DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Optix and Six6

DIOPT Version :9

Sequence 1:	NP_001260793.1	Gene:	Optix / 44108	FlyBaseID:	FBgn0025360	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_001101502.1	Gene:	Six6 / 314221	RGDID:	1310497	Length:	246	Species:	Rattus norvegicus

Alignment Length:	251	Identity:	169/251 - (67%)
Similarity:	192/251 - (76%)	Gaps:	12/251 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILN-CEAVLRARAVVAYHVGNF 95
            :|.|.||..||..||:|||:|||:|||.||||||||| |...|.|| .|:||||||:||:|.||:
  Rat     4 LPILNFSPQQVAGVCETLEESGDVERLGRFLWSLPVA-PAACEALNKNESVLRARAIVAFHGGNY 67

  Fly    96 RELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKT 160
            ||||.|:|||||||.|:.||||:||||||.||||||||.||||||||||||||||.|||||||||
  Rat    68 RELYHILENHKFTKESHAKLQALWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKT 132

  Fly   161 HCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQN 225
            ||||||||.||||||||||||||:||||||:||||.|||||||||||||||||||||||:|....
  Rat   133 HCFKERTRHLLREWYLQDPYPNPSKKRELAQATGLTPTQVGNWFKNRRQRDRAAAAKNRLQQQVL 197

  Fly   226 SSGMGCRSRRADGAASPTPSDSSDSDISLGTHSPVPSSLQLQHSPGSTSNGANDRE 281
            |.|.| |..|::|..:|.         .||..|...:||..:.:..:.|..::|.|
  Rat   198 SQGPG-RVLRSEGEGTPE---------VLGVASSPAASLSSKAATSAISITSSDSE 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:293483	85/113 (75%)
Optix	NP_001260793.1	homeodomain	158..206	CDD:238039	43/47 (91%)
Six6	NP_001101502.1	SIX1_SD	9..122	CDD:407119	85/113 (75%)
Six6	NP_001101502.1	homeodomain	130..178	CDD:238039	43/47 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352060
Domainoid	1	1.000	175	1.000	Domainoid score	I3548
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	321	1.000	Inparanoid score	I2432
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002292
OrthoInspector	1	1.000	-	-		otm45752
orthoMCL	1	0.900	-	-		OOG6_105562
Panther	1	1.100	-	-	LDO	PTHR10390
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X333
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.750