DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Optix and six1a

DIOPT Version :9

Sequence 1:	NP_001260793.1	Gene:	Optix / 44108	FlyBaseID:	FBgn0025360	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001009904.1	Gene:	six1a / 494168	ZFINID:	ZDB-GENE-040718-155	Length:	283	Species:	Danio rerio

Alignment Length:	294	Identity:	141/294 - (47%)
Similarity:	191/294 - (64%)	Gaps:	38/294 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILNCEAVLRARAVVAYHVGNFR 96
            :|:..|:..||..||:.|:..|::|||.||||||| |..::|:   .|:||:|:||||:|.||||
Zfish     4 LPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLP-ACDHLHK---NESVLKAKAVVAFHRGNFR 64

  Fly    97 ELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTH 161
            |||.|:|:::|:..::.|:|.:||:|||:||||||||.||.|.|||||:|||||.||||||:.::
Zfish    65 ELYKILESYQFSTHNHPKMQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSY 129

  Fly   162 CFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNS 226
            ||||::||:|||||..:|||:|.:|||||:||||..|||.|||||||||||||.||.| ::.:|:
Zfish   130 CFKEKSRSVLREWYTHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKER-ENGENN 193

  Fly   227 SGMGCRSRRA--DGAASPTPSDSSDSDISLGTHSPVPSSLQL----QHSPGSTSNGANDREESLS 285
            ...|.:|:|:  ||..|..   ||..|......||..||:.|    .::||:.
Zfish   194 GVGGKQSQRSPLDGVKSLM---SSSEDEFSPPQSPEHSSVLLLQGTMNNPGAP------------ 243

  Fly   286 VDDDKPRDLSGSLPLP-LSLPLPLASPTHTPPQL 318
                       :.|:| |..|.||......|.|:
Zfish   244 -----------AYPMPGLGAPHPLHGMQGHPHQI 266

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:293483	64/112 (57%)
Optix	NP_001260793.1	homeodomain	158..206	CDD:238039	30/47 (64%)
six1a	NP_001009904.1	SIX1_SD	9..118	CDD:293483	64/112 (57%)
		homeodomain	129..180	CDD:238039	36/50 (72%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	168..264		40/122 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.810