DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Optix and six3b

DIOPT Version :9

Sequence 1:	NP_001260793.1	Gene:	Optix / 44108	FlyBaseID:	FBgn0025360	Length:	492	Species:	Drosophila melanogaster
Sequence 2:	NP_571438.1	Gene:	six3b / 30636	ZFINID:	ZDB-GENE-990415-128	Length:	293	Species:	Danio rerio

Alignment Length:	289	Identity:	177/289 - (61%)
Similarity:	205/289 - (70%)	Gaps:	20/289 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 PSESFSPTHHQ---IIAPS----------PILAVPTLAFSAAQVEIVCKTLEDSGDIERLARFLW 63
            ||..|.|....   ::|.|          |:..:|||.|||.||..||:|||::||||||.||||
Zfish    11 PSHLFLPNFADRPLLLAGSIPRARSPEDLPMFQLPTLNFSAEQVASVCETLEETGDIERLGRFLW 75

  Fly    64 SLPVALPNMHEILN-CEAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEA 127
            ||||| |...:.:| .|::.|||||||||.|:|||||.|:|.|||||.|:||||||||||||.||
Zfish    76 SLPVA-PGACDAINKHESIQRARAVVAYHTGSFRELYHILETHKFTKDSHGKLQAMWLEAHYQEA 139

  Fly   128 EKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKA 192
            ||||||.||||||||||||||||.|||||||||||||||||.||||||||||||||:||||||:|
Zfish   140 EKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRGLLREWYLQDPYPNPSKKRELAQA 204

  Fly   193 TGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNSSGMGCRSRRADGAASPTPSDSSDSDISLGTH 257
            |||.|||||||||||||||||||||||:||    .|:|..|.|:...:..||..|::|..:..:.
Zfish   205 TGLTPTQVGNWFKNRRQRDRAAAAKNRLQH----HGLGQSSLRSMSESGCTPHSSAESPCAAASP 265

  Fly   258 SPVPSSLQLQHSPGSTSNGANDREESLSV 286
            :...||:. :...|.|.....|.:....|
Zfish   266 TTSVSSMN-ERGDGGTILSVTDSDSDFDV 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:293483	85/113 (75%)
Optix	NP_001260793.1	homeodomain	158..206	CDD:238039	43/47 (91%)
six3b	NP_571438.1	SIX1_SD	49..162	CDD:293483	85/113 (75%)
six3b	NP_571438.1	homeodomain	170..218	CDD:238039	43/47 (91%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593951
Domainoid	1	1.000	175	1.000	Domainoid score	I3584
eggNOG	1	0.900	-	-		E1_KOG0775
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H122422
Inparanoid	1	1.050	334	1.000	Inparanoid score	I2392
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002292
OrthoInspector	1	1.000	-	-		otm24942
orthoMCL	1	0.900	-	-		OOG6_105562
Panther	1	1.100	-	-	O	PTHR10390
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X333
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.750