Protein Alignment Optix and Six5

DIOPT Version :9

• Sequence 1: NP_001260793.1
• Gene: Optix / 44108
• FlyBaseID: FBgn0025360
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_001359006.1
• Gene: Six5 / 308406
• RGDID: 1305040
• Length: 720
• Species: Rattus norvegicus
• Alignment Length: 555
• Identity: 183/555 - (32%)
• Similarity: 240/555 - (43%)
• Gaps: 141/555 - (25%)

  Fly     2 AVGPTEG----KQPPSESFSPTHHQIIAPSPILAVPTLAFSAAQVEIVCKTLEDSGDIERLARFL 62
            |.|..||    ...||...||......||:      .|.||..||..||:.|..:|...||:|||
  Rat    45 AAGAGEGAAADSGSPSGPGSPRETGTEAPT------GLRFSPEQVACVCEALLQAGHAGRLSRFL 103

  Fly    63 WSLPVALPNMHEILNCEAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEA 127
            .:||.|    ..:...:.||||||:||:..|.:.|||.::|:..|..|.:..||.::|.|.|.||
  Rat   104 GALPPA----ERLRGSDPVLRARALVAFQRGEYAELYQLLESRPFPAAHHAFLQDLYLRARYHEA 164

  Fly   128 EKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKA 192
            |:.|||:||.|||||:|||||||.||||||:..:|||||:|:.|:..|..:.||.|.:||.||..
  Rat   165 ERARGRALGAVDKYRLRKKFPLPKTIWDGEETVYCFKERSRAALKACYRGNRYPTPDEKRRLATL 229

  Fly   193 TGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNSSGMGCRSRRADGAASPTPSDSSD---SDI-- 252
            |||:.|||.|||||||||||..          ...|..|:| .:||  :||..|.|.   .|:
  Rat   230 TGLSLTQVSNWFKNRRQRDRTG----------TGGGAPCKS-ESDG--NPTTEDESSRSPEDLER 281

  Fly   253 ---SLGTHSPVPSSLQLQHS------PGSTS------------------NGANDREESLSVDDDK 290
               |:...:|..||:.|..:      |.|:|                  ||:.....||::.:..
  Rat   282 GVASVAAEAPTQSSIFLAGATPSATCPASSSILVNGSFLAASSPPAVLLNGSPVIINSLTLGEGS 346

  Fly   291 ---PRDLSGSLPLPLSLPLPL-ASPTHTPPQLPPGYG---------------GGAGAGPGGPLTG 336
               |..|:|....|...|.|. .|.|.|...|.|..|               |..|..||..:
  Rat   347 SLGPLLLTGGGGTPQPQPSPQGVSETKTSLVLDPQTGEVRLDEAQSEAPEAKGVHGTTPGEEI-- 409

  Fly   337 PGCLP---PFKLDAATSLFSAGCYLQSFSNLKEMSQQFPIQPIVLRPHPQLPQSLALNGASG--- 395
            ||.||   |....|:|                     ||:.|..: |....||.:.|:.:||
  Rat   410 PGTLPQVVPGPPPAST---------------------FPLTPGAV-PSVAAPQVVPLSPSSGYPT 452

  Fly   396 -----GPPLHHPAYAAAYSVECVPGGHGPPHPPPKLRI-----NSPEKLNSTAVAAAASVGGGGG 450
                 .|.|:.|.......|..:|...||      |::     .||.|:.:||         |..
  Rat   453 GLSPTSPLLNLPQVVPTSQVVTLPQAVGP------LQLLAAGPGSPVKVAATA---------GPT 502

  Fly   451 NQHHEPTTTGY--------HHSGQLMLHRPFSTSP 477
            |.|...::.|.        ...|.|:|..|.|.||
  Rat   503 NVHLINSSVGVTALQLPSSATPGNLLLANPVSGSP 537

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:293483	54/112 (48%)
		homeodomain	158..206	CDD:238039	24/47 (51%)
Six5	NP_001359006.1	SIX1_SD	78..187	CDD:374862	54/112 (48%)
		homeodomain	198..249	CDD:238039	30/50 (60%)
		PHA03247	<414..652	CDD:223021	37/161 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352063
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840