Protein Alignment Optix and Six3

DIOPT Version :10

• Sequence 1: NP_001260793.1
• Gene: Optix / 44108
• FlyBaseID: FBgn0025360
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: XP_017172856.1
• Gene: Six3 / 20473
• MGIID: 102764
• Length: 354
• Species: Mus musculus
• Alignment Length: 253
• Identity: 175/253 - (69%)
• Similarity: 192/253 - (75%)
• Gaps: 24/253 - (9%)

  Fly     8 GKQPPSESFSPTHHQIIAPSPILAVPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNM 72
            |.:.|.|..|           :..:|||.||..||..||:|||::||||||.||||||||| |..
Mouse    91 GSRAPPEELS-----------MFQLPTLNFSPEQVASVCETLEETGDIERLGRFLWSLPVA-PGA 143

  Fly    73 HEILN-CEAVLRARAVVAYHVGNFRELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLG 136
            .|.:| .|::||||||||:|.||||:||.|:|||||||.|:||||||||||||.||||||||.||
Mouse   144 CEAINKHESILRARAVVAFHTGNFRDLYHILENHKFTKESHGKLQAMWLEAHYQEAEKLRGRPLG 208

  Fly   137 PVDKYRVRKKFPLPPTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVG 201
            ||||||||||||||.||||||||||||||||||||||||||||||||:||||||:||||.|||||
Mouse   209 PVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPSKKRELAQATGLTPTQVG 273

  Fly   202 NWFKNRRQRDRAAAAKNRIQHSQ-NSSGM------GC----RSRRADGAASPTPSDSS 248
            ||||||||||||||||||:||.. ..|||      ||    .:.....|||||.|.||
Mouse   274 NWFKNRRQRDRAAAAKNRLQHQAIGPSGMRSLAEPGCPTHGSAESPSTAASPTTSVSS 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:465293	86/113 (76%)
		homeodomain	158..206	CDD:238039	44/47 (94%)
Six3	XP_017172856.1	SIX1_SD	109..222	CDD:465293	86/113 (76%)
		homeodomain	230..278	CDD:238039	44/47 (94%)