Protein Alignment Optix and Six1

DIOPT Version :10

• Sequence 1: NP_001260793.1
• Gene: Optix / 44108
• FlyBaseID: FBgn0025360
• Length: 492
• Species: Drosophila melanogaster
• Sequence 2: NP_446211.1
• Gene: Six1 / 114634
• RGDID: 620906
• Length: 284
• Species: Rattus norvegicus
• Alignment Length: 282
• Identity: 136/282 - (48%)
• Similarity: 181/282 - (64%)
• Gaps: 27/282 - (9%)

  Fly    32 VPTLAFSAAQVEIVCKTLEDSGDIERLARFLWSLPVALPNMHEILNCEAVLRARAVVAYHVGNFR 96
            :|:..|:..||..||:.|:..|::|||.||||||| |..::|:   .|:||:|:||||:|.||||
  Rat     4 LPSFGFTQEQVACVCEVLQQGGNLERLGRFLWSLP-ACDHLHK---NESVLKAKAVVAFHRGNFR 64

  Fly    97 ELYAIIENHKFTKASYGKLQAMWLEAHYIEAEKLRGRSLGPVDKYRVRKKFPLPPTIWDGEQKTH 161
            |||.|:|:|:|:..::.|||.:||:|||:||||||||.||.|.|||||:|||||.||||||:.::
  Rat    65 ELYKILESHQFSPHNHPKLQQLWLKAHYVEAEKLRGRPLGAVGKYRVRRKFPLPRTIWDGEETSY 129

  Fly   162 CFKERTRSLLREWYLQDPYPNPTKKRELAKATGLNPTQVGNWFKNRRQRDRAAAAKNRIQHSQNS 226
            ||||::|.:|||||..:|||:|.:|||||:||||..|||.|||||||||||||.||.|.....|:
  Rat   130 CFKEKSRGVLREWYAHNPYPSPREKRELAEATGLTTTQVSNWFKNRRQRDRAAEAKERENTENNN 194

  Fly   227 SGMGCRSRRADGAASPTPSDSSDSDISLGTHSPVPSSLQLQHSPGSTSNGANDREESLSVDDDKP 291
            |     |.......||           |....|:.||.:.:.||..:.    |:...|.:..:..
  Rat   195 S-----SSNKQNQLSP-----------LEGGKPLMSSSEEEFSPPQSP----DQNSVLLLQSNMG 239

  Fly   292 RDLSGSLPLPLSLPLPLASPTH 313
            ...|.:..||   .|..:.|:|
  Rat   240 HARSSNYSLP---GLTASQPSH 258

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Optix	NP_001260793.1	SIX1_SD	37..150	CDD:465293	66/112 (59%)
		homeodomain	158..206	CDD:238039	29/47 (62%)
Six1	NP_446211.1	SIX1_SD	9..118	CDD:465293	66/112 (59%)
		homeodomain	129..180	CDD:238039	35/50 (70%)