Protein Alignment Optix and SIX6

DIOPT Version :9

• Sequence 1: NP_001260793.1
• Gene: Optix / 44108
• FlyBaseID: FBgn0025360
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_031400.2
• Gene: SIX6 / 4990
• HGNCID: 10892
• Length: 246
• Species: Homo sapiens
• Alignment Length: 251
• Identity: 169/251 - (67%)
• Similarity: 193/251 - (76%)
• Gaps: 12/251 - (4%)

  Fly    32 VPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILN-CEAVLRARAVVAYHVGNF 95
            :|.|.||..||..||:|||:|||:|||.||||||||| |...|.|| .|:||||||:||:|.||:
Human     4 LPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVA-PAACEALNKNESVLRARAIVAFHGGNY 67

  Fly    96 RELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKT 160
            ||||.|:|||||||.|:.||||:||||||.||||||||.||||||||||||||||.|||||||||
Human    68 RELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKT 132

  Fly   161 HCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQN 225
            ||||||||.||||||||||||||:||||||:||||.|||||||||||||||||||||||:|....
Human   133 HCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVL 197

  Fly   226 SSGMGCRSRRADGAASPTPSDSSDSDISLGTHSPVPSSLQLQHSPGSTSNGANDRE 281
            |.|.| |:.||:|..:|.         .||..:...:||..:.:..:.|..::|.|
Human   198 SQGSG-RALRAEGDGTPE---------VLGVATSPAASLSSKAATSAISITSSDSE 243

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:293483	85/113 (75%)
		homeodomain	158..206	CDD:238039	43/47 (91%)
SIX6	NP_031400.2	SIX1_SD	9..122	CDD:318970	85/113 (75%)
		homeodomain	130..178	CDD:238039	43/47 (91%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..246		18/64 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158078
Domainoid	1	1.000	175	1.000	Domainoid score	I3653
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002292
OrthoInspector	1	1.000	-	-		otm41628
orthoMCL	1	0.900	-	-		OOG6_105562
Panther	1	1.100	-	-	LDO	PTHR10390
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2573
SonicParanoid	1	1.000	-	-		X333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	11	10.730