.|. |
Human   402 SNGISMTDILGSTSQDVKEFKVLQSSANSATTTSYSPSVPVSFPGLIPSTEVKREGIQTVASQDG 466

  Fly   356 CYLQSFSNLKEMSQQFPIQPIVLRPHPQLPQSLA----LNGASGGPPLHHPAYAAAYS 409
            ..:.:|:...:::|...:         |:|.|.|    |||:.|..||..|..:.|.|
Human   467 GSVVTFTTPVQINQYGIV---------QIPNSGANSQFLNGSIGFSPLQLPPVSVAAS 515

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
OptixNP_001260793.1 SIX1_SD 37..150 CDD:465293 57/113 (50%)
homeodomain 158..206 CDD:238039 26/47 (55%)
SIX4NP_059116.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..55
SIX1_SD 108..217 CDD:465293 57/113 (50%)
homeodomain 228..282 CDD:238039 34/53 (64%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 270..321 19/50 (38%)
Blue background indicates that the domain is not in the aligned region.

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